YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis
Diabetes, 2020 An increasing number of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropathy (DN), and progressive renal tubulointerstitial fibrosis is an important mediator of progressive kidney dysfunction in DN. In this study, we
Jianchun Chen +6 more
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Far infrared radiation promotes rabbit renal proximal tubule cell proliferation and functional characteristics, and protects against cisplatin-induced nephrotoxicity. [PDF]
PLoS ONE, 2017 Far infrared radiation, a subdivision of the electromagnetic spectrum, is beneficial for long-term tissue healing, anti-inflammatory effects, growth promotion, sleep modulation, acceleration of microcirculation, and pain relief.
I-Ni Chiang +3 more
doaj +1 more source
Functional Evaluation and Nephrotoxicity Assessment of Human Renal Proximal Tubule Cells on a Chip
Biosensors, 2022 An in vitro human renal proximal tubule model that represents the proper transporter expression and pronounced epithelial polarization is necessary for the accurate prediction of nephrotoxicity. Here, we constructed a high-throughput human renal proximal
Bolin Jing +5 more
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Transcriptomes of Major Proximal Tubule Cell Culture Models.
Journal of the American Society of Nephrology, 2020 BACKGROUND Cultured cell lines are widely used for research in the physiology, pathophysiology, toxicology, and pharmacology of the renal proximal tubule. The lines that are most appropriate for a given use depend upon the genes expressed.
S. Khundmiri +4 more
semanticscholar +1 more source
Cells, 2022 Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite decades of study. Alterations in the glomerulus and kidney tubules both contribute to the pathogenesis of DKD although the majority of investigative efforts have ...
Kimberly S. Collins +14 more
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Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]
, 2017 We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
core +1 more source
Evaluation of transporter expression in HK-2 cells after exposure to free and ester-bound 3-MCPD
Toxicology Reports, 2021 3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in some infant formula products and other foods in the United States. Although rodent studies have demonstrated that 3-MCPD and its palmitic esters have the potential to induce ...
Miriam E. Mossoba +4 more
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Pacsin2 is required for endocytosis in the zebrafish pronephric tubule
Biology Open, 2022 Endocytosis mediates the cellular uptake of numerous molecules from the extracellular space and is a fundamentally important process. In the renal proximal tubule, the scavenger receptor megalin and its co-receptor cubilin mediate endocytosis of low ...
Joseph Morgan +4 more
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The Fanconi syndrome of cystinosis: insights into the pathophysiology
The Turkish Journal of Pediatrics, 2002 Cystinosis is a lysosomal storage disease, and is one of the most common causes of the Fanconi syndrome. In vitro studies of the cystine-loaded tubule provided insights into the pathophysiology of the proximal tubular defect.
Abdullah Sakarcan
doaj +1 more source
Renal reabsorption in 3D vascularized proximal tubule models
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Current kidney-on-chip models lack the 3D geometry, complexity, and functionality vital for recapitulating in vivo renal tissue. We report the fabrication and perfusion of 3D vascularized proximal tubules embedded within an engineered ECM ...
N. Y. Lin +6 more
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