Results 11 to 20 of about 2,064 (176)

Methoxsalen

Reactions Weekly, 2006
europepmc   +4 more sources

Dehydrocostus Lactone Inhibits Microglia-Mediated Neuroinflammation by Targeting CYP2A6 to Improve Ischemic Brain Injury. [PDF]

CNS Neurosci Ther
Dehydrocostus lactone (DHC) inhibits microglia‐mediated neuroinflammation by targeting CYP2A6, reducing the release of pro‐inflammatory factors and improving nerve function impairment, thereby alleviating ischemic brain injury. ABSTRACT Background Neuroinflammation is an important factor in ischemic stroke.
Shu X, Zou X, Zhang J, Fang X, Wang X, Wu H, He X, Sha D.   +7 more
europepmc   +2 more sources

Novel inactivation of the causative fungal pathogen of white-nose syndrome with methoxsalen plus ultraviolet A or B radiation.

PLoS ONE, 2020
White-nose syndrome is a fungal disease responsible for the rapid decline of North American bat populations. This study addressed a novel method for inactivating Pseudogymnoascus destructans, the causative agent of WNS, using ultraviolet A (UVA) or B ...
Colin J Hartman, Joseph C Mester, Patrick M Hare, Alan I Cohen   +3 more
doaj   +2 more sources

Suppressive CD8+ T-Cells Are Key Cellular Mediators of Extracorporeal Photopheresis. [PDF]

J Clin Apher
ABSTRACT Extracorporeal photopheresis (ECP) is a widely utilized immunomodulatory procedure with an incompletely defined mechanism. In graft‐versus‐host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T‐cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell–mediated ...
Rogers KJ, Eschbacher KL, Zacharias Z, Kale K, Crawford MP, Knudson CM, Boyden AW, Karandikar NJ.   +7 more
europepmc   +2 more sources

EDA Complex-Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP. [PDF]

Angew Chem Int Ed Engl
In this work, we report a novel light‐mediated desaturation strategy enabled by electron donor–acceptor complex formation. DFT and mechanistic studies reveal that the reaction proceeds via single‐electron transfer, hydrogen atom transfer, and base‐mediated deprotonation sequentially with pyridinium salt serving dually as oxidant and base, and ...
Maiti R, Cauwenbergh R, Nath A, Guimarães ABR, Qin Y, Maseras F, Das S.   +6 more
europepmc   +3 more sources

Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats

Molecules, 2020
Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced ...
Ju Ri Ham, Ra-Yeong Choi, Hae-In Lee, Mi-Kyung Lee   +3 more
doaj   +1 more source

Single-Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions. [PDF]

JOR Spine
IVDD has various NPC subgroups, including HT‐CLNP, fibrous NPC, sticky NPC, regulatory NPC, and steady‐state NPC. Furthermore, numerous immune cell infiltrates, particularly monocytes and macrophages, play a crucial role in the evolution of IVDD. Parthenogenesis' key components are Osthole, Columbianadin, and Bergapten, which absorb IVDD by managing ...
Song C, Wu X, Chen C, Shen B, Mei Y, Yan Q, Jiang F, Chen F, Liu F.   +8 more
europepmc   +2 more sources

Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. [PDF]

, 2020
Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices ...
A Ashoor, A Kuryatov, A Loukola, A Loukola, A Markou, A Pandhare, AA George, AA Strasser, AB Tekinay, AC Harris, AC Villanti, AJ Lanca, AJ Law, AK Stoker, AR Tapper, AT Peana, B Forget, B Froeliger, B Le Foll, B Lenz, BJ Hall, BJ Henderson, CD Fowler, CD Fowler, CDC, CJ Livingston, CL Walters, CL Walters, CM Flores, D Bagdas, D Carmelli, D Gonzales, D Ji, D John, D Vullhorst, DB Vazquez-Sanroman, DC Perry, DK Williams, E Wada, EC Pittaras, ED Claus, EE DeVito, EJ Nestler, EN Lyukmanova, FI Carroll, FJ McClernon, G Di Chiara, G Kong, G Schoenbaum, GS Portugal, H Xian, HD Mansvelder, I Ibanez-Tallon, J Hartmann-Boyce, J Hartmann-Boyce, J Ramirez-Latorre, J Tang, JA Dani, JA Dani, JA Hill Jr, JA Wilking, JE Lisman, JJ Couey, JM Miwa, JM Miwa, JM Miwa, JM Williams, JP Changeux, JR Turner, JR Turner, JR Turner, JS Fowler, JS Fowler, JW Kenney, JZ Liu, KA Garrison, KJ Clemens, KJ Jackson, KJ Jackson, KJ Jackson, KJ Jackson, KP Cosgrove, KS Kendler, KS Okuyemi, L Lagostena, L Zhou, LJ Bierut, LM Tuesta, LP Dwoskin, LP Dwoskin, M Alkondon, M Alkondon, M Arvaniti, M De Biasi, M Foddai, M Kallupi, M Kassiou, M Yuan, M Zhang, MD Li, MI Damaj, MJ Marks, MJ Orejarena, ML Fisher, ML Goniewicz, MP Demars, MR Picciotto, MS Thomsen, MT Bardo, N Champtiaux, N Omelchenko, NI Nissen, NL Benowitz, NL Saccone, O Salminen, P Fagan, P Li, P Truman, PF Sullivan, PJ Welsby, R Girod, R Klink, R Miech, R Salas, R Srinivasan, RL Ashare, RS Caraballo, S Dodd, S Jones, S Kuhn, S Nakauchi, S Pons, S Tonstad, SD Alsharari, SD Alsharari, SS Sanjakdar, TT Smith, U Broms, U Maskos, V Gerzanich, W Berrettini, WA Corrigall, WD Myers, X Pang, Y Li, YY Huang, Z Jin   +146 more
core   +1 more source

New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity: Synthesis, Molecular Docking, and Physiochemical Characterization

Frontiers in Chemistry, 2022
In this work, we synthesize the sulfonated Schiff bases of the chitosan derivatives 2a-2j without the use of a catalyst in two moderately straightforward steps with good yield within a short reaction time.
Ponnusamy Packialakshmi, Perumal Gobinath, Daoud Ali, Saud Alarifi, Raman Gurusamy, Akbar Idhayadhulla, Radhakrishnan Surendrakumar   +6 more
doaj   +1 more source

A Study of the Furocoumarin Derivative of Ruta Chalepensis L. (Rutaceae)

Iraqi Journal of Pharmaceutical Sciences, 2017
The content of Furocoumarin derivatives (Psoralens) of Ruta Chalepensis L. (Whole plant) was studied by simple extraction with petroleum ether (b.p. 60-80Co).
Ekbal H.AL-Khateeb, Ali A. AL-Shamma, Bajes A. Nehar   +2 more
doaj   +3 more sources