Results 91 to 100 of about 272,684 (347)

Arginine Metabolic Disruption Impairs Hair Regeneration via ROS‐Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia

Advanced Science, EarlyView.
Arginine deficiency accelerates androgenetic alopecia. Serum metabolome shows reduced circulating arginine, while local metabolic disruption depletes follicular reserves, triggering reactive oxygen species (ROS) accumulation and mTOR suppression that induce hair miniaturization.
Shixin Duan, Guo Li, Yanji Chu, Junbo Zhang, Li Yang, Yujin Zhang, Fangfen Liu, Jiayun Li, Mengting Chen, Ben Wang, Zhixiang Zhao, Wei Shi, Yiya Zhang, Guangtong Deng, Xinwei Kuang, Hongfu Xie, Yufan Cheng, Zhili Deng, Ji Li, Yan Tang   +19 more
wiley   +1 more source

Microbe-host interplay in atopic dermatitis and psoriasis

Nature Communications, 2019
Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood.
N. Fyhrquist, Gareth Muirhead, S. Prast-Nielsen, M. Jeanmougin, P. Oláh, T. Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, H. Sinkko, E. H. van den Bogaard, P. Zeeuwen, G. Rikken, J. Schalkwijk, H. Niehues, W. Däubener, S. Eller, H. Alexander, D. Pennino, S. Suomela, Ioannis Tessas, E. Lybeck, A. Baran, H. Darban, R. S. Gangwar, U. Gerstel, Katharina Jahn, Piia Karisola, L. Yan, B. Hansmann, S. Katayama, S. Meller, M. Bylesjö, P. Hupé, F. Levi‐Schaffer, Dario Greco, A. Ranki, J. Schröder, J. Barker, J. Kere, S. Tsoka, A. Lauerma, V. Soumelis, F. Nestle, B. Homey, B. Andersson, H. Alenius   +46 more
semanticscholar   +1 more source

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Advances in Therapy, 2020
Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular ...
W. Masson, M. Lobo, G. Molinero
semanticscholar   +1 more source

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source

Botulinum Toxin A in Treatment of Facial Flushing

Acta Medica Iranica, 2016
Flushing is a condition with episodic attacks of redness of the skin with a sensation of warmth or burning, this disease causes emotional and functional problems in patients.
Gholamreza Eshghi, Leila Khezrian, Pedram Alirezaei   +2 more
doaj  

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

A Direct and Practical Approach to Assessing the Impact of Emulsion Composition on Vitamin A Stability

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Vitamin A is an essential micronutrient involved in vision, immunity, and growth. Despite its widespread use in food, cosmetic, and pharmaceutical products, vitamin A is highly prone to oxidation due to its conjugated double bonds, leading to reduced biological activity and efficacy.
M. De Vreese, E. Durand, B. Baréa, D. Morvan, C. Aleman, J. Lecomte, P. Villeneuve   +6 more
wiley   +1 more source

Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis

Cells, 2019
Located at the skin surface, keratinocytes (KCs) are constantly exposed to external stimuli and are the first responders to invading pathogens and injury.
Xiaowei Zhang, Meimei Yin, Ling-juan Zhang   +2 more
semanticscholar   +1 more source

Association between systemic immune inflammation index, systemic inflammation response index and adult psoriasis: evidence from NHANES

Frontiers in Immunology
BackgroundThe systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are both novel biomarkers and predictors of inflammation. Psoriasis is a skin disease characterized by chronic inflammation.
Rui Ma, Rui Ma, Lian Cui, Lian Cui, Jiangluyi Cai, Jiangluyi Cai, Nan Yang, Nan Yang, Yuanyuan Wang, Yuanyuan Wang, Qianyu Chen, Qianyu Chen, Wenjuan Chen, Wenjuan Chen, Chen Peng, Chen Peng, Hui Qin, Hui Qin, Yangfeng Ding, Yangfeng Ding, Xin Wang, Xin Wang, Qian Yu, Qian Yu, Yuling Shi, Yuling Shi   +25 more
doaj   +1 more source

Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis.

New England Journal of Medicine, 2019
Interleukin-36 Blockade in Pustular Psoriasis Seven patients with pustular psoriasis, three with mutations in IL36RN, were treated with a monoclonal antibody against interleukin-36 receptor and had...
H. Bachelez, S. Choon, S. Marrakchi, A. Burden, T. Tsai, A. Morita, H. Turki, D. Hall, Michael Shear, P. Baum, S. Padula, C. Thoma   +11 more
semanticscholar   +1 more source