Results 1 to 10 of about 18,017 (225)

Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder

Frontiers in Pharmacology, 2018
Psoralen toxicity is an issue of wide concern. However, an assay for psoralen-induced developmental toxicity has not been reported to date. Moreover, the underlying mechanism of psoralen-induced developmental toxicity is unclear.
Qing Xia, Yun Zhang, Haotian Kong
exaly   +3 more sources

A Review of the Pharmacological Properties of Psoralen

Frontiers in Pharmacology, 2020
Psoralen is the principal bioactive component in the dried fruits of Cullen corylifolium (L.) Medik (syn. Psoralea corylifolia L), termed “Buguzhi” in traditional Chinese medicine (TCM).
Xiaominting Song, Lu Tan, Miao Wang
exaly   +3 more sources

Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

Frontiers in Pharmacology, 2018
Psoralen is a major component of the common traditional Chinese medicine Fructus Psoraleae (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and the underlying mechanisms.
Wang Zhou, Xi Chen, Guolin Zhao, Dengqiu Xu, Zhenzhou Jiang, Zhenzhou Jiang, Zhenzhou Jiang, Luyong Zhang, Luyong Zhang, Luyong Zhang, Luyong Zhang, Tao Wang, Tao Wang   +12 more
exaly   +3 more sources

New Application of Psoralen and Angelicin on Periodontitis With Anti-bacterial, Anti-inflammatory, and Osteogenesis Effects

Frontiers in Cellular and Infection Microbiology, 2018
Psoralen and angelicin are two effective compounds isolated from psoraleae, a traditional Chinese medicine. They have a wide range of applications for bone disease treatment and immune modulation. In this study, we explored their new applications for the
Yi Hu, Yue Liao, Huiwen Chen
exaly   +3 more sources

Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides [PDF]

Communications Chemistry
Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA.
Yu Mikame, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi   +4 more
doaj   +2 more sources

Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells

Cells, 2022
Non-alcoholic fatty liver disease (NAFLD) held a high global prevalence in recent decades. Hepatic lipid deposition is the major characteristic of NAFLD. We aim to explore the mechanisms of psoralen on lipid deposition in NAFLD.
Yuhao Wang, Yonglun Wang, Fang Li, Jie Zou, Xiaoqian Li, Mengxia Xu, Daojiang Yu, Yijia Ma, Wei Huang, Xiaodong Sun, Yuanyuan Zhang   +10 more
doaj   +1 more source

Psoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Psoralen is a main active component of Psoralea corylifolia Linn. (Leguminosae). Psoralen has been reported to show antitumor effects and activity to accelerate osteoblastic proliferation.
Shubo Li, Hongqin Tu
doaj   +1 more source

Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (
Xin-Feng Lin, Qi-Long Jiang, Zhi-Long Peng, Yi-Le Ning, Yuan-Yuan Luo, Fu Zhao, Xian Peng, Wei-Tao Chen   +7 more
doaj   +1 more source

Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

Scientific Reports, 2021
Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the ...
Huxiao Li, Jianrong Xu, Xiaotian Li, Yi Hu, Yue Liao, Wei Zhou, Zhongchen Song   +6 more
doaj   +1 more source

Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874

BMC Pharmacology and Toxicology, 2020
Background Diabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient of Psoralea corylifolia Linn.
Yongtao Lin, Lili Zhong, Hailun Li, Yong Xu, Xiang Li, Donghui Zheng   +5 more
doaj   +1 more source