Grouper tshβ promoter-driven transgenic zebrafish marks proximal kidney tubule development. [PDF]
PLoS ONE, 2014 Kidney tubule plays a critical role in recovering or secreting solutes, but the detailed morphogenesis remains unclear. Our previous studies have found that grouper tshβ (gtshβ) is also expressed in kidney, however, the distribution significance is still
Yang Wang +4 more
doaj +1 more source
Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship [PDF]
, 2018 Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.
Agüero, Rocio +4 more
core
Effects of antibodies against dynein and tubulin on the stiffness of flagellar axonemes [PDF]
, 1981 Antidynein antibodies, previously shown to inhibit flagellar oscillation and active sliding of axonemal microtubules, increase the bending resistance of axonemes measured under relaxing conditions, but not the bending resistance of axonemes measured ...
Asai, D. J. +3 more
core +1 more source
Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling
Advanced Science, EarlyView.ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li +12 more
wiley +1 more source
A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1. [PDF]
PLoS ONE, 2013 Autosomal dominant polycystic kidney disease (ADPKD) is associated with a variety of cellular phenotypes in renal epithelial cells. Cystic epithelia are secretory as opposed to absorptive, have higher proliferation rates in cell culture and have some ...
Brittney-Shea Herbert +13 more
doaj +1 more source
Continuous growth of proximal tubular kidney epithelial cells in hormone-supplemented serum-free medium. [PDF]
, 1982 An epithelial cell line from pig kidney (LLC-PK1) with properties of proximal tubular cells can be maintained indefinitely in hormone-supplemented serum-free medium. Continuous growth requires the presence of seven factors: transferrin, insulin, selenium,
Chuman, L +3 more
core
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
Journal of Diabetes InvestigationAims/Introduction While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%.
Ellen Wu +14 more
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Inhalation of mercury vapor can cause the toxic effects on rat kidney [PDF]
, 2016 Dental amalgam has been used in dentistry as a filling material. The filler comprises mercury (Hg). It is considered one of the most important and widespread environmental pollutants, which poses a serious potential threat for the humans and animals ...
Akgul, Hayati Murat +5 more
core +1 more source
The Proximal Tubule in Cystinosis [PDF]
Journal of the American Society of Nephrology, 2014 Although rare, nephropathic cystinosis is a devastating monogenic disorder leading to renal failure in the second decade of life. Fanconi syndrome, the initial renal manifestation of cystinosis in the young child, established the proximal tubule as a primary target of injury now recognized as ...
openaire +2 more sources