Results 81 to 90 of about 6,869 (128)
Toxins, 2017 Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury.
Chien-Chao Chiu +7 more
doaj +1 more source
New and emerging therapeutic options for malignant pleural mesothelioma: review of early clinical trials. [PDF]
, 2015 Malignant pleural mesothelioma (MPM) is a rare tumor that is challenging to control. Despite some benefit from using the multimodality-approach (surgery, combination chemotherapy and radiation), survival remains poor. However, current research produced a
Cameron, Robert B +2 more
core +2 more sources
PLoS ONE, 2014 Infections with Pseudomonas aeruginosa have been a long-standing challenge for clinical therapy because of complex pathogenesis and resistance to antibiotics, thus attaching importance to explore effective vaccines for prevention and treatment.
Mingzi Jiang, Jing Yao, Ganzhu Feng
doaj +1 more source
Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A
Toxins, 2016 Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials.
Gilad Kaplan +6 more
doaj +1 more source
In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells
Advanced Biomedical Research, 2017 Background: Angiogenesis which occurs mandatory in solid tumors, is a critical step in malignancy progression. Vascular endothelial growth factor (VEGF) is mainly responsible for angiogenesis process and facilitates the formation of new vessels ...
Jahangir Langari +10 more
doaj +1 more source
Molecules, 2017 The use of human pluripotent stem cells (hPSCs) such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) in regenerative medicine is hindered by their tumorigenic potential.
Hiroaki Tateno +2 more
doaj +1 more source
Isolation Virulence genes ETA, OPrL, gyrB in Pseudomonas aeruginosa clinical samples from hospitals in Kerman by Multiplex-PCR [PDF]
, 2016 زمینه و هدف: سودوموناس آئروژینوزا یک پاتوژن فرصت طلب و عامل عفونت های بیمارستانی و مرگ و میر به خصوص در بیماران با ضعف سیستم ایمنی می باشد و مقاومت ذاتی به مواد ضد میکروبی منجر به مشکلاتی در درمان عفونت های آن می شود.
Amini, K., Kamali, A.
core +1 more source
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen [PDF]
, 2014 A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to
Akcay, Gizem +3 more
core +1 more source
Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer
Toxins, 2016 Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, yet no effective therapeutics exist. This review provides an overview of the recent development of recombinant immunotoxins for the treatment of glypican-3 (GPC3) expressing ...
Bryan D. Fleming, Mitchell Ho
doaj +1 more source