Results 101 to 110 of about 166,859 (297)
Human Fibroblast‐Myeloid cell tissue atlas across lung, synovium, skin and heart
Arthritis &Rheumatology, Accepted Article.Background The availability of single‐cell RNA sequencing (scRNAseq data) in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald +9 more
wiley +1 more source
From Interferon Signature to the Clinical Landscape: Type I Interferonopathies
Arthritis &Rheumatology, Accepted Article.Background Type I interferonopathies are heterogeneous diseases driven by dysregulated IFN‐I signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. Objective To characterize the clinical, immunological, genetic, molecular profiles of patients with suspected enhanced IFN‐I signaling, and assess ...
Ismail Yaz +13 more
wiley +1 more source
Differential Diagnosis for Nail Psoriasis
, 2014 Nail involvement occurs in up to 50 % of patients with psoriasis. Although most patients experience concurrent skin involvement, 1–5 % of patients present with nail changes alone. In these patients, it can be diagnostically challenging, as psoriatic nail
Antonella Tosti +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley +3 more
wiley +1 more source
“Psoriasis, factor de riesgo para desarrollar enfermedades cardiovasculares y síndrome metabólico”
, 2017 La psoriasis es una enfermedad crónica inflamatoria común que se caracteriza por la presencia de placas eritematosas de bordes definidos con placas plateadas. Tiene un carácter multifactorial y se relaciona con varias enfermedades.
Ponce Torres, Christian David
core +1 more source
Frontiers in ImmunologyBackgroundPsoriasis severity and symptoms are widely known to vary seasonally. However, evidence on the impact of seasonality on treatment outcomes is limited, with vague season definitions.
Xinyi Song, Qin Yang, Yuye Wang, Ning Yu
doaj +1 more source
A psoriasis immunterápiás lehetőségei
, 2020 A psoriasis a világ teljes népességének 2-3%-át, míg Magyarországon közel 150-200.000 főt érint. Ez az autoimmun eredetű, krónikus lefolyású bőrbetegség leggyakrabban pikkelyes, hámló, vörös foltokkal, fájdalommal és viszketéssel jár együtt.
Kiss, Edina
core
Lost and found in translation: the value of the human imiquimod model
British Journal of Clinical Pharmacology, EarlyView.Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs +6 more
wiley +1 more source
Biopharmaceutics &Drug Disposition, EarlyView.This study identified new optimal allometric scaling exponents for human PK prediction of monoclonal antibodies with linear PKs from marmoset PK data. In addition, immunogenicity in common marmosets was evaluated following the repeated dose of golimumab and ustekinumab, minimal anti‐drug antibodies were detected.
Ayaka Tajiri +6 more
wiley +1 more source