Results 21 to 30 of about 18,017 (225)

Giant cell formation produced by laser microbeam irradiation of chromatin in Chinese hamster cells [PDF]

, 1981
A pulsed laser microbeam of wavelength 532 nm was used to produce visible small lesions in the nucleoplasm or in the cytoplasm of V79 Chinese hamster cells.
Altmann, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Burkhardt, Cain, Cremer, Cremer, Cremer, Cremer, Dreher, Factor, Geisinger, Hetzel, Kitzes, Leder, Leuchtenberger, Meredith, Moreno, Nakanishi, Peterson, Rattner, Schneider, Scott, Stevenson, Strahs, Tam, Tchakhotine, Wang   +34 more
core   +2 more sources

The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure [PDF]

, 2017
Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked ...
A Katafuchi, A Mazumder, AM Maxam, B Houten Van, BH Johnston, CG Neurauter, D Klein Douwel, DO Zharkov, DR Semlow, DT Long, GD Cimino, I Khutsishvili, IG Minko, J Huang, J Zhang, J Zhang, K Nojima, KR Kumaresan, L Wiederhold, LJ Niedernhofer, M Budzowska, M Liu, M Liu, M Liu, M Raschle, ML Dodson, ML Dronkert, ML Hegde, MR Hodskinson, PJ McHugh, PJ McHugh, RA Rieger, RP Cunningham, RS Cole, S Couve, S Couve-Privat, S Sharma, SZ Krokeide, TK Hazra, U Roy, V Bailly, V Bandaru, W Xu, X Shen, Z Yang   +44 more
core   +4 more sources

Psoralen induced cell cycle arrest by modulating Wnt/β-catenin pathway in breast cancer cells

Scientific Reports, 2018
Psoralen could inhibit the proliferation of human breast cancer cells, however, the molecular mechanism was unclear. We evaluated the anti-proliferative effects of psoralen by MTT, plate colony formation assay and cell cycle analysis in MCF-7 and MDA-MB ...
Xiaohong Wang, Chengfeng Xu, Yitong Hua, Kai Cheng, Yingzhe Zhang, Jian Liu, Yong Han, Song Liu, Guoqiang Zhang, Shujian Xu, Zhenlin Yang   +10 more
doaj   +1 more source

In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies

Journal of Pharmacy and Bioallied Sciences, 2015
Introduction: Alzheimer′s disease (AD) has increased at an alarming rate and is now a worldwide health problem. Inhibitors of acetylcholinesterase (AChE) leading to inhibition of acetylcholine breakdown constitute the main therapeutic strategy for AD ...
Gauresh Somani, Chinmay Kulkarni, Prashant Shinde, Rupesh Shelke, Kirti Laddha, Sadhana Sathaye   +5 more
doaj   +1 more source

In vitro demonstration of herbal exacerbation of paracetamol-induced hepatotoxicity

Phytomedicine Plus, 2022
Background: Paracetamol (acetaminophen) is one of the most accessible pharmaceutical analgesic and antipyretic agents. Similarly, traditional herbal medicines including Psoralea corylifolia, Astragalus propinquus and Atractylodes macrocephala have been ...
Susan M. Britza, Rachael Farrington, Roger W. Byard, Ian F. Musgrave   +3 more
doaj   +1 more source

Photodynamic Therapy of Necrobiosis Lipoidica - A Multicenter Study of 18 Patients [PDF]

, 2008
Background: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease.
Arenberger, P., Berking, C., Hegyi, J., Jemec, G. B. E., Ruzicka, Thomas   +4 more
core   +1 more source

Extracts and Metabolites against

Natural Product Communications, 2015
The biological activity of Ruta graveolens leaf tissue extracts obtained with different solvents (ethyl acetate, ethanol, and water) and metabolites (psoralen, 2-undecanone and rutin) against Spodoptera frugiperda was evaluated.
Benjamín A. Ayil-Gutiérrez, Jesús M. Villegas-Mendoza, Zuridai Santes-Hernández, Alma D. Paz-González, Maribel Mireles-Martínez, Ninfa M. Rosas-García, Gildardo Rivera   +6 more
doaj   +1 more source

Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells [PDF]

, 2017
Previous results link the mitochondrial potassium channel Kv1.3 (mitoKv1.3) to the regulation of apoptosis. By synthesizing new, mitochondria-targeted derivatives (PAPTP and PCARBTP) of PAP-1, a specific membrane-permeant Kv1.3 inhibitor, we have ...
Amigorena, Arcangeli, Beeton, Cahalan, Checchetto, Chittajallu, Cholo, Cidad, Comes, Connor, Deutsch, Diebold, Diwakarla, Doyle, Erdogan, Esteras, Fraser, Ghiani, Heginbotham, Hinz, Hu, Jang, Koren, Leanza, Leanza, Leanza, Lin, Long, Lu, Malinska, Manago, Nilius, Pardo, Peruzzo, Ralph, Ralph, Rauer, Shieh, Siegel, Szabo, Szabo, Tegla, Tonks, Urrego, Van Rensburg, Xu, Zaccagnino, Zhou, Zucca   +48 more
core   +2 more sources

Induction of chromosome shattering by ultraviolet light and caffeine: The influence of different distributions of photolesions [PDF]

, 1986
Cells of synchonized and of asynchronously growing cultures of a V79 Chinese hamster line were microirradiated with a low poweer laser-UV-microbeam of wavelength 257 nm.
Barranco, Brenner, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, González-Fernández, Hens, Kihlman, Kihlman, Kihlman, Kihlman, Lau, Lehmann, Moreno, Nilsson, Painter, Painter, Raith, Rappold, Roberts, Schardin, Sedgwick, Setlow, Stack, Steward, Tatsumi, Tobey, Tomulin, Zorn, Zorn   +42 more
core   +1 more source

DETECTION OF HYDROPEROXIDES IN SOLUTIONS OF PHOTOOXIDIZED PSORALEN

Тонкие химические технологии, 2019
Photooxidized psoralen solutions possess a variety of biological effects, which implementation mechanism may presumably involve hydroperoxides. Here, the hydroperoxide content in photooxidized psoralen solutions was assessed using photometric FOX assay ...
V. V. Skarga, E. V. Nevezhin, A. А. Matrosov, V. V. Negrebetsky, M. V. Malakhov   +4 more
doaj   +1 more source