Results 71 to 80 of about 2,121 (171)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cannabis Use Among People Aged 65 and Older: Results From an Intercept Survey in New York City

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Cannabis use among older adults has increased in recent years. Age‐related physiological changes, socio‐ecological factors, and medications may exacerbate potential adverse effects of cannabis and complicate the detection of cannabis use disorder (CUD) in older adults.
Benjamin H. Han, Krish Jagasia, Tyler Simi, Nina Abukahok, Joseph J. Palamar   +4 more
wiley   +1 more source

Clinical pharmacokinetics of psilocin after psilocybin administration: a systematic review and post-hoc analysis [PDF]

Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin ...
Schoones, J.W., Jacobs, G.E., Esdonk, M.J. van, Heijden, K.V. van der, Otto, M.E., Borghans, L.G.J.M., Hasselt, J.G.C. van   +6 more
core   +1 more source

‘So many relationships in the room’: Participant perspectives on the affordances and challenges of co‐therapy in psychedelic assisted therapy

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Objectives Psychedelic‐assisted therapy (PAT) frequently utilises a “cotherapy” model, in which two therapists jointly support participants throughout dosing and psychotherapy sessions. While common in clinical trials, participant experiences of cotherapy remain underexplored.
Rachel Ham, John Gardner, Adrian Carter, Paul Liknaitzky   +3 more
wiley   +1 more source

Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats

Frontiers in Neuroscience
Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats.
Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris   +15 more
doaj   +1 more source

Living in the Mycelial World

Topics in Cognitive Science, EarlyView.
Abstract This manuscript documents a systematic ethnomycological analysis of ethnographic archives. Focusing on texts describing human–fungi interactions, I conduct a global, cross‐cultural review of mushroom use, covering 193 societies worldwide. The study reveals diverse mushroom‐related cultural practices, emphasizing the significance of fungi ...
Roope O. Kaaronen
wiley   +1 more source

A Quantitative Analysis of Street‐Level Drugs Seized in New South Wales, Australia: Purity, Dose and Adulterants

Drug and Alcohol Review, Volume 45, Issue 7, November 2026.
ABSTRACT Introduction The Combined Surveillance and Monitoring of Seized Samples (CoSMoSS) program is a joint harm reduction initiative between NSW Health and NSW Police Force. Here, we examine the contents and purity of a sample of seized suspected target drugs (cocaine, heroin, methamphetamine and 3,4‐methylenedioxymethamphetamine ‘MDMA’).
Janette L. Smith, Christine A. Harvey, NSW Police Force, Christopher J. Ewers, Kelsey E. Seyfang, Emily D. Bottero, Jared A. Brown, Thanjira Jiranantakan   +7 more
wiley   +1 more source

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

Addiction, Volume 121, Issue 10, Page 2822-2832, October 2026.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen, Irma S. van den Hengel‐Koot, Claudine C. Hunault, Dylan W. de Lange, Antoinette J. H. P. van Riel, Laura Hondebrink   +5 more
wiley   +1 more source

Effects of psilocin and psilocybin on human 5-HT4 serotonin receptors in atrial preparations of transgenic mice and humans [PDF]

Several fungi belonging to the genus Psilocybe, also called “magic mushrooms”, contain the hallucinogenic drugs psilocybin and psilocin. They are chemically related to serotonin (5-HT).
Azatsian, Karyna, Hofmann, Britt, Gergs, Ulrich, Dimov, Kiril, Neumann, Joachim   +4 more
core   +1 more source

Psilocybin and Chronic Neuropathic and Centralized Pain: Converging Mechanisms in Central Sensitization, Neuroplasticity, and Network Organization

Anesthesia Research
Background/Objectives: Neuropathic and chronic centralized pain disorders remain difficult to treat because they involve central sensitization, maladaptive neuroplasticity, neuroimmune activation, affective amplification, and large-scale network ...
Marina Seixas Studart e Neves, Camilla Teixeira Pinheiro Gusmão, Raimundo Chiyo, André Aloni João Manuel, Avelino Hemenegildo Ulundo, Irina Jacinto, Azeres Catumbela, Vladimir Carlos Casimiro João, Joel Armando Manuel, Capela António Pascoal, Carlos Victor Montefusco-Pereira, Howard Lopes Ribeiro Junior   +11 more
doaj   +1 more source