Results 61 to 70 of about 159,804 (339)

Comparison of steroid and platelet-rich plasma (prp) applications in the treatment of collagenase induced tendinopathy in rabbit [PDF]

Eurasian Journal of Veterinary Sciences, 2021
Aim: The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I) Materials ...
Nuriza Zamirbekova, Nuri Yavru
doaj  

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrPres [PDF]

, 2006
Prion diseases are associated with the conversion of the normal cellular prion protein, PrPc, to the abnormal, disease-associated form, PrPSc. This conversion can be mimicked in vitro by using a cell-free conversion assay. It has recently been shown that
Gill, Andrew C., Goldmann, Wilfred, Houston, Fiona, Kirby, Louise, Manson, Jean C.   +4 more
core   +1 more source

PrP-C and PrP-Sc at the Fetal-Maternal Interface [PDF]

Journal of Biological Chemistry, 2001
Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes.
Tuo, Wenbin, Zhuang, Dongyue, Knowles, Donald P., Cheevers, William P., Sy, Man-Sun, O'Rourke, Katherine I.   +5 more
openaire   +3 more sources

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

PrP Conformational Transitions Alter Species Preference of a PrP-specific Antibody [PDF]

Journal of Biological Chemistry, 2010
The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to human PrP-(109-112). This assumption is based mainly on the observation that 3F4 reacts with human and hamster PrP but not with PrP from mouse, sheep, and cervids, in which Met at residue 112 is ...
Zou, W.Q., Langeveld, J.P.M., Xiao, X., Chen, S., McGeer, P.L., Yuan, J., Payne, M.C., Kang, H.E., McGeehan, J.M., Sy, M.S., Greenspan, N.S., Kaplan, D., Wang, G.X., Parchi, P., Hoover, E.A., Kneale, G., Telling, G., Surewicz, W., Kong, Q., Guo, J.   +19 more
openaire   +3 more sources

A Photothermal‐Responsive PRP‐Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds

Advanced Science, EarlyView.
A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu, Hui‐Yun Gu, Si‐Min Zeng, Chang‐Jiang Liu, Xiao Yan, Ting Pan, Chao Jian, Xian‐Zheng Zhang, Ai‐Xi Yu   +8 more
wiley   +1 more source

PRP Augmentation for ACL Reconstruction [PDF]

BioMed Research International, 2015
Current research is investigating new methods to enhance tissue healing to speed up recovery time and decrease the risk of failure in Anterior Cruciate Ligament (ACL) reconstructive surgery. Biological augmentation is one of the most exploited strategies, in particular the application of Platelet Rich Plasma (PRP).
ANDRIOLO, LUCA, DI MATTEO, BERARDO, KON, ELIZAVETA, FILARDO, GIUSEPPE, Venieri, G., MARCACCI, MAURILIO   +5 more
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Role and Efficacy of L-PRFmatrix in the Regeneration of Periodontal Defect: a New Perspective [PDF]

Journal of Clinical and Diagnostic Research, 2014
The ultimate goal of periodontal therapy is to achieve complete wound healing and regeneration of the periodontal unit. The therapeutic use of L-PRF matrix constitutes a relatively new biotechnology that has been a breakthrough in the acceleration of ...
Anuroopa P, Padmavathi Patil, Vinaya Kumar R, Krishna Kripal   +3 more
doaj   +1 more source

Conformational Properties of β-PrP [PDF]

Journal of Biological Chemistry, 2009
Prion propagation involves a conformational transition of the cellular form of prion protein (PrPC) to a disease-specific isomer (PrPSc), shifting from a predominantly alpha-helical conformation to one dominated by beta-sheet structure. This conformational transition is of critical importance in understanding the molecular basis for prion disease. Here,
Hosszu, Laszlo L P, Trevitt, Clare R., Jones, Samanthan, Batchelor, Mark, Scott, David J., Jackson, Graham S., Collinge, John, Waltho, Jonathan P., Clarke, Anthony R.   +8 more
openaire   +2 more sources