Results 41 to 50 of about 11,544 (218)

Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant

, 2002
To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory motifs, and of the conventional adjuvants ...
Eddie G. te Lintelo, te Lintelo, E.G., Wim J. A. Boersma, Rooij, E.M.A., van, Yolanda E. de Visser, Boersma, WJA, Lintelo, E.G., te, Boersma, W.J.A., Visser, Y.E., de, Hilgers, LAT, Haagmans, Bart, van Rooij, EMA, Bart L. Haagmans, Bianchi, ATJ, Harrie L. Glansbeek, Hilgers, L.A.T., Haagmans, B.L., Glansbeek, H.L., Andre T. J. Bianchi, van Rooij, E.M.A., Glansbeek, HL, Eugene M. A. van Rooij, de Visser, Y.E., Luuk A. T. Hilgers, Bianchi, A.T.J., Lintelo, EG, de Visser, YE   +26 more
core   +1 more source

Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A case report

International Journal of Infectious Diseases, 2019
We report the case of a patient who presented with viral encephalitis and a pulmonary infection complicated with bilateral acute retinal necrosis after direct contact with diseased swine. Next-generation sequencing of the cerebrospinal fluid and vitreous
Yuwei Wang, Hong Nian, Ziwei Li, Wenjuan Wang, Xin Wang, Yan Cui   +5 more
doaj   +1 more source

Tk-deleted pseudorabies virus retains high pathogenicity in rats

Journal of Veterinary Research, 2021
The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion.
Zhang Lirong, Ruan Keyue, Sang Guoju, Xu Zhaoyang, Tong Wu, Yu Hai, Shan Tongling, Gao Fei, Li Liwei, Kong Ning, Tong Guangzhi, Zheng Hao   +11 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus

BMC Microbiology, 2009
Background Pseudorabies virus (PRV) is an alphaherpesviruses whose native host is pig. PRV infection mainly causes signs of central nervous system disorder in young pigs, and respiratory system diseases in the adult.
Furlong RA, Jafer O, Zhang SJ, Yuan JF, Chausiaux OE, Sargent CA, Zhang GH, Affara NA   +7 more
doaj   +1 more source

A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1/Th2 Immune Responses in Mice

Journal of Immunology Research, 2020
Pseudorabies is an important infectious disease of swine, and immunization using attenuated pseudorabies virus (aPrV) vaccine is a routine practice to control this disease in swine herds.
Yong Wang, Xuemei Cui, Lijia Yuan, Babar Maqbool, Wei Xu, Shanshan He, Ran Guan, Songhua Hu   +7 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Analysis of differential gene expression in the brain tissue transcriptome of Jiangkou radish piglets infected with porcine pseudorabies virus

SAGE Open Medicine
Background: The research focused on the effects of pseudorabies virus on gene expression in piglet brain tissue. Objectives: The goal was to understand the changes in gene expression in piglet brains due to pseudorabies virus infection. Design: The study
Wei Sun, Shan-Shan Liu, Yu Fan, Sheng-Qing Deng, Hua-Qi Zhang, Fengzhao Zhu, Shi-He Long, Tao-Hua Ren, Ling Bai   +8 more
doaj   +1 more source

A gD&gC-substituted pseudorabies virus vaccine strain provides complete clinical protection and is helpful to prevent virus shedding against challenge by a Chinese pseudorabies variant

BMC Veterinary Research, 2019
Background Since 2011, pseudorabies caused by a variant PRV has re-emerged in many Chinese Bartha-K61-vaccinated pig farms. An efficacious vaccine is necessary to control this disease.
Chuanjian Zhang, Yamei Liu, Saisai Chen, Yongfeng Qiao, Mingpeng Guo, Yating Zheng, Mengwei Xu, Zhisheng Wang, Jibo Hou, Jichun Wang   +9 more
doaj   +1 more source

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1967-1975, July 2026.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann, Cecilie Klausen, Michael Karbiener, Thomas R. Kreil   +3 more
wiley   +1 more source