Results 51 to 60 of about 54,422 (163)

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. [PDF]

Nat Commun, 2023
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J.   +13 more
europepmc   +1 more source

The proximal tubule in the pathophysiology of the diabetic kidney

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
Diabetic nephropathy is a leading cause of end-stage renal disease. A better understanding of the molecular mechanism involved in the early changes of the diabetic kidney may permit the development of new strategies to prevent diabetic nephropathy. This review focuses on the proximal tubule in the early diabetic kidney, particularly on its exposure and
openaire   +3 more sources

Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice

Scientific Reports
Chronic kidney disease (CKD) frequently accompanies hypertension, exacerbating CKD progression in a vicious cycle. Angiotensin II type 1 receptor-associated protein (ATRAP) promotes AT1 receptor internalization to inhibit hyperactivation of its ...
Naohito Okami, Hiromichi Wakui, Shohei Tanaka, Ryu Kobayashi, Shunichiro Tsukamoto, Shinya Taguchi, Ryutaro Morita, Eisuke Kubo, Akio Yamashita, Kengo Azushima, Kouichi Tamura   +10 more
doaj   +1 more source

Clusterin marks maladaptive regenerative responses throughout the kidney following ischemia-reperfusion injury

iScience
Summary: Our understanding of the regenerative capacity of renal tubules has primarily come from studies focusing on proximal tubules. To gain a broader view of injury responses throughout the tubular network, we employed single-cell RNA sequencing ...
Agnieszka Masztalerz, Loïck Joumier, Sunny Zhen, Tomoko Takano, Serge Lemay, Mohan Malleshaiah, Alex Gregorieff   +6 more
doaj   +1 more source

Endocytosis in the proximal tubule [PDF]

Nature Reviews Nephrology, 2018
openaire   +2 more sources

Pengaruh Pemberian Valsartan Dan Kurkumin Terhadap Pembentukan Fibrosis Di Tubulus Proksimal Ginjal Akibat Obstruksi Ureter Unilateral pada Tikus Wistar.

Jurnal Kesehatan Andalas, 2013
AbstrakPendahuluan: Obstruksi ureter adalah kondisi terhalangnya aliran urin dari ginjal ke buli-buli, adanya obstruksi pada ureter memperlambat laju filtrasi glomerulus dan dapat menyebabkan kerusakan parenkim ginjal. Fibrosis pada ginjal yang obstruksi
Lubis M, Alvarino Alvarino, Tofrizal Tofrizal, Erkadius Erkadius   +3 more
doaj  

High-Glucose-Induced Injury to Proximal Tubules of the Renal System Is Alleviated by Netrin-1 Suppression of Akt/mTOR. [PDF]

J Diabetes Res, 2023
Liu C, Hu X, Zhao Y, Huang A, Chen J, Lu T, Wu M, Lu H.   +7 more
europepmc   +1 more source

Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells

BMC Nephrology
Background Diabetes treatments by the control of sodium-glucose cotransporter 2 (SGLT2) is commonly conducted while there are still uncertainties about the mechanisms for the SGLT2 overexpression in kidneys with diabetes.
Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa   +5 more
doaj   +1 more source

Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice. [PDF]

Front Cardiovasc Med, 2023
Kukida M, Amioka N, Ye D, Chen H, Moorleghen JJ, Liang CL, Howatt DA, Katsumata Y, Yanagita M, Sawada H, Daugherty A, Lu HS.   +11 more
europepmc   +1 more source

Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease. [PDF]

BMC Nephrol, 2023
Shi W, Le W, Tang Q, Shi S, Shi J.
europepmc   +1 more source