Results 61 to 70 of about 121,067 (251)

Positive associations between triglyceride-glucose (TyG) and TyG-body mass index (TyG-BMI) with cardiovascular disease in patients with psoriasis: cross-sectional results from the SPEECH

Frontiers in Immunology
BackgroundPatients with psoriasis have an increased risk of developing cardiovascular disease(CVD), yet reliable potential markers for cardiovascular risk assessment remain insufficient.
Ying Li, Ying Li, Dawei Huang, Dawei Huang, Biao Ma, Biao Ma, Yuxiong Jiang, Yuxiong Jiang, Bo Yu, Bo Yu, Jianfeng Zheng, Jianfeng Zheng, Yangfeng Ding, Yangfeng Ding, Yuling Shi, Yuling Shi   +15 more
doaj   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Botulinum Toxin A in Treatment of Facial Flushing

Acta Medica Iranica, 2016
Flushing is a condition with episodic attacks of redness of the skin with a sensation of warmth or burning, this disease causes emotional and functional problems in patients.
Gholamreza Eshghi, Leila Khezrian, Pedram Alirezaei   +2 more
doaj  

Development and validation of a prediction model for primary non-response to IL-17A inhibitors in psoriasis

Frontiers in Medicine
BackgroundInterleukin-17A (IL-17A) inhibitors have revolutionized the treatment of moderate-to-severe plaque psoriasis, but a substantial proportion of patients experience primary non-response during the early treatment phase.ObjectivesTo identify ...
Qian Yu, Qian Yu, Yuxiong Jiang, Yuxiong Jiang, Yifan Hu, Yifan Hu, Min Dai, Min Dai, Siqi Li, Siqi Li, Jiangluyi Cai, Jiangluyi Cai, Nan Yang, Nan Yang, Yuanwenke Zhang, Yuanwenke Zhang, Yuemeng Huang, Yuemeng Huang, Chunyuan Guo, Chunyuan Guo, Yuling Shi, Yuling Shi, Jiajing Lu, Jiajing Lu   +23 more
doaj   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Comparison between Intralesional Triamcinolone and Kligman's Formula in Treatment of Melasma

Acta Medica Iranica, 2016
Melasma is a common acquired skin disorder. While different treatments are currently being used, in many cases it is refractory to treatment. According to the effects of topical steroids in decreasing skin pigmentation, we studied the efficacy of this ...
Gholamreza Eshghi, leila khezrian, Fariba Esna Ashari   +2 more
doaj  

Epigenetic control of tissue resident memory T cells

Frontiers in Immunology
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a ...
Zhiyi Lan, Zhiyi Lan, Zhiyi Lan, Zeyu Chen, Zeyu Chen, Nan Yang, Nan Yang, Tong Liu, Tong Liu, Siqi Li, Siqi Li, Yuling Shi, Yuling Shi, Jun Gu, Jun Gu   +14 more
doaj   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Viewing Psoriasis as a Systemic Disease for Better Health Outcomes

JID Innovations, 2021
George C. Gondo, Samantha Koons, Claire Metcalf, Stacie J. Bell, Nehal N. Mehta   +4 more
doaj   +1 more source