Results 1 to 10 of about 1,995 (182)

Methoxsalen deteriorative effects on the testicular parenchyma and testosterone synthesis gene expression in male rats [PDF]

Scientific Reports
Studies show that psoralens have adverse effects on the reproductive system. This study investigated the impact of methoxsalen in combination with UVA on testicular parenchyma and the expression level of testosterone synthesis pathway genes as well as ...
Zahra Gholipour, Abbas Fazlinia, Farhad Koohpeyma, Hediye Fahandezh Saadi, Mesbah Shams, Sanaz Dastghaib   +5 more
doaj   +3 more sources

Clinical and dermoscopic assessment of the efficacy of topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo [PDF]

Scientific Reports
Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the study was to assess clinically and dermoscopically the efficacy of topical trichloroacetic acid 70%
Ahmed R. Elshahed, Amr M. Ammar, Abdallah M. Ali, Mohamed L. Elsaie   +3 more
doaj   +3 more sources

Methoxsalen-induced macular toxicity

Indian Journal of Ophthalmology, 2017
Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as ...
Aditya Maitray, Pukhraj Rishi
doaj   +3 more sources

Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats

Molecules, 2020
Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced ...
Ju Ri Ham, Ra-Yeong Choi, Hae-In Lee, Mi-Kyung Lee   +3 more
doaj   +3 more sources

Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice

International Journal of Molecular Sciences, 2019
This study evaluated whether bergapten and methoxsalen could prevent diabetes-induced osteoporosis and its underlying mechanism. For 10 weeks, bergapten or methoxsalen (0.02%, w/w) was applied to diabetic mice that were provided with a high-fat diet and ...
Ju Ri Ham, Mi-Kyung Lee, Hae-In Lee
exaly   +3 more sources

A randomized phase II study of SM‐88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond [PDF]

Cancer Medicine, 2022
Background This trial explores SM‐88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) Methods Forty‐nine patients were randomized to daily 460 or 920 mg oral SM‐88 with MPS (SM‐88 ...
Marcus S. Noel, Semmie Kim, Marion L. Hartley, Steve Wong, Vincent J. Picozzi, Harry Staszewski, Dae Won Kim, Jan M. Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J. Ocean, Andrea Wang‐Gillam   +11 more
doaj   +3 more sources

Dermoscopic Evaluation of the Efficacy of Topical Trichloroacetic acid 70% Versus Methoxsalen 0.2 % Paint in Acral Vitiligo, A comparative Cross-Sectional Study [PDF]

Al-Azhar International Medical Journal
Background: Vitiligo, an acquired disorder characterized by depigmentation, has an unidentified etiology. The pathogenesis of this condition has been the subject of various hypotheses, such as autoimmune, neurohumoral, and autocytotoxic theories.Aim and ...
A. EL-Shahid, A. A. Ammar, A. M. Ali
doaj   +3 more sources

Novel inactivation of the causative fungal pathogen of white-nose syndrome with methoxsalen plus ultraviolet A or B radiation.

PLoS ONE, 2020
White-nose syndrome is a fungal disease responsible for the rapid decline of North American bat populations. This study addressed a novel method for inactivating Pseudogymnoascus destructans, the causative agent of WNS, using ultraviolet A (UVA) or B ...
Colin J Hartman, Joseph C Mester, Patrick M Hare, Alan I Cohen   +3 more
doaj   +4 more sources

Protective Effect of Methoxsalen on Spinal Cord Injury in the Rat Model via Regulation of the PI3K/Akt Pathway. [PDF]

Iran J Pharm Res
Background Spinal cord injury (SCI) is a major cause of disability, and the management of secondary injury remains challenging. Objectives This study evaluated the protective effects of methoxsalen against SCI and investigated its potential mechanism of ...
Zhaohu M, Zheng Z, Qunqun S.
europepmc   +2 more sources

Methoxsalen Inhibits the Acquisition of Nicotine Self-Administration: Attenuation by Cotinine Replacement in Male Rats. [PDF]

Nicotine Tob Res
INTRODUCTION Cigarette smoking remains the leading preventable cause of disease and death. Nicotine is the primary reinforcing ingredient in cigarettes sustaining addiction.
Ding ZM, Neslund EM, Sun D, Tan X.
europepmc   +2 more sources