Results 171 to 180 of about 10,551 (189)

Neutrophil PRV-1 mRNA Overexpression in Chronic Idiopathic Myelofibrosis May Be Associated with Poor Prognosis.

Blood, 2004
Abstract Neutrophil PRV-1 mRNA is overexpressed in nearly all patients with polycythemia vera (PV) and discriminates PV from secondary polycythemia. In addition, 40– 50% of patients with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (cIMF) overexpress PRV-1.
Heike L. Pahl, Juergen Thiele, Alexandra Kaider, Mathias Kees, Hermann Heimpel, Steffen Klippel, Heinz Gisslinger   +6 more
openaire   +1 more source

PRV-1 Interacts with the Cytoplasmic Domain of Mpl and Interferes with TPO-Induced Signaling Cascades.

Blood, 2006
Abstract Polycythemia rubra vera-1 (PRV-1) is a member of the uPAR/CD59/Ly6 family of cell surface receptors. An increase in the expression level of PRV-1 mRNA has been shown in patients with polycythemia vera and essential thrombocythemia, however, the ligand and function of PRV-1 remains unclear.
Brian J. Lannutti, Jennifer N. Minear, Manish Ghandi, Jan Johnson   +3 more
openaire   +1 more source

Clinical and Laboratory Correlative Studies of Neutrophil PRV-1 Expression: A Prospective Study in 141 Subjects.

Blood, 2004
Abstract Background : Controversy persists regarding diagnostic accuracy as well as added value for quantitative assessment of neutrophil PRV-1 expression in polycythemia vera (Klippel et al. Blood2003;102:3569; Tefferi et al. Blood2004;103:3547).
Shireen Sirhan, Terra L. Lasho, Ayalew Tefferi   +2 more
openaire   +1 more source

Biochemical characterization of PRV-1, a novel hematopoietic cell surface receptor, which is overexpressed in polycythemia rubra vera

Blood, 2002
The cDNA for polycythemia rubra vera 1 (PRV-1), a novel hematopoietic receptor, was recently cloned by virtue of its overexpression in patients with polycythemia vera. PRV-1 is a member of the uPAR/CD59/Ly6 family of cell surface receptors, which share a common cysteine-rich domain and are tethered to the cell surface via a glycosylphosphatidylinositol
Steffen, Klippel, Elisabeth, Strunck, Christian E, Busse, Dirk, Behringer, Heike L, Pahl   +4 more
openaire   +3 more sources

Quantification of intrahost genetic diversity of Piscine Orthoreovirus (PRV-1) infecting Atlantic and Chinook salmon

2022
The decline in populations of wild Pacific salmon is of great concern given their importance to Indigenous Peoples of Canada, Pacific Northwest ecosystems, and commercial fisheries. Contagious diseases may contribute to these losses. Piscine orthoreovirus 1 (PRV-1) is a pathogen recently linked to Heart and Skeletal Muscle Inflammation (HSMI) in farmed
openaire   +1 more source

Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera

Blood, 2000
AbstractPolycythemia vera (PV) is a clonal stem cell disorder characterized by hyperproliferation of the erythroid, myeloid, and megakaryocytic lineages. Although it has been shown that progenitor cells of patients with PV are hypersensitive to several growth factors, the molecular pathogenesis of this disease remains unknown.
Temerinac, Snezana, Klippel, Steffen, Strunck, Elisabeth, Roder, S., Lübbert, Michael, Lange, Winand, Azémar, Marc, Meinhardt, Gerold, Schaefer, H. Martin, Pahl, Heike-L.   +9 more
openaire   +2 more sources

Increased Expression of the PRV-1 Gene in Thalassemia Reflects the Rate of the Underlying Erythropoietic Activity.

Blood, 2005
Abstract Over the last years, PRV-1 expression has been considered to be closely connected with polycythemia vera (PV). However, the precise function of the PRV-1 protein has never been clarified while the search for the pathogenetic mechanism of PV has shifted to the association between the PRV-1 gene and the JAK2 V617F mutation rather ...
Dimitris Loukopoulos, Evangelos Terpos, Ersi Voskaridou, Christine Zoi, Katerina Zoi   +4 more
openaire   +1 more source

[New molecular markers within the chronic myeloproliferative disorders. I: the PRV-1 gene].

Ugeskrift for laeger, 2006
PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis
Thomas Stauffer, Larsen, Niels, Pallisgaard, Jacob Haaber, Christensen, Paul, Gram-Hansen, Gitte B, Kerndrup, Michael Boe, Møller, Hans Carl, Hasselbalch   +6 more
openaire   +1 more source

Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines

Leukemia Research, 2008
Prv-1 is a hematopoietic cell surface receptor that has been shown to be overexpressed in patients diagnosed with polycythemia vera (PV) and essential thrombocythemia (ET), yet its cellular function remains unclear. In this study, we assessed the role of Prv-1 in thrombopoietin (Tpo)/Mpl signaling with the goal of identifying molecular mechanisms which
Megan, Dillon, Jennifer, Minear, Jan, Johnson, Brian J, Lannutti   +3 more
openaire   +2 more sources

Comparison of Platelet-Rich Plasma Serotonin Level and Quantitative Neutrophil PRV-1 Assay in Chronic Myeloproliferative Disorders.

Blood, 2004
Abstract In a prospective study of 100 subjects, an ELISA assay was used to measure platelet-rich plasma (PRP) serotonin levels in patients with polycythemia vera (PV; n=26), essential thrombocythemia (ET; n=14), myelofibrosis with myeloid metaplasia (MMM; n=26), secondary or spurious polycythemia (SP; n=20) and controls (n=14 ...
Ayalew Tefferi, Terra L. Lasho, Cody A. Koch   +2 more
openaire   +1 more source