A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]
PLoS ONE, 2016 Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson +4 more
doaj +11 more sources
Preparation and evaluation of the exotoxin A nano-gold conjugate as a vaccine candidate for Pseudomonas aeruginosa infections [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Pseudomonas aeruginosa is an opportunistic pathogen that is an important cause of nosocomial infections. This bacterium produces various virulence factors, among which exotoxin A is significantly involved in mortality and morbidity. In this
Masoumeh Abbasi +4 more
doaj +1 more source
ISOLATION AND PURIFICATION OF ANTICANCER PROTEIN EXOTXIN A FROM Pseudomonas aeruginosa
The Iraqi Journal of Agricultural science, 2022 Toxins produced from bacteria constitute promising antitumor agents in treating different cancer types. Exotoxin A from Pseudomonas aeruginosa is the highly toxic virulence component that bind to specific cell receptors.
L. Q. Jawad, H. A. R. R. Rasheed
doaj +1 more source
LINK BETWEEN SOME VIRULNCE FACTORS GENES AND ANTIBACTERIAL RESISTANCE OF PSEUDOMONAS AERUGINOSA
The Iraqi Journal of Agricultural science, 2022 The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) and to express their relationship to antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering from otitis externa ...
Aida H. Ibrahim
doaj +1 more source
BMC Infectious Diseases, 2021 Background Pseudomonas aeruginosa is the leading cause of nosocomial infections, especially in people with a compromised immune system. Targeting virulence factors by neutralizing antibodies is a novel paradigm for the treatment of antibiotic-resistant ...
Zahra Shadman +6 more
doaj +1 more source
PCR based identification of exotoxin A-producing Pseudomonas aeroginosa isolated from burn wound infection [PDF]
Trends in Pharmaceutical Sciences, 2022 Exotoxin A (exoA) is a major pathogenic factor in Pseudomonas aeruginosa. This non-fermenting gram-negative bacillus causes a wide range of infections. P. aeruginosa is a major cause of hospital-acquired infections.
Gholamreza Morshedi +9 more
doaj +1 more source
AMB Express, 2021 This work explores the ADP-ribosyltransferase activity of Pseudomonas (P.) aeruginosa exotoxin A using the guanyl hydrazone derivative, nitrobenzylidine aminoguanidine (NBAG) and the impact of gamma radiation on its efficacy.
Radwa N. Morgan +3 more
doaj +1 more source
The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]
, 2016 Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie +2 more
core +2 more sources
Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]
, 2018 Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon +6 more
core +2 more sources
Molecular cloning and expression of novel fibroblast growth factor-2 conjugated with immunodominant domains of pseudomonas exotoxin [PDF]
, 2015 Angiogenesis is very important in cancer growth and metastasis. Basic fibroblast growth factor (bFGF) as one of the most important angiogenesis factors is an attractive target for cancer vaccine.
Farazmandfar, T. +6 more
core +1 more source