Results 131 to 140 of about 3,746,898 (399)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Pseudomonas aeruginosainfection and exacerbations in bronchiectasis: more questions than answers [PDF]

, 2018
Miguel Ángel Martínez‐García
openalex   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Análise epidemiológica de isolados clínicos de Pseudomonas aeruginosa provenientes de hospital universitário Epidemiologic analysis of clinical isolates of Pseudomonas aeruginosa from an university hospital

Revista Brasileira de Terapia Intensiva, 2009
OBJETIVOS: A Pseudomonas aeruginosa é um patógeno oportunista que tem se destacado quanto à prevalência em casos de infecções hospitalares. Sua ampla resistência aos diversos grupos de antimicrobianos garante a este microrganismo um papel de destaque ...
Eduardo José Valença Cordeiro Pires, Valdemir Vicente da Silva Júnior, Ana Catarina de Souza Lopes, Dyana Leal Veras, Larissa Espíndola Leite, Maria Amélia Vieira Maciel   +5 more
doaj   +1 more source

Pseudomonas Infection in Hospital [PDF]

BMJ, 1967
K. Gullers, A.-S. Malmborg, O. Norlander, B. Nystrom, N. Peterson   +4 more
openaire   +1 more source

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, EarlyView.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients [PDF]

, 2018
Lois W. Martin, Cynthia L. Robson, Annabelle M. Watts, Andrew Gray, Claire Wainwright, Scott C. Bell, Kay A. Ramsay, Timothy J. Kidd, David W. Reid, Ben Brockway, Iain L. Lamont   +10 more
openalex   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Is it Worth Adding Systemic Antibiotics to Inhalational Tobramycin Therapy to Treat Pseudomonas Infections in Cystic Fibrosis? [PDF]

Cureus, 2021
Karki K, Sigdel S, Kafle S.
europepmc   +1 more source

A Survey on Ophthalmia Neonatorum in Benin City, Nigeria (Emphasis on gonococcal ophthalmia) [PDF]

, 2003
The purpose of the study was to investigate the incidence of gonococcal ophthalmia neonatorum considering its ability to lead to childhood blindness through corneal ulceration and scarification.
Enabulele, Dr Onaiwu, Iyamu, Dr Eghosasere   +1 more
core   +1 more source