Results 71 to 80 of about 9,621 (218)

Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
PGN strains are generated by the deletion of virulence factor genes. The metabolic pathways and regulatory frameworks that lead to high‐efficiency production of rhamnolipids in P. aeruginosa are preserved in these strains. Therefore, PGN strains are promising bio‐safe cell factories for the industrial production of rhamnolipids.
Parvathy V. Das, Meagan E. Valentine, Timothy E. Long, Hongwei D. Yu   +3 more
wiley   +1 more source

Optimised chronic infection models demonstrate that siderophore ‘cheating’ in Pseudomonas aeruginosa is context specific [PDF]

, 2017
The potential for siderophore mutants of Pseudomonas aeruginosa to attenuate virulence during infection, and the possibility of exploiting this for clinical ends, have attracted much discussion.
A Dötsch, A Folkesson, A Leinweber, A Mund, A Ross-Gillespie, A Ross-Gillespie, A Ross-Gillespie, AD Morgan, AEL Roberts, AL Goodman, Alan McNally, AM Luján, Ana C da Silva, AS Griffin, B Ghysels, B Raymond, BL Price, CK Stover, D De Vos, D Hohnadel, DA D’Argenio, DD Sriramulu, E Banin, E Mowat, E-I Koh, EB Hirsch, ES Cowley, F Harrison, F Harrison, F Harrison, F Harrison, F Harrison, F Harrison, Freya Harrison, H Arai, H Miyazaki, J Fox, J Tyrrell, JM Flynn, JM Gaines, KH Turner, KL Palmer, KL Palmer, KP Rumbaugh, KR Foster, L Yang, M Ghoul, M Ghoul, M Rella, M Vasse, M Werthén, M Whiteley, MA Brockhurst, MJ Wilson, N Jiricny, N Jiricny, NJ Croucher, P Cornelis, PB Rainey, PM Luong, R Kümmerli, R Kümmerli, R Kümmerli, R Kümmerli, R Kümmerli, R Kümmerli, R Kümmerli, RA Quinn, RC Boucher, RC Hunter, RL Marvig, S Kirchner, SB Andersen, SE Darch, SP Brown, SP Diggle, Stephan Heeb, Stephen P Diggle, T Bjarnsholt, T Bjarnsholt, T Hothorn, T Székely, T Van Opijnen, TA Hunt, UA Ochsner, VB Weaver, WD Hamilton, X-X Zhang, Z Dumas, Z Dumas   +89 more
core   +3 more sources

Nanoparticle‐Based Tetracycline Delivery Systems: Advancing Therapeutic Effectiveness and Tackling Antibiotic Resistance

Particle &Particle Systems Characterization, Volume 42, Issue 10, October 2025.
This review explores improved tetracycline (TCN) delivery via polymer‐based nanocarriers to enhance solubility, stability, and targeted release. It also covers stimuli‐responsive systems, triggered by pH, enzymes, or reactive oxygen species (ROS), and co‐delivery approaches that increase therapeutic efficacy in cancer and inflammatory diseases ...
Mahsa Molaei Nasr, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Abbas Rahdar, M. Ali Aboudzadeh   +5 more
wiley   +1 more source

Therapeutic efficacy of Cintredekin Besudotox (IL13-PE38QQR) in murine lung fibrosis is unaffected by immunity to Pseudomonas aeruginosa exotoxin A.

PLoS ONE, 2010
BackgroundWe have previously explored a therapeutic strategy for specifically targeting the profibrotic activity of IL-13 during experimental pulmonary fibrosis using a fusion protein comprised of human IL-13 and a mutated form of Pseudomonas aeruginosa ...
Rogério S Rosada, Ana P Moreira, Fabiani G Frantz, Raj K Puri, Aquilur Rahman, Theodore J Standiford, Carlos R Zárate-Bladés, Célio L Silva, Cory M Hogaboam   +8 more
doaj   +1 more source

Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies

Phytotherapy Research, Volume 39, Issue 10, Page 4444-4473, October 2025.
NPs improve atopic dermatitis mainly include flavonoids, phenols, glycosides, alkaloids, and others. ABSTRACT Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden.
Xinyun Fan, Zibo Liu, Wenjing Yang, Hongying Zhang, Hao Zhong, Yan Pang, Xun Ye, Chunjie Wu, Liang Li   +8 more
wiley   +1 more source

ADP-Ribosylargininyl reaction of cholix toxin is mediated through diffusible intermediates [PDF]

, 2014
Background: Cholix toxin is an ADP-ribosyltransferase found in non-O1/non-O139 strains of Vibrio cholera. The catalytic fragment of cholix toxin was characterized as a diphthamide dependent ADP-ribosyltransferase.
Sung, Vicky M-H, Tsai, Chia-Lun
core   +1 more source

A Catalytic Loop within Pseudomonas aeruginosa Exotoxin A Modulates Its Transferase Activity [PDF]

Journal of Biological Chemistry, 2001
Mutagenesis techniques were used to replace two loop regions within the catalytic domain of Pseudomonas aeruginosa exotoxin A (ETA) with functionally silent polyglycine loops. The loop mutant proteins, designated polyglycine Loops N and C, were both less active than the wild-type enzyme. However, the polyglycine Loop C mutant protein, replaced with the
S P, Yates, A R, Merrill
openaire   +2 more sources

Genomic Analysis and Virulence Features of Vibrio cholerae Non‐O1/Non‐O139 Harbouring CARB‐Type β‐Lactamases From Freshwater Bodies, Argentina

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
Genomic analysis of ampicillin‐resistant Vibrio cholerae non‐O1/non‐O139 from central Argentina's freshwater bodies identified four novel CARB‐β‐lactamase variants linked to the V. cholerae superintegron. An unusual VPI‐1 arrangement encoding the TCP pilus and a type VI secretion system subclass i5 was also found, associated with increased ...
Daiana Guevara Núñez, Fabrizzio N. Morandini, Geehan Suleyman, Kyle Crooker, Jagjeet Kaur, Gina Maki, José L. Bocco, Darío Fernández Do Porto, Markus J. Zervos, Claudia Sola, H. Alex Saka   +10 more
wiley   +1 more source

Molecular Detection of Virulence Genes among Pseudomonas aeruginosa Strains Isolated from Clinical Specimens by Multiplex PCR

پزشکی بالینی ابن سینا, 2018
Background and Objective: Pseudomonas aeroginosa is the most common pathogen associated with nosocomial infections and possesses virulence factors which contribute to the bacterial invasion and toxicity such as alginate, exoenzyme S, exotoxin A and ...
Afsoon Shariat, Sajad Alizadeh, Mehdi Jahangiri Hoseinabadi, Mohammad Movagharnejad   +3 more
doaj  

Characterisation of Pseudomonas aeruginosa related to bovine mastitis [PDF]

, 2013
Pseudomonas aeruginosa is one of the causative pathogens of bovine mastitis. Most P. aeruginosa strains possess the type III secretion system (TTSS), which may increase somatic cell counts (SCCs) in milk from mastitis-affected cows.
Hong, Min, Hwang, Sun, Kim, Jae, Kwon, Ka, Park, Hye, Park, Yong, Park, Young, Shin, Sook, Yoon, Jang   +8 more
core   +1 more source