Results 21 to 30 of about 83,022 (311)

Proteinase K-Resistant Material in ARR/VRQ Sheep Brain Affected with Classical Scrapie Is Composed Mainly of VRQ Prion Protein [PDF]

, 2011
Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions.
Bossers, A., A. Bossers, T. Sklaviadis, I. Lantier, F. Lantier, L. J. M. van Keulen, Van Keulen, L., S. McCutcheon, Berthon, P., Lantier, Isabelle, van Keulen, L.J.M., van Zijderveld, F.G., P. Berthon, Lantier, Frédéric, F., Zijderveld, F.G., van, Jacobs, J.G., Keulen, L., Van, Langeveld, J.P.M., Lantier, I., H. Rezaei, J. P. M. Langeveld, Rezaei, Human, Sklaviadis, T., Berthon, Patricia, J. G. Jacobs, F. G. van Zijderveld, Lantier, F., McCutcheon, S., Rezaei, H.   +28 more
core   +1 more source

Gamma Low-Dose-Rate Ionizing Radiation Stimulates Adaptive Functional and Molecular Response in Human Aortic Endothelial Cells in a Threshold-, Dose-, and Dose Rate–Dependent Manner

Dose-Response, 2018
A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease.
Juliana Vieira Dias, Celine Gloaguen, Dimitri Kereselidze, Line Manens, Karine Tack, Teni G Ebrahimian   +5 more
doaj   +1 more source

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy [PDF]

, 1999
A mutation equivalent to P102L in the human PrP gene, associated with Gerstmann-Straussler syndrome (GSS), has been introduced into the murine PrP gene by gene targeting.
Ironside, James, Bostock, C, Somerville, Robert, Tuzi, N L, Baybutt, H, Hope, James, Manson, J C, McConnell, Irene, Baybutt, Herbert, Somerville, R, Ironside, J, Sy, M S, Jamieson, E, Tuzi, Nadia L., Melton, David W., McConnell, I, Will, R, Manson, Jean C., Sy, Man Sun, Melton, D W, Bostock, Christopher, Will, Robert, Sy, Man-Sun, Barron, Rona, Barron, R, Hope, J, Jamieson, Elizabeth   +26 more
core   +1 more source

Bowel Radiation Injury: Complexity of the Pathophysiology and Promises of Cell and Tissue Engineering

Cell Transplantation, 2016
Ionizing radiation is effective to treat malignant pelvic cancers, but the toxicity to surrounding healthy tissue remains a substantial limitation. Early and late side effects not only limit the escalation of the radiation dose to the tumor but may also ...
Lara Moussa, Benoît Usunier, Christelle Demarquay, Marc Benderitter, Radia Tamarat, Alexandra Sémont, Noëlle Mathieu   +6 more
doaj   +1 more source

PrP knock-out and PrP transgenic mice in prion research [PDF]

British Medical Bulletin, 2003
Spongiform encephalopathies such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD) and Gerstmann-Sträussler-Scheinker syndrome (GSS) in humans is caused by a transmissible agent designated prion. The 'protein only' hypothesis proposes that the prion consists partly or entirely of a conformational ...
C, Weissmann, E, Flechsig
openaire   +2 more sources

Intra- and interspecies interactions between prion proteins and effects of mutations and polymorphisms [PDF]

, 2003
Recently, crystallization of the prion protein in a dimeric form was reported. Here we show that native soluble homogenous FLAG-tagged prion proteins from hamster, man and cattle expressed in the baculovirus system are predominantly dimeric.
Hundt, C., Weiss, S., Riley, M. L., Gauczynski, S., Leucht, C.   +4 more
core   +1 more source

Platelet Rich Plasma Therapy in the Osteoarthritis of The Knee: A Novel Protocol to Enhance Efficacy

Journal of Bone and Joint Diseases, 2021
Introduction: Osteoarthritis (OA), with prevalence as high as 17 to 60.6%, is estimated to be the fourth leading cause of disability. There has been an increase in prevalence of knee osteoarthritis by as much as 100% since the mid-20th century. Materials
A Agarwal, V.K Agarwal, R Mehta, R Narula   +3 more
doaj   +1 more source

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway [PDF]

Journal of Virology, 2015
ABSTRACT Prion diseases are characterized by conformational changes of a cellular prion protein (PrP C ) into a β-sheet-enriched and aggregated conformer (PrP Sc ). Shadoo (Sho), a member of the prion protein family, is expressed in the central nervous system (CNS) and is highly ...
Ciric, Danica, Richard, Charles-Adrien, Moudjou, Mohammed, Chapuis, Jérôme, Sibille, Pierre, Daude, Nathalie, Westaway, David, Adrover, Miguel, Béringue, Vincent, Martin, Davy, Rezaei, Human   +10 more
openaire   +3 more sources

Prion protein self-peptides modulate prion interactions and conversion [PDF]

, 2009
Background: Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrPC) into the scrapie associated isoform (PrPSc), are poorly understood.
Bossers, A., Fred G van Zijderveld, Priem, J., Drophatie Timmers-Parohi, Rigter, A., Alex Bossers, Alan Rigter, Timmers-Parohi, D., Jan PM Langeveld, van Zijderveld, F.G., Zijderveld, F.G., van, Jan Priem, Langeveld, J.P.M.   +12 more
core   +1 more source

Management of Fibrosis: The Mesenchymal Stromal Cells Breakthrough

Stem Cells International, 2014
Fibrosis is the endpoint of many chronic inflammatory diseases and is defined by an abnormal accumulation of extracellular matrix components. Despite its slow progression, it leads to organ malfunction. Fibrosis can affect almost any tissue.
Benoît Usunier, Marc Benderitter, Radia Tamarat, Alain Chapel   +3 more
doaj   +1 more source