Results 41 to 50 of about 159,804 (339)

Genetic PrP Prion Diseases [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
Genetic prion diseases (gPrDs) caused by mutations in the prion protein gene (PRNP) have been classified as genetic Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, or fatal familial insomnia. Mutations in PRNP can be missense, nonsense, and/or octapeptide repeat insertions or, possibly, deletions.
Kim, Mee-Ohk, Takada, Leonel T, Wong, Katherine, Forner, Sven A, Geschwind, Michael D   +4 more
openaire   +4 more sources

Terapias alternativas en condromalacia patelar: estudio comparativo entre la terapia con plasma rico en plaquetas (prp), endoret y acido hialuronico, abril 2022 a octubre 2022

Revista Científica CMDLT, 2022
Introducción: el presente trabajo tuvo como objetivo de comparar y analizar la eficacia de las terapias alternativas en condromalacia patelar (terapia con plasma rico en plaquetas, endoret y ácido hialurónico) y determinar si tendremos un tratamiento ...
Jonathan Vásquez Castellano, Eduardo Bustillo Albores   +1 more
doaj   +2 more sources

Consideration of health inequity in systematic reviews and primary studies on risk factors for hearing loss

Cochrane Evidence Synthesis and Methods
Background Health inequities are systematic, avoidable, and unfair differences in health between populations or population subgroups. There is increased recognition of the need for systematic reviews (SRs) to address health inequities, including drawing ...
Simon Briscoe, Elizabeth Shaw, Michael Nunns, Hassanat Lawal, Noreen Orr, Jo Thompson Coon, Ruth Garside, G. J. Melendez‐Torres   +7 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Concentrations of growth factors in platelet-rich plasma and platelet-rich fibrin in a rabbit model

Veterinární Medicína, 2016
Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates which have been used to improve healing and regeneration of damaged tissues.
J. Vokurka, E. Gopfert, M. Blahutkova, E. Buchalova, M. Faldyna   +4 more
doaj   +1 more source

Effects of local administration of platelet-rich plasma and guided tissue regeneration on bone healing in early inserted dental implants - a histomorphometric analysis [PDF]

Veterinarski Glasnik, 2020
Introduction. In order to provide the most favorable conditions for bone healing following implant loading, new techniques such as the use of growth factors to directly or indirectly regulate cell and tissue growth are becoming increasingly popular ...
Duka Miloš, Lazić Zoran, Bubalo Marija, Mihailović Branko, Miladinović Milan, Gvozdić Dragan   +5 more
doaj   +1 more source

Differentiation of ruminant transmissible spongiform encephalopathy isolate types, including bovine spongiform encephalopathy and CH1641 scrapie [PDF]

, 2010
With increased awareness of the diversity of transmissible spongiform encephalopathy (TSE) strains in the ruminant population, comes an appreciation of the need for improved methods of differential diagnosis. Exposure to bovine spongiform encephalopathy (
Bossers, A., Jacobs, J.G., Keulen, L.J.M., van, Langeveld, J.P.M., Sauer, M., Tang, Y.   +5 more
core   +2 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Primary care clinicians’ perspectives on interacting with patients with gynaecological conditions: a systematic review

BJGP Open
Background: Studies have found that women with gynaecological conditions and symptoms do not feel listened to by primary care clinicians (PCCs). Less understood is whether PCCs perceive that there are challenges around listening to and interacting with ...
Simon Briscoe, Jo Thompson Coon, G J Melendez-Torres, Rebecca Abbott, Liz Shaw, Michael Nunns, Ruth Garside   +6 more
doaj   +1 more source