Results 171 to 180 of about 1,553,593 (211)

Ultrastructural localization of cellular prion protein (PrPc) at the neuromuscular junction

Journal of Neuroscience Research, 1999
We examined the localization of the normal cellular isoform of prion protein (PrPc) in mammalian skeletal muscle. Using two anti-PrP antibodies, the neuromuscular junction (NMJ) was preferentially stained after immunohistofluorescence. The mouse, hamster, and human NMJ displayed a fluorescent signal specific for PrPc.
Gohel, C., Grigoriev, V., Escaig-Haye, F., Lasmezas, C.I., Deslys, J.P., Langeveld, J., Akaaboune, M., Hantai, D., Fournier, J.G.   +8 more
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Polymorphism In The PrPC Prion Protein Gene In Pigs

2023
Protein coding regions of the PrPC gene in 51 pigs belonging to 3 breeds namely Hampshire, Yorkshire, Blue Butt Cross (blue spotted cross from a Hampshire X Yorkshire), and a wild pig were studied. These breeds are used nationwide for commercial purposes. The PrPC gene of the pigs that code for prion proteins were sequenced and studied.
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Distribution of the cellular prion protein (PrPC) in brains of livestock and domesticated species

Acta Neuropathologica, 2006
In transmissible spongiform encephalopathies (TSEs) the prion protein (PrP) plays a central role in pathogenesis. The PrP gene (Prnp) has been described in a number of mammalian and avian species and its expression product, the cellular prion protein (PrP(C)), has been mapped in brains of different laboratory animals (rodent and non-human primates ...
Díaz-San Segundo, F, Salguero, FJ, de Avila, A, Espinosa, JC, Torres, JM, Brun, A   +5 more
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Platelet Cellular Prion Protein (PRPC) Is Associated with alpha Granules.

Blood, 2004
Abstract The cellular prion protein (PrPc) is a membrane glycoprotein expressed on many human cells including blood platelets. We have previously shown that human platelets rapidly up-regulate PrPc on their plasma membranes after activation (Holada et al., Br J Haematol.1998;103(1):276–82.).
Karel Holada, Adela Brouckova, Jan Simak, William A. Gahl, Jaroslav G. Vostal   +4 more
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Spontaneous conversion of PrPC to PrPSc [PDF]

FEBS Letters, 1992
Octa-repeats of prion proteins (PrP) contain histidine and tryptophan residues which are known to function as ligands for transition metals. It is proposed that the spontaneous conversion of the PrPC (cellular) isoform into PrPSc (scrapie) isoform may be
Eugene Sulkowski, E Sulkowski
exaly   +2 more sources

[Functions of prion protein PrPc].

Medecine sciences : M/S, 2007
It is now well established that both normal and pathological (or scrapie) isoforms of prion protein, PrPc and PrPsc respectively, are involved in the development and progression of various forms of neurodegenerative diseases, including scrapie in sheep, bovine spongiform encephalopathy (or "mad cow disease") and Creutzfeldt-Jakob disease in human ...
Sylvie, Cazaubon, Pedro, Viegas, Pierre-Olivier, Couraud   +2 more
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Preliminary results of human PrPC protein studied by spectroscopic techniques

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2017
Abstract Neurodegenerative diseases are one of the malfunctions of human nervous system, being a class of complex and prominent pathologies. The human prion Protease Resistant Protein (PrP) is protein regulating copper metabolism in mammalian cells through binding of Cu(II) ions to specific fragments. Nowadays misfolding of this protein is associated
Nowakowski, Michał, Czapla-Masztafiak, Joanna, Kozak, Maciej, Zhukov, Igor, Zhukova, Lilia, Szlachetko, Jakub, Kwiatek, Wojciech M.   +6 more
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Distribution and submicroscopic immunogold localization of cellular prion protein (PrPc) in extracerebral tissues

Cell and Tissue Research, 1998
In transmissible spongiform encephalopathies (TSE), such as scrapie in animals and Creutzfeldt-Jakob disease in humans, the central event is the conversion of a host-encoded amyloidogenic protein (PrPc) into an abnormal isoform (PrPsc) that accumulates as amyloid in TSE brain.
J G, Fournier, F, Escaig-Haye, T, Billette de Villemeur, O, Robain, C I, Lasmézas, J P, Deslys, D, Dormont, P, Brown   +7 more
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The normal cellular prion protein (PrPc) is strongly expressed in bovine endocrine pancreas

Histochemistry and Cell Biology, 2005
Expression of the cellular prion protein (PrP(c)) has been shown to be crucial for the development of transmissible spongiform encephalopathies and for the accumulation of the disease-associated conformer (PrP(sc)) in the brain and other tissues. One of the emerging hypotheses is that the conversion phenomenon could take place at the site where the ...
W M, Amselgruber, M, Büttner, T, Schlegel, M, Schweiger, E, Pfaff   +4 more
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Expression of Cellular Prion Protein (PrPc) on Human Red Blood Cells.

Blood, 2005
Abstract Two recent UK cases of vCJD transmission by blood transfusion emphasize urgent need of donor screening test for prion diseases. Pathological form of prion protein, PrPsc, is currently the only specific marker of prion diseases, but its detection in blood poses significant challenge.
Martin Panigaj, Adela Brouckova, Hana Glierova, Karel Holada   +3 more
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