Results 31 to 40 of about 18,448 (248)
In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies
Journal of Pharmacy and Bioallied Sciences, 2015 Introduction: Alzheimer′s disease (AD) has increased at an alarming rate and is now a worldwide health problem. Inhibitors of acetylcholinesterase (AChE) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for AD ...
Gauresh Somani +5 more
doaj +1 more source
Psoralen Derivatives with Enhanced Potency
Photochemistry and Photobiology, 2020 Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen’s clinical efficacy in several disease contexts, which
A. Buhimschi +8 more
semanticscholar +1 more source
A Case Report of Generalization of Localized Actinic Granuloma, an Unusual Diffuse Presentation Not Responding to Tofacitinib. [PDF]
Clin Case RepABSTRACT Actinic granuloma (AG), a rare and idiopathic skin condition primarily affecting middle‐aged and elderly individuals, is known for its persistent, asymptomatic annular plaques appearing on sun‐exposed areas. This report details the case of a 48‐year‐old diabetic male farmer with a rare presentation of generalized AG. The patient's lesions were
Al-Zahawi S, Ghanadan A, Saberi F.
europepmc +2 more sources
DETECTION OF HYDROPEROXIDES IN SOLUTIONS OF PHOTOOXIDIZED PSORALEN
Тонкие химические технологии, 2019 Photooxidized psoralen solutions possess a variety of biological effects, which implementation mechanism may presumably involve hydroperoxides. Here, the hydroperoxide content in photooxidized psoralen solutions was assessed using photometric FOX assay ...
V. V. Skarga +4 more
doaj +1 more source
ACS Omega, 2020 Psoralen is a furanocoumarin compound found in many herb medicines and is claimed to contribute to the hepatotoxicity caused by lots of traditional Chinese medicine.
Li Yang +5 more
semanticscholar +1 more source
PHOTOCHEMISTRY AND PHOTOBIOLOGY OF PSORALENS [PDF]
Photochemistry and Photobiology, 1979 Abstract— The photochemistry and photobiology of psoralens have been rcvicwed on the basis of selected literature. In addition to the well establishcd photoaddition of psoralens to DNA. photoreac‐tions involving RNA. tRNA and proteins warrant further studies.
Kenneth J. Tapley, Pill-Soon Song
openaire +3 more sources
Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. [PDF]
PLoS ONE, 2011 Interstrand crosslink (ICL)-inducing agents block the separation of the two DNA strands. They prevent transcription and replication and are used in clinics for the treatment of cancer and skin diseases. Here, we have introduced a single psoralen ICL at a
Cyrille Le Breton +3 more
doaj +1 more source
Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence
Applied Microbiology and BiotechnologyP seud omon as aeruginosa is a common opportunistic pathogen with growing resistance and presents heightened treatment challenges. Quorum sensing (QS) is a cell-to-cell communication system that contributes to the production of a variety of virulence ...
Fulong Wen +9 more
semanticscholar +1 more source
Psoralen: a narrative review of current and future therapeutic uses
Journal of Cancer Research and Clinical OncologyPsoralen is a family of naturally occurring photoactive compounds found in plants that acquire potential cytotoxicity when activated by specific frequencies of electromagnetic waves.
P. Galiatsatos +8 more
semanticscholar +1 more source
Frontiers in Chemistry, 2023 Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immune status plays
Ming-Liang Zhang +41 more
doaj +1 more source