Results 161 to 170 of about 10,430 (185)

Expression of PRV-1 Decreases Dependency of Cells on Growth Factors for Proliferation.

Blood, 2004
Abstract Polycythemia rubra vera-1 (PRV-1) is a GPI-linked protein expressed on surface of neutrophils. Polycythemia vera and essential thrombocythemia were found to be associated with an increase in the level of PRV-1 mRNA; however, the function of PRV-1 remains unknown. We have studied the functional effect of expression of PRV-1, both
Vahid Afshar-Kharghan, Jun Li, Zakar Mnjoyan   +2 more
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Clinical Utility of PRV-1 mRNA Expression Levels in Polycythemia Vera and Essential Thrombocythemia.

Blood, 2012
Abstract Abstract 2846 Background: PRV-1 mRNA is overexpressed in most patients with polycythemia vera (PV) and a part of patients with essential thrombocythemia (ET). It is well known that PRV-1 expression levels correlate with JAK2 V617F mutation. While it was reported that JAK2 V617F
Hung Chang, Yu-Shin Hung, Chia-Hui Chang, Yu-Hui Huang, Tung-Liang Lin, Tung-Huei Lin, Po Dunn, Jin-Hou Wu, Po-Nan Wang, Ming-Chung Kuo, Tzung-Chih Tang, Lee-Yung Shih   +11 more
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The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients

Blood, 2005
AbstractRecently, a Jak2V617F mutation has been described in the vast majority of patients with polycythemia vera (PV) as well as in subsets of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). The question arises whether this mutation is observed in those patients with ET and IMF who have also displayed previously ...
Philipp S, Goerttler, Cordula, Steimle, Edith, März, Peter L, Johansson, Björn, Andreasson, Martin, Griesshammer, Heinz, Gisslinger, Hermann, Heimpel, Heike L, Pahl   +8 more
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Correlation of JAK2 Mutation and PRV-1 and WT1 Transcript Amount in Myeloproliferative Disorders.

Blood, 2005
Abstract Recently, a JAK2V617F mutation has been described in the majority of patients with polycythemia vera (PV), and in a subset of patients with essential thromocythemia (ET) and idiopathic myelofibrosis (IMF). Similarly, PRV-1 has been found overexpressed in many of these patients. The aim of the study was to correlate PRV-1 and WT1
Daniela Cilloni, Giuseppe Saglio, Francesco Iuliano, Giovanni Martinelli, Renata Catalano, Valentina Rosso, Ilaria Defilippi, Paola Sterpone, Francesca Messa, Francesca Arruga, Enrico Gottardi, Sonia Carturan, Anna Serra   +12 more
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Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F

Annals of Hematology, 2007
Three consecutive polycythemia vera (PV) patients were analyzed before and during pegylated-interferon (rIFNalpha) treatment for the following markers: (1) granulocyte and CD34(+) cell clonality, (2) Jak2V617F expression, (3) PRV-1 mRNA overexpression, and (4) Epo-independent colony (EEC) growth.
Steimle, Cordula, Lehmann, Ulrich, Temerinac, Snezana, Goerttler, Philipp, Kreipe, Hans, Meinhardt, Gerold, Heimpel, Hermann, Pahl, Heike-L.   +7 more
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JAK2 V617F MUTATION AND PRV-1 OVEREXPRESSION: RELEVANCE IN THE DIAGNOSIS OF POLYCYTHAEMIA VERA AND ESSENTIAL THROMBOCYTHAEMIA

Acta Clinica Belgica, 2009
In the diagnosis of polycythaemia vera and essential thrombocythaemia, two molecular markers were described in the last decade: the overexpression of the PRV-1 gene and the V617F mutation in the JAK2 gene. In this study we assess their usefulness by comparing our test results with the available clinical data.
S, Melis, S, Vellinga, P, Zachée, A C, Sierens, P J J C, De Schouwer   +4 more
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Neutrophil PRV-1 mRNA Overexpression in Chronic Idiopathic Myelofibrosis May Be Associated with Poor Prognosis.

Blood, 2004
Abstract Neutrophil PRV-1 mRNA is overexpressed in nearly all patients with polycythemia vera (PV) and discriminates PV from secondary polycythemia. In addition, 40– 50% of patients with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (cIMF) overexpress PRV-1.
Heike L. Pahl, Juergen Thiele, Alexandra Kaider, Mathias Kees, Hermann Heimpel, Steffen Klippel, Heinz Gisslinger   +6 more
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PRV-1 Interacts with the Cytoplasmic Domain of Mpl and Interferes with TPO-Induced Signaling Cascades.

Blood, 2006
Abstract Polycythemia rubra vera-1 (PRV-1) is a member of the uPAR/CD59/Ly6 family of cell surface receptors. An increase in the expression level of PRV-1 mRNA has been shown in patients with polycythemia vera and essential thrombocythemia, however, the ligand and function of PRV-1 remains unclear.
Brian J. Lannutti, Jennifer N. Minear, Manish Ghandi, Jan Johnson   +3 more
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Clinical and Laboratory Correlative Studies of Neutrophil PRV-1 Expression: A Prospective Study in 141 Subjects.

Blood, 2004
Abstract Background : Controversy persists regarding diagnostic accuracy as well as added value for quantitative assessment of neutrophil PRV-1 expression in polycythemia vera (Klippel et al. Blood2003;102:3569; Tefferi et al. Blood2004;103:3547).
Shireen Sirhan, Terra L. Lasho, Ayalew Tefferi   +2 more
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Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera

Blood, 2002
The cDNA for polycythemia rubra vera 1 (PRV-1), a novel hematopoietic receptor, was recently cloned by virtue of its overexpression in patients with polycythemia vera. PRV-1 is a member of the uPAR/CD59/Ly6 family of cell surface receptors, which share a common cysteine-rich domain and are tethered to the cell surface via a glycosylphosphatidylinositol
Steffen, Klippel, Elisabeth, Strunck, Christian E, Busse, Dirk, Behringer, Heike L, Pahl   +4 more
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