Results 21 to 30 of about 53,901 (263)
A modular and reusable model of epithelial transport in the proximal convoluted tubule.
PLoS ONE, 2022 We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature.
Leyla Noroozbabaee +3 more
doaj +1 more source
Ontogeny of proximal tubule acidification
Kidney International, 1995 The proximal tubule is responsible for the reabsorption of 80% of the filtered load of bicarbonate in adults. Proximal tubule bicarbonate reabsorption is affected by a number of hormones, acid-base balance, and the extracellular fluid volume status [1]. The adult proximal tubule thus plays a central role in acid-base homeostasis.
Baum, Michel, Quigley, Raymond
openaire +2 more sources
PLoS ONE, 2021 The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand ...
Natalya A Blessing +9 more
doaj +1 more source
Scientific Reports, 2017 Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes.
Soomin Chae +19 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 The kidney proximal tubule is responsible for reabsorbing water and NaCl to maintain the homeostasis of the body fluids, electrolytes, and nutrients.
Min Heui Yoo +6 more
doaj +1 more source
The Proximal Tubule in Cystinosis [PDF]
Journal of the American Society of Nephrology, 2014 Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as ...
openaire +2 more sources
Proximal renal tubular acidosis with and without Fanconi syndrome
Kidney Research and Clinical Practice, 2019 Proximal renal tubular acidosis (RTA) is caused by a defect in bicarbonate (HCO3−) reabsorption in the kidney proximal convoluted tubule. It usually manifests as normal anion-gap metabolic acidosis due to HCO3− wastage.
Ibrahim Kashoor, Daniel Batlle
doaj +1 more source
Design Engineering of a Bioartificial Renal Tubule Cell Therapy Device
Cell Transplantation, 1999 The use of a bioartificial renal tubule device composed of renal proximal tubule cells grown within a hollow fiber cartridge is a first step in engineering a bioartificial kidney to provide more complete replacement therapy of renal function than is ...
Janeta Nikolovski +2 more
doaj +1 more source
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. [PDF]
PLoS ONE, 2012 Ischemia/reperfusion (I/R) is at the basis of renal transplantation and acute kidney injury. Molecular mechanisms underlying proximal tubule response to I/R will allow the identification of new therapeutic targets for both clinical settings.
Elia Aguado-Fraile +9 more
doaj +1 more source
Receptor-Mediated Endocytosis in the Proximal Tubule [PDF]
Annual Review of Physiology, 2017 Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease ...
Megan L, Eshbach, Ora A, Weisz
openaire +2 more sources