Results 1 to 10 of about 15,099 (199)

Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring [PDF]

Nature Communications
Psilocybin increases social connectedness and has strong clinical transdiagnostic efficacy for mental illness, making it a candidate treatment to reduce maternal disconnect, anxiety, and blunted affect seen in peripartum mood disorders.
Cassandra J. Hatzipantelis, Min Liu, Adam Love, Sadie J. Leventhal, Hero Maera, Srinidhi Viswanathan, Emily Avetisyan, Liana Belinsky, McKenna M. Rangel, Nina J. Jain, Max Kelly, Claire Copeland, Yara A. Khatib, Oliver Fiehn, David E. Olson, Danielle S. Stolzenberg   +15 more
doaj   +2 more sources

Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [PDF]

Scientific Reports, 2017
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood.
Robin Carhart-Harris, Leor Roseman, Lysia Demetriou   +2 more
exaly   +6 more sources

Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis [PDF]

Frontiers in Psychiatry
IntroductionThe subjective effects of psilocybin on obsessive-compulsive disorder (OCD) are under-explored. Therefore, we conducted a qualitative study of participant experiences from the first randomized placebo-controlled trial of single-dose ...
T. H. W. Ching, B. Stahnke, S. Shnayder, G. Agin-Liebes, T. G. Adams, L. Amoroso, O. Baiz, A. Belser, C. Bohner, M. Burke, E. D’Amico, G. DePalmer, J. Eilbott, G. Fram, R. Grazioplene, J. Hokanson, A. Jankovsky, S. A. Kichuk, B. Martins, P. Purohit, H. Schaer, Y. P. Sierra, C. Witherow, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, B. Kelmendi   +29 more
doaj   +2 more sources

Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatmentResearch in context [PDF]

EClinicalMedicine
Summary: Background: Post-traumatic stress disorder (PTSD) is a debilitating condition leading to significant personal and societal burden. Standard treatments frequently demonstrate limited efficacy, leading to persistent symptoms and high dropout ...
Nadav Liam Modlin, Victoria Williamson, Guy M. Goodwin, Ekaterina Malievskaia, Merve Atli, Zsofia Elek, Alice Gaillard, Don Koelpin, Anthony Cleare, Manish Agrawal, Rachel Yehuda, Namik Kirlic, James Rucker   +12 more
doaj   +2 more sources

Psilocybin desynchronizes the human brain

Nature
Abstract A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials 1–4 .
Benjamin Kay, Evan M Gordon, Timothy O Laumann   +2 more
exaly   +5 more sources

Cystathionine Gamma-Lyase Regulate Psilocybin Biosynthesis in Gymnopilus dilepis Mushroom via Amino Acid Metabolism Pathways

Journal of Fungi, 2022
As a potential medicine for the treatment of depression, psilocybin has gradually attracted attention. To elucidate the molecular mechanism regulating psilocybin synthesis in Gymnopilus dilepis, ultra-performance liquid chromatography (UPLC) was used to ...
Sen Yao, Chuanzheng Wei, Hui Lin, Peng Zhang, Yuanyuan Liu, Youjin Deng, Qianhui Huang, Baogui Xie   +7 more
doaj   +1 more source

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey

Frontiers in Psychiatry, 2023
IntroductionThe classic psychedelic psilocybin, found in some mushroom species, has received renewed interest in clinical research, showing potential mental health benefits in preliminary trials.
Sandeep M. Nayak, Sandeep M. Nayak, Hillary Jackson, Hillary Jackson, Nathan D. Sepeda, Nathan D. Sepeda, Nathan D. Sepeda, David S. Mathai, David S. Mathai, Sara So, Sara So, Abigail Yaffe, Abigail Yaffe, Hadi Zaki, Hadi Zaki, Trey J. Brasher, Matthew X. Lowe, Del R. P. Jolly, Frederick S. Barrett, Frederick S. Barrett, Frederick S. Barrett, Frederick S. Barrett, Roland R. Griffiths, Roland R. Griffiths, Roland R. Griffiths, Justin C. Strickland, Justin C. Strickland, Matthew W. Johnson, Heather Jackson, Albert Garcia-Romeu, Albert Garcia-Romeu   +30 more
doaj   +1 more source

Association of Psilocybin Use in Adolescents with Major Depressive Episode

European Psychiatry, 2022
Introduction Psilocybin is a psychedelic drug found in mushrooms, often referred to as magic mushrooms due to its visual and auditory hallucinations effects upon ingestion.
K. Shah, C. Trivedi, D. Kamrai, M. Akbar, W. Tankersley   +4 more
doaj   +1 more source

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

Scientific Reports, 2022
Psilocybin microdosing involves repeated self-administration of mushrooms containing psilocybin at doses small enough to not impact regular functioning. Microdose practices are diverse and include combining psilocybin with substances such as lion’s mane ...
Joseph M. Rootman, Maggie Kiraga, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers, Zach Walsh   +7 more
doaj   +1 more source

Psilocybin-Assisted Compassion Focused Therapy for Depression

Frontiers in Psychology, 2022
Psilocybin-assisted psychotherapy, i.e., psilocybin treatment with psychological support, has demonstrated the efficacy of psilocybin to reduce depressive symptoms.
Wendy Pots, Farid Chakhssi
doaj   +1 more source