Results 31 to 40 of about 21,032 (282)

Genome-wide determination of drug localization [PDF]

, 2014
A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins associated with the genome.
Anders, Lars, Bradner, James E., Fan, Zi Peng, Guenther, Matthew G., Lee, Tong Ihn, Lovén, Jakob, Marineau, Jason J., Qi, Jun, Rahl, Peter B., Sigova, Alla A., Smith, William B., Young, Richard A.   +11 more
core   +1 more source

Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines [PDF]

, 2012
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder
Campos, Ana M. F. Oliveira, Cerqueira, N. M. F. S. A., Francisco, Carla S., Rodrigues, L. R., Rodrigues, Lígia M.   +4 more
core   +1 more source

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. [PDF]

PLoS ONE, 2011
Interstrand crosslink (ICL)-inducing agents block the separation of the two DNA strands. They prevent transcription and replication and are used in clinics for the treatment of cancer and skin diseases. Here, we have introduced a single psoralen ICL at a
Cyrille Le Breton, Magali Hennion, Paola B Arimondo, Olivier Hyrien   +3 more
doaj   +1 more source

Effects of psoralen on the pharmacokinetics of anastrozole in rats

Pharmaceutical Biology, 2018
Context: Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. Objective: This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. Materials and
Yuzhu Zhang, Jingjing Wu, Yue Zhou, Yulian Yin, Hongfeng Chen   +4 more
doaj   +1 more source

The Immunogenicity and Properties of a Whole-Cell ETEC Vaccine Inactivated with Psoralen and UVA Light in Comparison to Formalin

Microorganisms, 2023
Inactivated whole-cell vaccines present a full repertoire of antigens to the immune system. Formalin treatment, a standard method for microbial inactivation, can modify or destroy protein antigenic epitopes.
Marlena M. Westcott, Maria Blevins, Thomas F. Wierzba, Alexis E. Morse, Kinnede R. White, Leigh Ann Sanders, John W. Sanders   +6 more
doaj   +1 more source

DNA-psoralen: single-molecule experiments and first principles calculations

, 2010
The authors measure the persistence and contour lengths of DNA-psoralen complexes, as a function of psoralen concentration, for intercalated and crosslinked complexes. In both cases, the persistence length monotonically increases until a certain critical
Alexandre, S. S., Lúcio, A. D., Mesquita, O. N., Nunes, R. W., Rocha, M. S.   +4 more
core   +1 more source

Induction of chromosome shattering by ultraviolet light and caffeine: The influence of different distributions of photolesions [PDF]

, 1986
Cells of synchonized and of asynchronously growing cultures of a V79 Chinese hamster line were microirradiated with a low poweer laser-UV-microbeam of wavelength 257 nm.
Barranco, Brenner, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, González-Fernández, Hens, Kihlman, Kihlman, Kihlman, Kihlman, Lau, Lehmann, Moreno, Nilsson, Painter, Painter, Raith, Rappold, Roberts, Schardin, Sedgwick, Setlow, Stack, Steward, Tatsumi, Tobey, Tomulin, Zorn, Zorn   +42 more
core   +1 more source

Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments

, 2015
In this review we focus on the idea of establishing connections between the mechanical properties of DNAligand complexes and the physical chemistry of DNA-ligand interactions.
Rocha, M. S.
core   +1 more source

A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver injury: a case study of Psoralea corylifolia Linn

Frontiers in Chemistry, 2023
Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immune status plays
Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Hui Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang   +41 more
doaj   +1 more source

Transition on the entropic elasticity of DNA induced by intercalating molecules

, 2007
We use optical tweezers to perform stretching experiments on DNA molecules when interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA molecule.
Ferreira, M. C., Mesquita, O. N., Rocha, M. S.   +2 more
core   +1 more source