Improvement in Solubility–Permeability Interplay of Psoralens from Brosimum gaudichaudii Plant Extract upon Complexation with Hydroxypropyl-β-cyclodextrin [PDF]
Molecules, 2022 Psoralen (PSO) and 5-methoxypsoralen (5-MOP) are widely used drugs in oral photochemotherapy against vitiligo and major bioactive components of root bark extract of Brosimum gaudichaudii Trécul (EBGT), previously standardized by LC-MS.
Rúbia Darc Machado +8 more
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New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants [PDF]
LifeThe present review explores the underlying mechanisms of phytophotodermatitis, a non-immunologic skin reaction triggered by certain plants followed by exposure to ultraviolet radiation emitted by sunlight.
Cristina Grosu (Dumitrescu) +8 more
doaj +2 more sources
RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity [PDF]
mSphere, 2023 Pathogen inactivation is a strategy to improve the safety of transfusion products. The only pathogen reduction technology for blood products currently approved in the US utilizes a psoralen compound, called amotosalen, in combination with UVA light to ...
Alex B. Green +10 more
doaj +2 more sources
The role of phototherapy in pediatric dermatology [PDF]
Anais Brasileiros de DermatologiaBackground Phototherapy is one of the widely used therapeutic options in dermatology, and it has proven effective for many dermatological conditions.
Eine Benavides +3 more
doaj +3 more sources
Preliminary Safety Assessment for Mandarin Orange Peel Administration to Dogs Based on Physical Conditions and Blood Examination Parameters [PDF]
MetabolitesBackground/Objectives: Mandarin orange peel (MOP) is rich in bioactive polymethoxyflavones, including hesperidin and nobiletin, which have shown neuroprotective effects in rodent models.
Tomohiro Yonezawa +6 more
doaj +2 more sources
Pathogens, 2022 The handling of highly pathogenic viruses, whether for diagnostic or research purposes, often requires an inactivation step. This article reviews available inactivation techniques published in peer-reviewed journals and their benefits and limitations in ...
Simon Elveborg +2 more
doaj +1 more source
Tracing the Photoaddition of Pharmaceutical Psoralens to DNA
Molecules, 2020 The psoralens 8-methoxypsoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) and 5-methoxypsoralen (5-MOP) find clinical application in PUVA (psoralen + UVA) therapy. PUVA treats skin diseases like psoriasis and atopic eczema.
Janina Diekmann +3 more
doaj +1 more source
Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome
Molecules, 2020 Protein degradation is a fundamental process in all living organisms. An important part of this system is a multisubunit, barrel-shaped protease complex called the proteasome.
Kaja Rožman +6 more
doaj +1 more source
Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?
Antibiotics, 2020 Since the early work of the 1900s it has been axiomatic that photodynamic action requires the presence of sufficient ambient oxygen. The Type I photochemical pathway involves electron transfer reactions leading to the production of reactive oxygen ...
Michael R Hamblin, Heidi Abrahamse
doaj +1 more source
Pigments’ analysis of Citrus juicing making by‐products by LC‐MS/MS and LC‐DAD
MethodsX, 2022 Citrus fruits Cold Press Essential Oils (CPEOs) constitute a low-cost by-product produced during the juice making process that are composed by a volatile and a non-volatile fraction. Their non-volatile fractions are rich in valuable secondary metabolites,
Eleni D. Myrtsi +3 more
doaj +1 more source