Results 11 to 20 of about 123,662 (255)

Uremic pruritus: pathophysiology, clinical presentation, and treatments

Kidney Research and Clinical Practice, 2022
Uremic pruritus is one of the most common and bothersome symptoms in patients with end-stage renal disease. Most patients with uremic pruritus experience a prolonged and relapsing course and significant impairments of quality of life. The pathophysiology
Mei-Ju Ko, Yu-Sen Peng, Hon-Yen Wu
semanticscholar   +1 more source

Uremic Pruritus: From Diagnosis to Treatment

Diagnostics, 2022
Uremic pruritus, or chronic kidney disease-associated pruritus, is common, bothersome, and sometimes debilitating in patients with chronic kidney disease or end-stage renal disease.
An-Yu Cheng, L. Wong
semanticscholar   +1 more source

Scratching increases epidermal neuronal branching and alters psychophysical testing responses in atopic dermatitis and brachioradial pruritus

Frontiers in Molecular Neuroscience, 2023
BackgroundChronic scratching imposes a major stress on the skin and can lead to itch intensity worsening, and consequently, patients may enter an itch–scratch cycle.
Lina Renkhold, Henning Wiegmann, Bettina Pfleiderer, Aysenur Süer, Claudia Zeidler, Manuel P. Pereira, Manuel P. Pereira, Martin Schmelz, Sonja Ständer, Konstantin Agelopoulos   +9 more
doaj   +1 more source

Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus.

New England Journal of Medicine, 2020
BACKGROUND Nemolizumab is a subcutaneously administered humanized monoclonal antibody against interleukin-31 receptor A, which is involved in pruritus and inflammation in atopic dermatitis.
K. Kabashima, T. Matsumura, Hiroshi Komazaki, M. Kawashima   +3 more
semanticscholar   +1 more source

Chronic Kidney Disease-Associated Pruritus

Toxins, 2021
Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients.
P. Agarwal, V. Garg, Priyanka Karagaiah, J. Szepietowski, S. Grabbe, M. Goldust   +5 more
semanticscholar   +1 more source

Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate‐to‐severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long‐term studies

British Journal of Dermatology, 2021
Interleukin (IL)‐31 affects the inflammatory response, is involved in epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus.
K. Kabashima, T. Matsumura, H. Komazaki, M. Kawashima   +3 more
semanticscholar   +1 more source

S2k guideline: Diagnosis and treatment of chronic pruritus

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2022
Pruritus is a cross‐disciplinary leading symptom of numerous diseases and represents an interdisciplinary diagnostic and therapeutic challenge. In contrast to acute pruritus, chronic pruritus (CP) is a symptom of various diseases that is usually ...
S. Ständer, C. Zeidler, M. Augustin, U. Darsow, Andreas E. Kremer, F. Legat, S. Koschmieder, J. Kupfer, T. Mettang, M. Metz, A. Nast, U. Raap, G. Schneider, H. Ständer, M. Streit, C. Schut, E. Weisshaar   +16 more
semanticscholar   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, 2022
Background and Aims: Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, M. Khoshdeli, M. Peach, J. Chuang, Julie Lin, Wen-Wei Tsai, S. Mahadevan, Wesley C. Minto, L. Diehl, Ruchi Gupta, M. Trauner, K. Patel, M. Noureddin, K. Kowdley, A. Gulamhusein, C. Bowlus, Ryan S. Huss, R. Myers, C. Chung, A. Billin   +20 more
semanticscholar   +1 more source

Pruritus in Keloid Scars: Mechanisms and Treatments

Acta Dermato-Venereologica, 2021
Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of
A. Hawash, G. Ingrasci, K. Nouri, G. Yosipovitch   +3 more
semanticscholar   +1 more source

Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis

Liver international (Print), 2021
Primary biliary cholangitis (PBC) can result in life‐altering cholestatic pruritus and fatigue, but treatment options are limited. Seladelpar, a peroxisome proliferator‐activated receptor‐delta (PPARδ) agonist, has demonstrated potent anti‐cholestatic ...
A. Kremer, M. Mayo, G. Hirschfield, C. Levy, C. Bowlus, David E. J. Jones, A. Steinberg, C. McWherter, Yun-Jung Choi   +8 more
semanticscholar   +1 more source