Results 41 to 50 of about 18,367 (247)

Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay

Molecules, 2017
Psoralen and isopsoralen are secondary plant metabolites found in many fruits, vegetables, and medicinal herbs. Psoralen-containing plants (Psoralea corylifolia L.) have been reported to cause hepatotoxicity.
Yue Hai, Shan Feng, Lili Wang, Yetao Ma, Yiran Zhai, Zijun Wu, Sichao Zhang, Xin He   +7 more
doaj   +1 more source

Combinations of Blue and Red LEDs Increase the Morphophysiological Performance and Furanocoumarin Production of Brosimum gaudichaudii Trécul in vitro

Frontiers in Plant Science, 2021
Brosimum gaudichaudii is a plant species with medicinal relevance due to its furanocoumarin accumulation. The accumulation of these compounds in the root promotes predatory extractivism, which threatens the conservation of the species.
Érica Letícia Gomes Costa, Fernanda dos Santos Farnese, Thales Caetano de Oliveira, Márcio Rosa, Arthur Almeida Rodrigues, Erika Crispim Resende, Ana Helena Januario, Fabiano Guimarães Silva   +7 more
doaj   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent

ChemMedChem, Accepted Article.
A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama, Akira Toriba, Atsushi Shibata, Takehiko Wada, Asako Yamayoshi, Yu Mikame   +5 more
wiley   +1 more source

Expanding the Horizons of Phototherapy: A Review on the Superior Performance of Chalcogen‐Based Photosensitizers and Photothermal Agents for Cancer Therapy

ChemPhotoChem, EarlyView.
This review summarizes recent progress in chalcogen (S, Se, Te)‐incorporated photosensitizers and photothermal agent design. It explores synthetic strategies, spectroscopic and computational characterization, and in vitro/in vivo evaluations, showcasing the potential of these compounds for photodynamic and photothermal therapies.
Subhrakant Jena, Pranay Mohanty, Laxmipriya Dash, Himansu S. Biswal   +3 more
wiley   +1 more source

Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens

Journal of Nucleic Acids, 2010
Triplex-forming oligonucleotides (TFOs) with both DNA and 2′-O-methyl RNA backbones can direct psoralen photoadducts to specific DNA sequences. However, the functional consequences of these differing structures on psoralen photoreactivity are unknown. We
Rajagopal Krishnan, Dennis H. Oh
doaj   +1 more source

The Association of Psoriasis With Sleep Disorders in a Diverse National Cohort

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Higher prevalence of sleep disorders is seen in persons with psoriasis (PsO). However, the extent to which sleep conditions are linked to PsO severity, particularly across diverse populations, remains unknown. Bridging this knowledge gap is vital for developing comprehensive, equitable and personalized care strategies. Objectives We
Michael J. Diaz, Zaim Haq, Jasmine T. Tran, Parsa Abdi, Nicole Natarelli, Wilson Liao, Marjorie E. Montanez‐Wiscovich   +6 more
wiley   +1 more source

Formulation and evaluation of antipsoriatic gel using natural excipients

Journal of Acute Disease, 2013
Objective: To develop topical gel formulations of Psoralen using natural excipients to minimize the side effects of synthetic drugs. Methods: The Psoralen gel formulations were prepared using different natural gums and polymers.
Raghupatruni Jhansi Laxmi, R. Karthikeyan, P. Srinivasa Babu, R.V.V. Narendra Babu   +3 more
doaj   +1 more source

Evaluation of S100B serum level as a biomarker of disease activity in vitiligo patients [PDF]

International Journal of Medical Arts, 2019
Background: Vitiligo is a depigmenting disorder characterized by the appearance of circumscribed white macules in the skin. The aetiology of vitiligo is not clear, and although various hypotheses have been proposed.
radwa abd El-Halim, Hasan Mohamed, Ibrahim Fouda, Hesham Abd El-Samee   +3 more
doaj   +1 more source

Mycosis Fungoides in Paediatric Patients: A Real‐Life Retrospective Study

JEADV Clinical Practice, EarlyView.
Our study represents the largest cohort of children with MF worldwide, providing relevant evidence supporting phototherapy as first‐line treatment, with an overall remission rate of 36.36%. Both topical and systemic therapy also showed favourable outcomes.
Mariana de la Vega, María Antonieta Domínguez Gómez, Martha Alejandra Morales‐Sánchez   +2 more
wiley   +1 more source