Results 41 to 50 of about 611,505 (395)
Ecotoxicology and Environmental Safety, 2022 The kidney proximal tubule is responsible for reabsorbing water and NaCl to maintain the homeostasis of the body fluids, electrolytes, and nutrients.
Min Heui Yoo +6 more
doaj +1 more source
Quantitative morphology of renal cortical structures during compensatory hypertrophy [PDF]
, 1998 The compensatory hypertrophy in different renal cortical structures was studied in rats 10 and 21 days after unilateral nephrectomy (UNX). Quantitative morphological/stereological analysis revealed significant increases in total renal cortical volume ...
Beck, Franz-X. +4 more
core +1 more source
Proximal renal tubular acidosis with and without Fanconi syndrome
Kidney Research and Clinical Practice, 2019 Proximal renal tubular acidosis (RTA) is caused by a defect in bicarbonate (HCO3−) reabsorption in the kidney proximal convoluted tubule. It usually manifests as normal anion-gap metabolic acidosis due to HCO3− wastage.
Ibrahim Kashoor, Daniel Batlle
doaj +1 more source
AJP - Renal Physiology, 2018 The goal of this study is to investigate the functional implications of the sexual dimorphism in transporter patterns along the proximal tubule. To do so, we have developed sex-specific computational models of solute and water transport in the proximal ...
Qianyi Li +3 more
semanticscholar +1 more source
Design Engineering of a Bioartificial Renal Tubule Cell Therapy Device
Cell Transplantation, 1999 The use of a bioartificial renal tubule device composed of renal proximal tubule cells grown within a hollow fiber cartridge is a first step in engineering a bioartificial kidney to provide more complete replacement therapy of renal function than is ...
Janeta Nikolovski +2 more
doaj +1 more source
Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]
, 2018 We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie +2 more
core +1 more source
Potential and Limits of Kidney Cells for Evaluation of Renal Excretion
Pharmaceuticals, 2021 A large number of therapeutic drugs, herbal components and their metabolites are excreted by the kidneys. Therefore, generally applied models for estimating renal excretion, including freshly isolated rat proximal tubule cells, cultured tubule cells and ...
Christian Lechner +3 more
doaj +1 more source
Frontiers in Physiology, 2017 Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a primary site of nephrotoxicity and resulting attrition in the drug development pipeline.
M. Gumz +16 more
semanticscholar +1 more source
Changes in renal WT-1 expression preceding hypertension development [PDF]
, 2016 Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica +8 more
core +2 more sources
A microfluidic renal proximal tubule with active reabsorptive function
PLoS ONE, 2017 In the kidney, the renal proximal tubule (PT) reabsorbs solutes into the peritubular capillaries through active transport. Here, we replicate this reabsorptive function in vitro by engineering a microfluidic PT. The microfluidic PT architecture comprises
E. Vedula +3 more
semanticscholar +1 more source