Results 81 to 90 of about 93,932 (331)

Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics

Nature Communications, 2023
Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown.
Hiroaki Kikuchi, Chung-Lin Chou, Chin-Rang Yang, Lihe Chen, Hyun Jun Jung, Euijung Park, Kavee Limbutara, Benjamin Carter, Zhi-Hong Yang, Julia F. Kun, Alan T. Remaley, Mark A. Knepper   +11 more
doaj   +1 more source

Receptor-Mediated Endocytosis in the Proximal Tubule [PDF]

Annual Review of Physiology, 2017
Cells lining the proximal tubule (PT) of the kidney are highly specialized for apical endocytosis of filtered proteins and small bioactive molecules from the glomerular ultrafiltrate to maintain essentially protein-free urine. Compromise of this pathway results in low molecular weight (LMW) proteinuria that can progress to end-stage kidney disease ...
Ora A. Weisz, Megan L. Eshbach
openaire   +3 more sources

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source

Bisphenol A impairs renal function by reducing Na+/K+-ATPase and F-actin expression, kidney tubule formation in vitro and in vivo

Ecotoxicology and Environmental Safety, 2022
The kidney proximal tubule is responsible for reabsorbing water and NaCl to maintain the homeostasis of the body fluids, electrolytes, and nutrients.
Min Heui Yoo, Seung-Jin Lee, Woojin Kim, Younhee Kim, Yong-Bum Kim, Kyoung–Sik Moon, Byoung-Seok Lee   +6 more
doaj  

Changes in renal WT-1 expression preceding hypertension development [PDF]

, 2016
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica, Calvo, Juan Pablo, Casarotto, Mariana, Cuello Carrión, Fernando Darío, Ferder, León, Fornes, Miguel Walter, García, Isabel Mercedes, Manucha, Walter Ariel Fernando, Mazzei, Luciana Jorgelina   +8 more
core   +2 more sources

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We have previously shown that ATRAP (angiotensin II receptor–associated protein; Agtrap) interacts with AT1R (angiotensin II type 1 receptor) and promotes constitutive internalization of AT1R so as to inhibit hyperactivation of its downstream ...
Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Tomoyuki Koguchi, Kohji Ohki, Kazushi Uneda, Miyuki Matsuda, Sona Haku, Takahiro Yamaji, Takayuki Yamada, Ryu Kobayashi, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Tetsuya Fujikawa, Kouichi Tamura   +16 more
doaj   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]

, 2012
Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed, Manju Sharma, Pankaj S Yadav, Vikas Kumar   +3 more
core   +2 more sources

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source