Results 171 to 180 of about 10,430 (185)

Quantification of intrahost genetic diversity of Piscine Orthoreovirus (PRV-1) infecting Atlantic and Chinook salmon

2022
The decline in populations of wild Pacific salmon is of great concern given their importance to Indigenous Peoples of Canada, Pacific Northwest ecosystems, and commercial fisheries. Contagious diseases may contribute to these losses. Piscine orthoreovirus 1 (PRV-1) is a pathogen recently linked to Heart and Skeletal Muscle Inflammation (HSMI) in farmed
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Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera

Blood, 2000
AbstractPolycythemia vera (PV) is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. Although it has been shown that progenitor cells of patients with PV are hypersensitive to several growth factors, the molecular pathogenesis of this disease remains unknown.
Temerinac, Snezana, Klippel, Steffen, Strunck, Elisabeth, Roder, S., Lübbert, Michael, Lange, Winand, Azémar, Marc, Meinhardt, Gerold, Schaefer, H. Martin, Pahl, Heike-L.   +9 more
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Increased Expression of the PRV-1 Gene in Thalassemia Reflects the Rate of the Underlying Erythropoietic Activity.

Blood, 2005
Abstract Over the last years, PRV-1 expression has been considered to be closely connected with polycythemia vera (PV). However, the precise function of the PRV-1 protein has never been clarified while the search for the pathogenetic mechanism of PV has shifted to the association between the PRV-1 gene and the JAK2 V617F mutation rather ...
Dimitris Loukopoulos, Evangelos Terpos, Ersi Voskaridou, Christine Zoi, Katerina Zoi   +4 more
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[New molecular markers within the chronic myeloproliferative disorders. I: the PRV-1 gene].

Ugeskrift for laeger, 2006
PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis
Thomas Stauffer, Larsen, Niels, Pallisgaard, Jacob Haaber, Christensen, Paul, Gram-Hansen, Gitte B, Kerndrup, Michael Boe, Møller, Hans Carl, Hasselbalch   +6 more
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Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines

Leukemia Research, 2008
Prv-1 is a hematopoietic cell surface receptor that has been shown to be overexpressed in patients diagnosed with polycythemia vera (PV) and essential thrombocythemia (ET), yet its cellular function remains unclear. In this study, we assessed the role of Prv-1 in thrombopoietin (Tpo)/Mpl signaling with the goal of identifying molecular mechanisms which
Megan, Dillon, Jennifer, Minear, Jan, Johnson, Brian J, Lannutti   +3 more
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Comparison of Platelet-Rich Plasma Serotonin Level and Quantitative Neutrophil PRV-1 Assay in Chronic Myeloproliferative Disorders.

Blood, 2004
Abstract In a prospective study of 100 subjects, an ELISA assay was used to measure platelet-rich plasma (PRP) serotonin levels in patients with polycythemia vera (PV; n=26), essential thrombocythemia (ET; n=14), myelofibrosis with myeloid metaplasia (MMM; n=26), secondary or spurious polycythemia (SP; n=20) and controls (n=14 ...
Ayalew Tefferi, Terra L. Lasho, Cody A. Koch   +2 more
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Inconsistencies in the association between the JAK2^V617F mutation and PRV‐1 over‐expression among the chronic myeloproliferative diseases

British Journal of Haematology, 2006
Inconsistencies in the association between the JAK2(V617F) mutation and PRV-1 over-expression among the chronic myeloproliferative diseases.
VANNUCCHI, ALESSANDRO MARIA, GUGLIELMELLI, PAOLA, ANTONIOLI, ELISABETTA, MAPPA, SILVIA, PANCRAZZI, ALESSANDRO, BOGANI, COSTANZA, PONZIANI, VANESSA, BOSI, ALBERTO   +7 more
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The Clinical and PRV-1 Expression Phenotype of Wild-Type, Heterozygous, and Homozygous JAK2 V617F in Polycythemia Vera.

Blood, 2005
Abstract BACKGROUND. Several studies have recently reported on the occurrence of a JAK2 V617F mutation in myeloid cells from the majority of patients with polycythemia vera (PV). The clinical relevance of this novel observation is currently under study.
D. Gary Gilliland, Stephanie J. Lee, Martha Wadleigh, Chin Yang Li, David P. Steensma, Alexandra P. Wolanskyj, Ruben A. Mesa, Michelle A. Elliott, Jacob S. Strand, Susan M. Schwager, Terra L. Lasho, Shireen Sirhan, Ayalew Tefferi   +12 more
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PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera.

Current hematology reports, 2003
During the past 4 years, the first molecular markers for polycythemia vera (PV) have been described. These markers include decreased expression of the thrombopoietin receptor c-Mpl, increased expression of the surface receptor polycythemia rubra vera-I, and insulin-like growth factor-I hypersensitivity.
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Characterization of PRV-1, a Novel Hematopoietic Cell Surface Marker Overexpressed in Polycythemia Rubra Vera

2004
While the pathognomonic mutation causing chronic myeloid leukemia (CML), the “Philadelphia chromosome”, is well characterized, and the detection of the bcr/abl fusion transcript, allows a precise, molecular diagnosis of CML, to date there is no characteristic molecular marker for the diagnosis of polycythemia vera (PV).
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