Results 51 to 60 of about 6,869 (128)

Membrane-translocating peptides and toxins: from nature to bedside [PDF]

, 2008
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie, Kerkis, Alexandre, Kerkis, Irina, Prieto-Silva, Álvaro Rossan, Rádis-Baptista, Gandhi, Tetsuo, Yamane   +5 more
core   +1 more source

Dissecting HOCl Action in Chronic Wound Biofilms: Proteomic Insights From a Host‐Relevant Model of Pseudomonas aeruginosa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Impact statement: We tested a gel containing a pure, stable form of hypochlorous acid (HOCl) against P. aeruginosa. To ensure our results reflect the true effects of HOCl we used a host‐relevant biofilm model. The HOCl gel disrupted bacterial metabolism, impacted proteins associated with virulence, and changed the abundance antibiotic resistance ...
Lori I. Robins, Philip Gafken, Chenwei Lin, Lisa Jones, Sarah E. Hooper   +4 more
wiley   +1 more source

DETECTION OF ExoT GENE IN LOCAL ISOLATES OF PSEUDOMONAS AUROGINOSA IN A SAMPLE OF BURN INFECTION

The Iraqi Journal of Medical Sciences, 2018
Background: Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic microorganism that requires damaged mucus membranes and epithelial tissues to cause acute infections. It had been stated that P.
Rana A. Hanoon, Ibtisam G. Auda, Ismail H. Aziz   +2 more
doaj   +4 more sources

Comparison of Conventional Culture Methods and Polymerase Chain Reaction (PCR) for Specific Detection of Pseudomonas Aeruginosa

مجله دانشکده پزشکی اصفهان, 2012
Background: Pseudomonas aeruginosa (P. aeruginosa), a major gram-negative opportunistic nosocomial pathogen, is notoriously known because of its intrinsic and acquired multiple antibiotic resistances.
Massumeh Doosti, Mehdi Haj Ojagh Faghihi, Ali Ramazani, Mohammad Reza Saini   +3 more
doaj  

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Frontiers in Immunology, 2020
Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell.
Ronit Mazor, Ira Pastan
doaj   +1 more source

ADP-Ribosylargininyl reaction of cholix toxin is mediated through diffusible intermediates [PDF]

, 2014
Background: Cholix toxin is an ADP-ribosyltransferase found in non-O1/non-O139 strains of Vibrio cholera. The catalytic fragment of cholix toxin was characterized as a diphthamide dependent ADP-ribosyltransferase.
Sung, Vicky M-H, Tsai, Chia-Lun
core   +1 more source

Bioimaging With Fluorescent Nucleic‐Acid Aptamers for the Specific Detection and Quantification of Pseudomonas aeruginosa Alone and in Heterogeneous Bacterial Populations

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Aptamers are promising candidates for diagnostic applications due to their broad pathogen detection capability. The open‐access quantitative bioimaging software we have developed for confocal images has validated aptamer F23 as a promising tool to distinguish Pseudomonas aeruginosa from different bacterial strains. ABSTRACT Aptamers, short nucleic acid
Chaimae Mezouarhi, Romain Vauchelles, Basma Abdallah, Régine Janel, Mouna Ouadghiri, Hassan Ait Benhassou, Sandrine Pelet, Pierre Fechter, Laurence Choulier   +8 more
wiley   +1 more source

A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin.

PLoS ONE, 2010
Diphtheria toxin (DT), Pseudomonas aeruginosa Exotoxin A (ETA) and cholix toxin from Vibrio cholerae share the same mechanism of toxicity; these enzymes ADP-rybosylate elongation factor-2 (EF-2) on a modified histidine residue called diphthamide, leading
Vincent Roy, Karim Ghani, Manuel Caruso
doaj   +1 more source

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.

PLoS Pathogens, 2022
The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity.
Abby R Kroken, Naren Gajenthra Kumar, Timothy L Yahr, Benjamin E Smith, Vincent Nieto, Hart Horneman, David J Evans, Suzanne M J Fleiszig   +7 more
doaj   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source