Results 41 to 50 of about 605,238 (303)
Geometrically programmed self-limited assembly of tubules using DNA origami colloids [PDF]
PNAS 119 (43) e2207902119 (2022), 2022 Self-assembly is one of the most promising strategies for making functional materials at the nanoscale, yet new design principles for making self-limiting architectures, rather than spatially unlimited periodic lattice structures, are needed. To address this challenge, we explore the trade-offs between addressable assembly and self-closing assembly of ...
arxiv +1 more source
Renal reabsorption in 3D vascularized proximal tubule models
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Current kidney-on-chip models lack the 3D geometry, complexity, and functionality vital for recapitulating in vivo renal tissue. We report the fabrication and perfusion of 3D vascularized proximal tubules embedded within an engineered ECM ...
N. Y. Lin +6 more
semanticscholar +1 more source
Membrane tubule formation by banana-shaped proteins with or without transient network structure [PDF]
Sci. Rep. 6, 20935 (2016), 2015 In living cells, membrane morphology is regulated by various proteins. Many membrane reshaping proteins contain a Bin/Amphiphysin/Rvs (BAR) domain, which consists of a banana-shaped rod. The BAR domain bends the biomembrane along the rod axis and the features of this anisotropic bending have recently been studied. Here, we report on the role of the BAR
arxiv +1 more source
Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.
AJP - Renal Physiology, 2018 Ferroptosis is an iron-dependent form of regulated nonapoptotic cell death, which contributes to damage in models of acute kidney injury (AKI). Heme oxygenase-1 (HO-1) is a cytoprotective enzyme induced in response to cellular stress, and is protective ...
Oreoluwa O. Adedoyin +6 more
semanticscholar +1 more source
PLoS ONE, 2021 The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand ...
Natalya A Blessing +9 more
doaj +1 more source
Scientific Reports, 2017 Peroxiredoxin1 (Prdx1) is an antioxidant enzyme belonging to the peroxiredoxin family of proteins. Prdx1 catalyzes the reduction of H2O2 and alkyl hydroperoxide and plays an important role in different biological processes.
Soomin Chae +19 more
doaj +1 more source
Dimerization structures on the metallic and semiconducting fullerene tubules [PDF]
Phys.Rev. B47 (1993) 16563-16569, 1992 The Kekule patterns are realized in the metallic tubules and chain-like distortions occur in the semiconducting tubules.
arxiv +1 more source
FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury.
Journal of Clinical Investigation, 2019 The proximal tubule has a remarkable capacity for repair after acute injury, but the cellular lineage and molecular mechanisms underlying this repair response are incompletely understood. Here, we developed a Kim1-GFPCreERt2 knockin mouse line (Kim1-GCE)
Monica Chang-Panesso +9 more
semanticscholar +1 more source
Phases and Transitions in Phantom Nematic Elastomer Membranes [PDF]
Phys. Rev. E 71, 011802 (2005), 2004 Motivated by recently discovered unusual properties of bulk nematic elastomers, we study a phase diagram of liquid-crystalline polymerized phantom membranes, focusing on in-plane nematic order. We predict that such membranes should enerically exhibit five phases, distinguished by their conformational and in-plane orientational properties, namely ...
arxiv +1 more source
Journal of the American Society of Nephrology, 2019 BACKGROUND Proximal tubule injury can initiate CKD, with progression rates that are approximately 50% faster in males versus females. The precise transcriptional changes in this nephron segment during fibrosis and potential differences between sexes ...
Haojia Wu +3 more
semanticscholar +1 more source