Results 11 to 20 of about 684,958 (347)

3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake

Scientific Reports, 2022
Three-dimensional, organ-on-chip models that recapitulate kidney tissue are needed for drug screening and disease modeling. Here, we report a method for creating a perfusable 3D proximal tubule model composed of epithelial cells isolated from kidney ...
Jeffrey O. Aceves, Szilvia Heja, Kenichi Kobayashi, Sanlin S. Robinson, Tomoya Miyoshi, Takuya Matsumoto, Olivier J. M. Schäffers, Ryuji Morizane, Jennifer A. Lewis   +8 more
doaj   +2 more sources

The Proximal Tubule and Albuminuria [PDF]

Journal of the American Society of Nephrology, 2014
Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and approaches have provided exciting insights into these processes, and numerous investigators have shown that selective PT cell defects lead to significant albuminuria, even ...
Dickson, Landon E., Wagner, Mark C., Sandoval, Ruben M., Molitoris, Bruce A.   +3 more
openaire   +3 more sources

Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. [PDF]

PLoS ONE, 2016
Exosomes are nanometer-scale, cell-derived vesicles that contain various molecules including nucleic acids, proteins, and lipids. These vesicles can release their cargo into adjacent or distant cells and mediate intercellular communication and cellular ...
Kishore Kumar Jella, Ling Yu, Qiang Yue, Daniel Friedman, Billie J Duke, Abdel A Alli   +5 more
doaj   +2 more sources

Receptor-Mediated Endocytosis in the Proximal Tubule [PDF]

Annual Review of Physiology, 2017
Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease ...
Megan L, Eshbach, Ora A, Weisz
openaire   +3 more sources

Renal fibrosis: Primacy of the proximal tubule [PDF]

Matrix Biology, 2018
Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of renal survival. Many different cell types contribute to TIF progression including tubular epithelial cells, myofibroblasts, endothelia, and inflammatory cells.
L. Gewin
openaire   +3 more sources

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance A single acute kidney injury event increases the risk of progression to chronic kidney disease (CKD). Combining single-nucleus RNA sequencing with genetic tracing of injured proximal tubule cells identified a spatially dynamic, evolving ...
Louisa M. S. Gerhardt, Jing Liu, Kari Koppitch, Pietro E. Cippà, A. McMahon   +4 more
semanticscholar   +1 more source

Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications

Physiological Reviews, 2022
For nearly fifty years the proximal tubule has been known to reabsorb, process, and either catabolize or transcytose albumin from the glomerular filtrate.
B. Molitoris, R. Sandoval, S. Yadav, M. Wagner   +3 more
semanticscholar   +1 more source

Cells sorted off hiPSC-derived kidney organoids coupled with immortalized cells reliably model the proximal tubule

Communications Biology, 2023
Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption.
Ramin Banan Sadeghian, Ryohei Ueno, Yuji Takata, Akihiko Kawakami, Cheng Ma, Toshikazu Araoka, Minoru Takasato, Ryuji Yokokawa   +7 more
doaj   +1 more source

Modelling Renal Filtration and Reabsorption Processes in a Human Glomerulus and Proximal Tubule Microphysiological System

Micromachines, 2021
Kidney microphysiological systems (MPS) serve as potentially valuable preclinical instruments in probing mechanisms of renal clearance and osmoregulation. Current kidney MPS models target regions of the nephron, such as the glomerulus and proximal tubule
Stephanie Y. Zhang, Gretchen J. Mahler
doaj   +1 more source

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Kidney International, 2020
Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells.
A. Werion, L. Belkhir, Marie Perrot, G. Schmit, S. Aydın, Zhiyong Chen, A. Penaloza, J. de Greef, H. Yildiz, L. Pothen, J. Yombi, J. Dewulf, A. Scohy, L. Gérard, X. Wittebole, P. Laterre, S. Miller, O. Devuyst, M. Jadoul, J. Morelle, Frank Souad Nadia Sarah Christophe Diego Emmanuel Christ Aboubakar Acid Amini Bailly Beauloye Castanares-Za, F. Aboubakar, S. Acid, N. Amini, S. Bailly, C. Beauloye, D. Castanares-Zapatero, E. Coche, C. Collienne, P. Cornette, Isabelle De Brauwer, M. Dechamps, F. Dupriez, A. Froidure, Q. Garnir, B. Gerber, B. Ghaye, I. Gilard, S. Gohy, C. Grégoire, P. Hantson, L. Jacquet, B. Kabamba, S. Kautbally, N. Lanthier, Fatima Larbaoui, G. Liistro, F. Maes, V. Montiel, B. Mwenge, S. Pierard, C. Pilette, A. Pouleur, Amaury Sogorb, P. Starkel, H. Rodriguez‐Villalobos, M. Thoma, Olivier Van Caeneghem, D. Vancraeynest   +58 more
semanticscholar   +1 more source