Results 41 to 50 of about 93,932 (331)

Quantitative morphology of renal cortical structures during compensatory hypertrophy [PDF]

, 1998
The compensatory hypertrophy in different renal cortical structures was studied in rats 10 and 21 days after unilateral nephrectomy (UNX). Quantitative morphological/stereological analysis revealed significant increases in total renal cortical volume ...
Beck, Franz-X., Giebisch, Gerhard, Ohno, Akihiro, Pfaller, Walter, Seppi, Thomas   +4 more
core   +1 more source

BMP-7 and the proximal tubule [PDF]

Kidney International, 2002
Bone morphogenetic protein-7 (BMP-7), also known as ostegenic protein-1, is a member of the transforming growth factor- (TGF-) superfamily that is expressed widely in embryonic life and plays a critical role in renal development (reviewed in1). BMP-7 is expressed particularly by the ureteric bud and also by the nephrogenic mesenchyme and the collecting
openaire   +2 more sources

Determinants of the effect of furosemide on the proximal tubule

Kidney International, 1972
Determinants of the effect of furosemide on the proximal tubule.The recollection renal micropuncture technique was used to assess fractional and, on occasion, absolute volume reabsorption in the dog late proximal tubule before and during a furosemide diuresis in which urine losses were or were not replaced.Similar observations were made before and ...
James R. Clapp, Thomas J. Burke, Roscoe R. Robinson   +2 more
openaire   +3 more sources

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and ...
Arriza, Benediktsson, Berl, Brown, Brown, Chomczynski, Christopher Kenyon, Christopher R.W. Edwards, Clark, Cole, Edwards, Fleming, Gordon, Grone, Grunder, Guyton, Jamieson, John J. Mullins, Jonathan R. Seckl, Kaissling, Kotelevtsev, Krozowski, Lifton, Lindsay, Low, Millar, Mune, Nehls, Roger W. Brown, Sharp, Shimkets, Simon, Stewart, Stewart, Stewart, Stewart Fleming, Ulick, White, White, Yuri Kotelevtsev   +39 more
core   +3 more sources

The Proximal Tubule in Cystinosis [PDF]

Journal of the American Society of Nephrology, 2014
Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as ...
openaire   +2 more sources

Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection

Chinese Medical Journal, 2021
. Background:. Since 2019, a novel coronavirus named 2019 novel coronavirus (2019-nCoV) has emerged worldwide. Apart from fever and respiratory complications, acute kidney injury has been observed in a few patients with coronavirus disease 2019 ...
Wei Lin, Jue Fan, Long-Fei Hu, Yan Zhang, Joshua D. Ooi, Ting Meng, Peng Jin, Xiang Ding, Long-Kai Peng, Lei Song, Rong Tang, Zhou Xiao, Xiang Ao, Xiang-Cheng Xiao, Qiao-Ling Zhou, Ping Xiao, Yong Zhong, Peng Lyu.   +17 more
doaj   +1 more source

The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure [PDF]

, 2017
Hypertension (HTN), a major public health issue is currently the leading factor in the global burden of disease, where associated complications account for 9.4 million deaths worldwide every year (98).
Dominiczak, Anna, Ferreri, Nicholas R., Graham, Lesley A.   +2 more
core   +1 more source

Solvent drag measurement of transcellular and basolateral membrane NaCl reflection coefficient in kidney proximal tubule. [PDF]

, 1991
The NaCl reflection coefficient in proximal tubule has important implications for the mechanisms of near isosmotic volume reabsorption. A new fluorescence method was developed and applied to measure the transepithelial (sigma NaClTE) and basolateral ...
Fushimi, K, Shi, LB, Verkman, AS
core  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source