Results 251 to 260 of about 119,934 (290)

A phase IIb single‐center study to assess the efficacy of apremilast for the treatment of nummular eczema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background The pathogenesis of nummular eczema (NE) remains unclear, and no targeted therapy has been approved. Apremilast is a small molecule inhibitor targeting phosphodiesterase‐4. Patients and Methods A phase IIb randomized, double‐blind, placebo‐controlled study evaluating the effects of apremilast or placebo in patients with NE.
Alexander Böhner, Peter Seiringer, Viktoria Kleeberger, Danielle Rogner, Christian Oesterlin, Tilo Biedermann, Kilian Eyerich, Felix Lauffer   +7 more
wiley   +1 more source

Emerging Therapies in the Treatment of Prurigo Nodularis: Biological Therapy and Systematic Review of Literature. [PDF]

Dermatol Ther (Heidelb)
Licata G, Arisi M, Giorgio CM, Ariasi C, Tomasi C, Soglia S, Mezzana S, Galli B, Artelli GL, Rossi M, Catapano C.   +10 more
europepmc   +1 more source

Distinct Cytokine Profiles in Chronic Spontaneous Urticaria Refractory to H1‐Antihistamines Compared to Healthy Controls

Clinical &Experimental Allergy, EarlyView.
Young‐Min Ye, Hyun‐Young Lee, Da‐Hye Moon, Kun‐Woo Park, Se‐Min Park   +4 more
wiley   +1 more source

Endoscopic management of primary sclerosing cholangitis

Digestive Endoscopy, EarlyView.
Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has high sensitivity and specificity ...
Suguru Mizuno, Yoshihito Uchida, Satsuki Ando, Masamitsu Nakao, Kayoko Sugawara, Nobuaki Nakayama, Yukinori Imai, Tomoaki Tomiya, Satoshi Mochida   +8 more
wiley   +1 more source

Comparative Efficacy of Ustekinumab and Guselkumab in Improving Itch in Severe Psoriasis Patients. [PDF]

Ann Dermatol
Ryoo JH, Ha NG, Jung HJ, Ha DL, Kim JY, Lee WJ, Jang YH.   +6 more
europepmc   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Chronic Pruritus in Geriatric Patients: Prevalence, Associated Factors, and Itch-related Quality of Life. [PDF]

Acta Derm Venereol
Günther M, Kobus C, Perner C, Schönenberg A, Prell T.   +4 more
europepmc   +1 more source

Postmarketing safety of migraine prophylactic monoclonal antibodies: An EudraVigilance database analysis of eptinezumab, fremanezumab, galcanezumab, and erenumab

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to evaluate the postmarketing safety of monoclonal antibodies (mAbs) targeting the calcitonin gene‐related peptide pathway used for migraine prophylaxis through pharmacovigilance data analysis by examining suspected adverse events reported in Europe.
Victoria Nikitina, Greta Santi Laurini, Nicola Montanaro, Domenico Motola   +3 more
wiley   +1 more source

Topical JAK (Janus Kinase) Inhibitor Therapy for Chronic External Otitis in Atopic Dermatitis: A Case Report. [PDF]

Cureus
Hirano K, Hirano Y, Yu M, Tei Y, Shimane T.   +4 more
europepmc   +1 more source

Validation of PBC‐10 in Japanese patients with primary biliary cholangitis

Hepatology Research, EarlyView.
This study validates the Japanese version of the PBC‐10, a short‐form health‐related quality of life (HRQOL) assessment tool for patients with primary biliary cholangitis (PBC). The findings confirm its reliability and strong correlation with the PBC‐40, supporting its use for rapid clinical screening of HRQOL impairments in Japanese patients. Abstract
Akihito Takeuchi, Masanori Abe, Sachiko Furukawa, Tadashi Namisaki, Atsushi Takahashi, Kazumichi Abe, Kentaro Kikuchi, Ryo Miura, Naoko Tachizawa, Yoshinari Asaoka, Akinobu Takaki, Yoshiyuki Ueno, Akira Honda, Shuji Terai, Atsumasa Komori, Hiromasa Ohira, Hitoshi Yoshiji, Atsuko Yonezawa, Atsushi Tanaka   +18 more
wiley   +1 more source