Results 41 to 50 of about 166,859 (297)

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Janus kinase inhibitors in autoimmune bullous diseases

Frontiers in Immunology, 2023
Autoimmune bullous disease (AIBD) is a severe skin disorder caused by autoantibodies that target intercellular or cell-matrix adhesion proteins.
Dawei Huang, Dawei Huang, Yuexin Zhang, Yuexin Zhang, Luyang Kong, Luyang Kong, Jiajing Lu, Jiajing Lu, Yuling Shi, Yuling Shi   +9 more
doaj   +1 more source

NOS2-derived low levels of NO drive psoriasis pathogenesis

Cell Death and Disease
Psoriasis is an IL-23/Th17-mediated skin disorder with a strong genetic predisposition. The impact of its susceptibility gene nitric oxide synthase 2 (NOS2) remains unknown.
Ines Köhler, Cecilia Bivik Eding, Nada-Katarina Kasic, Deepti Verma, Charlotta Enerbäck   +4 more
doaj   +1 more source

Clinical and epidemiologic features of psoriasis patients in an Egyptian medical centerCapsule Summary

JAAD International, 2020
Background: Identification of epidemiologic and phenotypic variations of psoriasis among different ethnic groups can further our understanding of this perplexing disease, aiming at better management of patients worldwide.
Mohamed Hussein Medhat El-Komy, MD, Heba Mashaly, MD, Khadiga S. Sayed, MD, Vanessa Hafez, MD, Marwa S. El-Mesidy, MD, Eman R. Said, MD, Marwa A. Amer, MD, Aya M. AlOrbani, MD, Dina G. Saadi, MD, Mona El-Kalioby, MD, Reem O. Eid, MSc, Yousra Azzazi, MSc, Hagar El Sayed, MD, Nesrin Samir, MD, Marwa R. Salem, MD, Eman D. El Desouky, MD, Hesham Abd El-Moaty Zaher, MD, Hoda Rasheed, MD   +17 more
doaj   +1 more source

Polyethylene Glycol Ointment Alleviates Psoriasis-Like Inflammation Through Down-Regulating the Function of Th17 Cells and MDSCs

Frontiers in Medicine, 2021
Objective: To explore the possible mechanism of improving the imiquimod (IMQ)-induced psoriasis-like inflammation by using polyethylene glycol (PEG) ointment.Methods: We evaluated the appearance of psoriasis lesions by Psoriasis Area and Severity Index ...
Yan Lu, Yan Lu, Yi Xiao, Yi Xiao, Ming-Zhu Yin, Ming-Zhu Yin, Xing-Chen Zhou, Li-Sha Wu, Li-Sha Wu, Wang-Qing Chen, Yan Luo, Yan Luo, Ye-Hong Kuang, Ye-Hong Kuang, Wu Zhu, Wu Zhu   +15 more
doaj   +1 more source

Psoriasis treatment

, 2021
The thesis is about the treatment options for psoriasis. Psoriasis is a chronic inflammatory disease that characteristically causes cutaneous manifestations. Its typical locations, classifications, and symptoms are also discussed.
Iftikhar, Sandleen
core  

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

White Sponge Nevus: Report of a Case and Review of the Literature

Acta Medica Iranica, 2017
White sponge nevus is a rare benign autosomal dominant disorder with variable penetrance. It is characterized by asymptomatic white plaques affecting mainly the oral mucosa. Careful clinical and histopathological examination is indicated to exclude other
Mohammadreza Sobhan, Pedram Alirezaei, Mahmood Farshchian, Gholamreza Eshghi, Hamid Reza Ghasemi Basir, Leila Khezrian   +5 more
doaj