Results 101 to 110 of about 11,862,011 (403)

Treatment of severe psoriasis

Journal of the European Academy of Dermatology and Venereology, 2012
AbstractDespite the great advances brought about by biologic therapies, treatment of moderate‐to‐severe psoriasis often represents a challenge. Associated comorbidities may hamper the use of ciclosporin or methotrexate at effective doses, and obesity or heavy weight reduce the therapeutic expectations of systemic treatments, especially with regard to ...
openaire   +3 more sources

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial [PDF]

, 2015
Background: Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients ...
Conaghan, Philip G., Gottlieb, Alice B., Kavanaugh, Arthur, Kirkham, Bruce, Landewé, Robert, Ligozio, Gregory, McInnes, Iain B., Mease, Philip J., Mpofu, Shephard, Patekar, Manmath, Pricop, Luminita, Rahman, Proton, Richards, Hanno, Ritchlin, Christopher T., van der Heijde, Désirée   +14 more
core   +1 more source

Efficacy and Safety of Continuous Risankizumab Therapy vs Treatment Withdrawal in Patients With Moderate to Severe Plaque Psoriasis

JAMA dermatology, 2020
Key Points Question Is continuous risankizumab treatment efficacious and safe in adults with moderate to severe plaque psoriasis? Findings In this 2-part, phase 3 randomized clinical trial in 507 patients, a significantly greater proportion of patients ...
A. Blauvelt, C. Leonardi, M. Gooderham, K. Papp, S. Philipp, Jashin J. Wu, A. Igarashi, M. Flack, Z. Geng, Tianshuang Wu, A. Camez, D. Williams, R. Langley   +12 more
semanticscholar   +1 more source

Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1

Advanced Science, EarlyView.
Through elaborate design, a biodegradable scaffold with excellent mechanical properties and suitability is fabricated, providing spatial support for subsequent physiological activities. The prepared GA‐HBC‐LIC hydrogel possesses sequential antibacterial, antioxidant, anti‐inflammatory and immunomodulatory functions, offering a suitable chemical and ...
Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou   +9 more
wiley   +1 more source

Treatment of psoriasis with biologic agents in Malta [PDF]

, 2016
Introduction: Biologic therapy has revolutionalised the treatment of moderate to severe psoriasis leading to improved clinical outcomes and quality of life scores.
Aquilina, Susan, Boffa, Michael J., Clark, Eileen, Mercieca, Liam, Scerri, Lawrence   +4 more
core  

Treatment recommendations for psoriatic arthritis [PDF]

, 2008
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion.
Boehncke, Wolf-Henning, Fiorentino, David, FitzGerald, Oliver, Gladman, Dafna D., Gottlieb, Alice B., Helliwell, Philip, Kavanaugh, Arthur, McHugh, Neil J., Mease, Philip J., Nash, Peter, Qureshi, Abrar A., Ritchlin, Christopher T., Soriano, Enrique R., Taylor, William J., Vlam, Kurt de   +14 more
core   +2 more sources

Upadacitinib in nail psoriasis: a case report

Journal of Dermatological Treatment, 2023
The purpose of the article Nail psoriasis is a refractory disease that affects 50–79% skin psoriasis patients and up to 80% of patients with psoriatic arthritis (PsA).
Na Wang, Qing Yang, Yongxia Liu, Hong Liu   +3 more
doaj   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

Perceptions on the treatment of psoriasis

Journal of Dermatological Treatment, 2005
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openaire   +3 more sources