Results 161 to 170 of about 10,551 (189)

Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia.

Methods in molecular medicine, 2006
The polycythemia rubra vera 1 gene (PRV-1), a member of the urokinase-type plasminogen activator receptor superfamily, is overexpressed in granulocytes isolated from the peripheral blood of patients with polycythemia vera (PV) and essential thrombocythemia (ET).
Martini, Maurizio, Teofili, Luciana, Larocca, Luigi Maria   +2 more
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PRV‐1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia

British Journal of Haematology, 2004
SummaryFemales with the monoclonal type of essential thrombocythaemia (ET), based on the X‐chromosome inactivation pattern (XCIP), have previously been shown to present a higher incidence of thrombosis than polyclonal ones. We aimed to assess correlations between XCIP, thrombosis, and three epigenetic markers of ET, namely PRV‐1 overexpression ...
VANNUCCHI, ALESSANDRO MARIA, A. Grossi, PANCRAZZI, ALESSANDRO, E. Antonioli, GUGLIELMELLI, PAOLA, F. Balestri, M. Biscardi, S. Bulgarelli, G. Longo, C. Graziano, L. Gugliotta, BOSI, ALBERTO   +11 more
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Diagnostic Utility of PRV-1 mRNA Quantification in Polycythemia Vera and Essential Thrombocythemia.

Blood, 2004
Abstract In recent reports, granulocyte PRV-1 mRNA has been shown to be over-expressed in the majority of polycythemia vera (PV) patients and with a variable frequency in essential thrombocythemia (ET) patients. Here we evaluate PRV-1 mRNA quantification in the diagnosis of PV and ET.
Arnold Criel, Achiel Van Hoof, Melanny Hidajat, Kurt Geldhof, Dominik Selleslag, Friedel Nollet, Jan Van Droogenbroeck, Sofie Tilleman, Johan Billiet   +8 more
openaire   +1 more source

Neutrophil PRV-1 expression across the chronic myeloproliferative disorders and in secondary or spurious polycythemia

Blood, 2004
Abstract Recent studies have demonstrated neutrophil overexpression of the polycythemia rubra vera-1 (PRV-1) gene in polycythemia vera (PV) but not in secondary or spurious polycythemia (SP). To validate as well as expand upon this novel observation, we conducted a prospective study of 88 subjects: 30 with PV, 22 with SP, 14 with ...
Ayalew, Tefferi, Terra L, Lasho, Alexandra P, Wolanskyj, Ruben A, Mesa   +3 more
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Expression of PRV-1 Decreases Dependency of Cells on Growth Factors for Proliferation.

Blood, 2004
Abstract Polycythemia rubra vera-1 (PRV-1) is a GPI-linked protein expressed on surface of neutrophils. Polycythemia vera and essential thrombocythemia were found to be associated with an increase in the level of PRV-1 mRNA; however, the function of PRV-1 remains unknown. We have studied the functional effect of expression of PRV-1, both
Vahid Afshar-Kharghan, Jun Li, Zakar Mnjoyan   +2 more
openaire   +1 more source

Clinical Utility of PRV-1 mRNA Expression Levels in Polycythemia Vera and Essential Thrombocythemia.

Blood, 2012
Abstract Abstract 2846 Background: PRV-1 mRNA is overexpressed in most patients with polycythemia vera (PV) and a part of patients with essential thrombocythemia (ET). It is well known that PRV-1 expression levels correlate with JAK2 V617F mutation. While it was reported that JAK2 V617F
Hung Chang, Yu-Shin Hung, Chia-Hui Chang, Yu-Hui Huang, Tung-Liang Lin, Tung-Huei Lin, Po Dunn, Jin-Hou Wu, Po-Nan Wang, Ming-Chung Kuo, Tzung-Chih Tang, Lee-Yung Shih   +11 more
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The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients

Blood, 2005
AbstractRecently, a Jak2V617F mutation has been described in the vast majority of patients with polycythemia vera (PV) as well as in subsets of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). The question arises whether this mutation is observed in those patients with ET and IMF who have also displayed previously ...
Philipp S, Goerttler, Cordula, Steimle, Edith, März, Peter L, Johansson, Björn, Andreasson, Martin, Griesshammer, Heinz, Gisslinger, Hermann, Heimpel, Heike L, Pahl   +8 more
openaire   +3 more sources

Correlation of JAK2 Mutation and PRV-1 and WT1 Transcript Amount in Myeloproliferative Disorders.

Blood, 2005
Abstract Recently, a JAK2V617F mutation has been described in the majority of patients with polycythemia vera (PV), and in a subset of patients with essential thromocythemia (ET) and idiopathic myelofibrosis (IMF). Similarly, PRV-1 has been found overexpressed in many of these patients. The aim of the study was to correlate PRV-1 and WT1
Daniela Cilloni, Giuseppe Saglio, Francesco Iuliano, Giovanni Martinelli, Renata Catalano, Valentina Rosso, Ilaria Defilippi, Paola Sterpone, Francesca Messa, Francesca Arruga, Enrico Gottardi, Sonia Carturan, Anna Serra   +12 more
openaire   +1 more source

Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F

Annals of Hematology, 2007
Three consecutive polycythemia vera (PV) patients were analyzed before and during pegylated-interferon (rIFNalpha) treatment for the following markers: (1) granulocyte and CD34(+) cell clonality, (2) Jak2V617F expression, (3) PRV-1 mRNA overexpression, and (4) Epo-independent colony (EEC) growth.
Steimle, Cordula, Lehmann, Ulrich, Temerinac, Snezana, Goerttler, Philipp, Kreipe, Hans, Meinhardt, Gerold, Heimpel, Hermann, Pahl, Heike-L.   +7 more
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JAK2 V617F MUTATION AND PRV-1 OVEREXPRESSION: RELEVANCE IN THE DIAGNOSIS OF POLYCYTHAEMIA VERA AND ESSENTIAL THROMBOCYTHAEMIA

Acta Clinica Belgica, 2009
In the diagnosis of polycythaemia vera and essential thrombocythaemia, two molecular markers were described in the last decade: the overexpression of the PRV-1 gene and the V617F mutation in the JAK2 gene. In this study we assess their usefulness by comparing our test results with the available clinical data.
S, Melis, S, Vellinga, P, Zachée, A C, Sierens, P J J C, De Schouwer   +4 more
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