Results 21 to 30 of about 1,011 (137)

Single-Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions. [PDF]

JOR Spine
IVDD has various NPC subgroups, including HT‐CLNP, fibrous NPC, sticky NPC, regulatory NPC, and steady‐state NPC. Furthermore, numerous immune cell infiltrates, particularly monocytes and macrophages, play a crucial role in the evolution of IVDD. Parthenogenesis' key components are Osthole, Columbianadin, and Bergapten, which absorb IVDD by managing ...
Song C, Wu X, Chen C, Shen B, Mei Y, Yan Q, Jiang F, Chen F, Liu F.   +8 more
europepmc   +2 more sources

A randomized phase II study of SM‐88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond

Cancer Medicine, 2022
Background This trial explores SM‐88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) Methods Forty‐nine patients were randomized to daily 460 or 920 mg oral SM‐88 with MPS (SM‐88 ...
Marcus S. Noel, Semmie Kim, Marion L. Hartley, Steve Wong, Vincent J. Picozzi, Harry Staszewski, Dae Won Kim, Jan M. Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J. Ocean, Andrea Wang‐Gillam   +11 more
doaj   +1 more source

The Adverse Effects of Methoxsalen on The Oogenesis of Balb/C Mice [PDF]

Cell Journal, 2013
Objective: Methoxsalen is a natural photoactive compound which is found in many seed plants. A number of epidermal proliferative disorders can be treated by methoxsalen along with long wave ultraviolet A (UVA).Materials and Methods: In an experimental ...
Abbas Shockravi, Homa Mohseni Kouchesfahani, Esmaeil Fattahi, Mona Farhadi, Kazem Parivar   +4 more
doaj  

Novel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells

Scientific Reports, 2022
Psoralen derivatives are well known for their unique phototoxicity and also exhibits promising anti-breast cancer activity both in the presence and the absence of UVA irradiation.
Chiphada Aekrungrueangkit, Sirilak Wangngae, Anyanee Kamkaew, Ruchuta Ardkhean, Sanit Thongnest, Jutatip Boonsombat, Somsak Ruchirawat, Tanatorn Khotavivattana   +7 more
doaj   +1 more source

FOTOFÉRESE EXTRACORPÓREA – PRIMEIRO PROCEDIMENTO REALIZADO NO SERVIÇO DE AFÉRESE DO BANCO DE SANGUE DO HOSPITAL SANTA MARCELINA – RELATO DE CASO

Hematology, Transfusion and Cell Therapy, 2021
Introdução: Fotoférese Extracorpórea (FEC) se baseia na manipulação dos linfócitos T com substâncias fotossensibilizantes que quando expostos à luz ultravioleta (UV) sofrem apoptose e ao serem devolvidos ao paciente desencadeiam uma série de efeitos ...
ST Alves, AKM Bessa, LMDSR Araujo, LS Nepomuceno, RD Santos, JSR Oliveira   +5 more
doaj   +1 more source

Dermoscopic Evaluation of the Efficacy of Topical Trichloroacetic acid 70% Versus Methoxsalen 0.2 % Paint in Acral Vitiligo, A comparative Cross-Sectional Study [PDF]

Al-Azhar International Medical Journal
Background: Vitiligo, an acquired disorder characterized by depigmentation, has an unidentified etiology. The pathogenesis of this condition has been the subject of various hypotheses, such as autoimmune, neurohumoral, and autocytotoxic theories.Aim and ...
doaj   +1 more source

Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study

Pediatric Dermatology, EarlyView.
ABSTRACT Although topical corticosteroids are known triggers in the development of perioral dermatitis (PD), investigation into inhalant and nasal corticosteroid preparations, commonly used to manage allergic rhinitis and asthma, remains limited to case series.
Taylor Merkle, Caitlyn Curley, Dylan Wambold, Basira Iginla, Erum N. Ilyas   +4 more
wiley   +1 more source

Venous and arterial thrombosis following extracorporeal photopheresis: A descriptive cohort study using a federated electronic health record network

Transfusion, EarlyView.
Abstract Background In 2018, the FDA reported VTE events in patients undergoing ECP, but these reports lacked a population‐level denominator to contextualize the risk against the known baseline thrombotic burden of the underlying conditions. Study Design and Methods We conducted a descriptive retrospective cohort study using the TriNetX federated EHR ...
Caitlin Raymond
wiley   +1 more source

Nodular Scleroderma in a Patient With Anti–RNA Polymerase III–Antibody Positive Systemic Sclerosis: A Case Report and Literature Review

The Journal of Dermatology, Volume 53, Issue 8, Page 1213-1216, August 2026.
ABSTRACT Nodular scleroderma (NS) is a rare manifestation of systemic sclerosis (SSc) that can clinically resemble keloids, often leading to diagnostic difficulty. Herein we report a case of a 76‐year‐old woman with anti–RNA polymerase III antibody–positive SSc who developed progressive erythematous, pruritic, keloid‐like plaques 3 months after ...
Kyoko Kanno, Yuki Kobayashi, Yasuyuki Fujita   +2 more
wiley   +1 more source

Electrochemical Three‐Component Synthesis of Heteroaryl Sulfonates

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
An electrochemical, metal‐free three‐component strategy for direct C(sp2)─H sulfonation of electron‐rich heteroarenes using SO2 and alcohols is described. Utilizing inexpensive graphite electrodes and practical SO2 stock solutions under mild conditions, this method provides straightforward access to heteroaryl sulfonates from simple building blocks ...
Po‐Chung Chien, Harald Kelm, Georg Manolikakes   +2 more
wiley   +1 more source