Results 191 to 200 of about 116,358 (261)

Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan   +4 more
wiley   +1 more source

Impact of PSA Nadir on Outcomes in Metastatic Hormone-Sensitive Prostate Cancer: A Systematic Review and Reconstructed Individual Patient Data Meta-analysis. [PDF]

open access: yesTarget Oncol
Di Civita MA   +12 more
europepmc   +1 more source

Tibia‐first, gap‐balanced patient‐specific alignment in total knee arthroplasty achieves better ligament balance than mechanical, kinematic and functional alignment strategies

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study evaluates four different alignment techniques to assess total knee arthroplasty (TKA) balance. Methods A prospective cohort of 400 patients undergoing primary robotic‐assisted cruciate‐retaining TKA was analysed. The Velys TKA robotic system collects a balance curve that enables the surgeon to intraoperatively analyse the ...
Guido Wierer, Mark Clatworthy
wiley   +1 more source

Paediatric Procedural Sedation and Analgesia in Emergency Departments: A Delphi Consensus Study. [PDF]

open access: yesEmerg Med Australas
Cahís N   +7 more
europepmc   +1 more source

Mixed Litter Decomposition Drives Functional Gene Rearrangement in the Microbial Carbon Cycle

open access: yesLand Degradation &Development, EarlyView.
ABSTRACT Understanding how mixed‐species litter decomposition regulates microbial communities and carbon cycling is vital for guiding ecosystem restoration and climate change mitigation, as it is a key process for nutrient cycling and carbon sequestration. A 15‐month field experiment compared single‐species (Pinus sylvestris var.
Jiaying Liu   +6 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik   +3 more
wiley   +1 more source

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