Results 151 to 160 of about 10,430 (185)

Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord. [PDF]

Nat Commun
Tucker A, Baltazar A, Eisdorfer JT, Thackray JK, Vo K, Thomas H, Tandon A, Moses J, Singletary B, Gillespie T, Smith A, Pauken A, Nadella S, Pitonak M, Letchuman S, Jang J, Totty M, Jalufka FL, Aceves M, Adler AF, Maren S, Blackmon H, McCreedy DA, Abraira V, Dulin JN.   +24 more
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Epigenetic control of PRV-1 expression on neutrophils

Experimental Hematology, 2007
Polycythemia rubra vera-1 (PRV-1) is a GPI-linked protein that is expressed on a subgroup of neutrophils. The number of PRV-1-expressing neutrophils increases in pregnancy and sepsis, or after administration of granulocyte colony-stimulating factor. Expression of the PRV-1 gene is also increased in patients with polycythemia vera (PV) and essential ...
Jaroslav, Jelinek, Jun, Li, Zakar, Mnjoyan, Jean-Pierre J, Issa, Josef T, Prchal, Vahid, Afshar-Kharghan   +5 more
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PRV-1 mRNA expression discriminates two types of essential thrombocythemia

Annals of Hematology, 2004
Essential thrombocythemia (ET) is a heterogeneous disorder. For example, the growth of erythropoietin-independent erythroid colonies, termed "endogenous erythroid colonies (EECs)", has previously been observed in only 50% of ET patients. We have recently described the overexpression of a hematopoietic receptor, PRV-1 (polycythemia rubra vera-1), in ...
Grießhammer, Martin, Klippel, Steffen, Strunck, Elisabeth, Temerinac, Snezana, Mohr, Ursula, Heimpel, Hermann, Pahl, Heike-L.   +6 more
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The PRV-1 gene expression in essential thrombocythemia

Blood, 2004
Recently, Temerinac and colleagues[1][1] found that the polycythemia rubra vera receptor-1 (PRV-1) m-RNA is increased in granulocytes of patients with polycythemia vera (PV) and in some cases of essential thrombocythemia (ET).
Teofili, Luciana, Martini, Maurizio, Guidi, Francesco, Venditti, Daniela, Leone, Giuseppe, Larocca, Luigi Maria   +5 more
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Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis

Blood, 2003
To date, the diagnosis of polycythemia vera (PV) relies on clinical criteria. We have recently described the overexpression of a hematopoietic receptor, polycythemia rubra vera-1 (PRV-1), in patients with PV. Here, we report a quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) assay for the measurement of PRV-1 mRNA levels.
Steffen, Klippel, Elisabeth, Strunck, Snezana, Temerinac, Anthony J, Bench, Gerold, Meinhardt, Ursula, Mohr, Rosi, Leichtle, Anthony R, Green, Martin, Griesshammer, Hermann, Heimpel, Heike L, Pahl   +10 more
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Neutrophil and Eosinophil PRV-1 Expression in Atypical Myeloproliferative Disorders.

Blood, 2004
Abstract Background : Neutrophil PRV-1 over-expression has been strongly associated with polycythemia vera (PV) and its quantitative measurement might complement the diagnostic distinction between PV and secondary polycythemia (Klippel et al. Blood2003;102:3569).
Shireen Sirhan, Terra L. Lasho, Michelle A. Elliott, Ayalew Tefferi   +3 more
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Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia.

Methods in molecular medicine, 2006
The polycythemia rubra vera 1 gene (PRV-1), a member of the urokinase-type plasminogen activator receptor superfamily, is overexpressed in granulocytes isolated from the peripheral blood of patients with polycythemia vera (PV) and essential thrombocythemia (ET).
Martini, Maurizio, Teofili, Luciana, Larocca, Luigi Maria   +2 more
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PRV‐1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia

British Journal of Haematology, 2004
SummaryFemales with the monoclonal type of essential thrombocythaemia (ET), based on the X‐chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namely PRV‐1 overexpression ...
VANNUCCHI, ALESSANDRO MARIA, A. Grossi, PANCRAZZI, ALESSANDRO, E. Antonioli, GUGLIELMELLI, PAOLA, F. Balestri, M. Biscardi, S. Bulgarelli, G. Longo, C. Graziano, L. Gugliotta, BOSI, ALBERTO   +11 more
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Diagnostic Utility of PRV-1 mRNA Quantification in Polycythemia Vera and Essential Thrombocythemia.

Blood, 2004
Abstract In recent reports, granulocyte PRV-1 mRNA has been shown to be over-expressed in the majority of polycythemia vera (PV) patients and with a variable frequency in essential thrombocythemia (ET) patients. Here we evaluate PRV-1 mRNA quantification in the diagnosis of PV and ET.
Arnold Criel, Achiel Van Hoof, Melanny Hidajat, Kurt Geldhof, Dominik Selleslag, Friedel Nollet, Jan Van Droogenbroeck, Sofie Tilleman, Johan Billiet   +8 more
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Neutrophil PRV-1 expression across the chronic myeloproliferative disorders and in secondary or spurious polycythemia

Blood, 2004
Abstract Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). To validate as well as expand upon this novel observation, we conducted a prospective study of 88 subjects: 30 with PV, 22 with SP, 14 with ...
Ayalew, Tefferi, Terra L, Lasho, Alexandra P, Wolanskyj, Ruben A, Mesa   +3 more
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