Results 121 to 130 of about 59,113 (302)

Clinical trial eligibility in PSP: Population representativeness and potential criteria adjustment based on PSP-NET findings

Background: Progressive Supranuclear Palsy (PSP) is a rare, heterogeneous neurodegenerative disease for which no treatment is currently available. In the context of clinical trials, the representativeness of the included patients is crucial for the ...
Picillo, Marina, Sambati, Luisa, Del Prete, Eleonora, Cani, Ilaria, Ciammola, Andrea, Fabbrini, Giovanni, Padovani, Alessandro, Frosini, Daniela, Pilotto, Andrea, Abate, Filomena, Soricelli, Andrea, Capecci, Marianna, Marchese, Roberta, Borroni, Barbara, Calandra-Buonaura, Giovanna, Di Biasio, Francesca, Ticozzi, Nicola, Schirinzi, Tommaso, Barone, Paolo, in PSP-NET study group, Markushi, Tiziana Benzi, Costanzo, Matteo, Stefani, Alessandro   +22 more
core   +1 more source

Um modelo eficiente do transistor MOS para o projeto de circuitos VLSI: [dissertação] [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Neste trabalho é detalhada a implementação do modelo ACM do transistor MOS no simulador elétrico ELDO (Mentor Graphics).
Siebel, Osmar Franca
core  

An LC-MS Method for PSP Toxins

, 2000
Paralytic shellfish poisoning (PSP) toxins are potent neurotoxins produced by several marine dinoflagellates. The accumulation of these toxins in wild and cultured shellfish during "red tide" episodes can have serious economic and public health ...
DELL'AVERSANO, CARMELA, P. Hess, M. Quilliam   +2 more
core  

Should Paratonia Be Considered a Movement Disorder? Implications for Clinical Management

Movement Disorders Clinical Practice, EarlyView.
Abstract Paratonia is an involuntary and variable resistance to passive movement that emerges with cognitive decline in dementias of different etiologies, with prevalence approaching 90% to 100% in end‐stage disease. It is common in Parkinson disease and the atypical parkinsonisms.
Galit Kleiner, Christos Ganos, Anthony E. Lang   +2 more
wiley   +1 more source

Spatiotemporal Tau Accumulation and its Clinical Impact on Progressive Supranuclear Palsy: Longitudinal Florzolotau (18F) Positron Emission Tomography

Movement Disorders, EarlyView.
Abstract Background Florzolotau (18F) positron emission tomography (florzolotau PET) enables high‐contrast in vivo detection of four‐repeat tau pathology in progressive supranuclear palsy (PSP), but whether longitudinal tau imaging reflects disease progression remains unclear.
Yoshikazu Chishiki, Kenji Tagai, Yuko Kataoka, Ryoji Goto, Kenta Osawa, Asaka Oyama, Hideki Matsumoto, Masanori Ichihashi, Yuki Momota, Tetsuji Kamada, Chie Seki, Kiwamu Matsuoka, Kosei Hirata, Shin Kurose, Sho Moriguchi, Yuki Komatsu, Hideo Kato, Yasuharu Yamamoto, Yoshikazu Nakano, Shigeki Hirano, Hitoshi Shinotoh, Hitoshi Shimada, Tokahiko Tokuda, Kazunori Kawamura, Ming‐Rong Zhang, Keisuke Takahata, Makoto Higuchi, Hironobu Endo   +27 more
wiley   +1 more source

Performance of a Two-Week Rehabilitation Improves Motor Function in Inpatients with Progressive Supranuclear Palsy: A Pre–Post Study

Brain Sciences
Background: Progressive supranuclear palsy (PSP) is characterized by early postural instability and gait dysfunction, with frequent falls. Rehabilitation is an important therapeutic approach for motor dysfunction in patients with PSP.
Naomi Matsuda, Yasuyuki Takamatsu, Makoto Sawada, Ikuko Aiba   +3 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby   +127 more
wiley   +1 more source

ATXN8OS Intermediate Expansion Acts as a Genetic Modifier in Spinocerebellar Ataxia Type 48 (SCA48/STUB1)

Movement Disorders, EarlyView.
Abstract Background Association between monoallelic STUB1 variant and expanded ATXN8OS alleles was recently reported, suggesting a pathogenic interaction that may influence spinocerebellar ataxia type 48 (SCA48) phenotype. Objectives We investigated the frequency and clinical impact of ATXN8OS in a large cohort of STUB1 carriers compared to individuals
Charlotte Mouraux, Jean‐Loup Méreaux, Claire‐Sophie Davoine, Léna Guillot Noel, Emilien Petit, Quentin Thomas, Adem Nasraoui, Anna Heinzmann, Claire Ewenczyk, Alexis Brice, Alexandra Durr, Giulia Coarelli   +11 more
wiley   +1 more source

Synucleinopathy-like clinical features and biologically defined synuclein seeding in PSP-Parkinsonism: an imperfect match

npj Parkinson's Disease
Whether synucleinopathy-like (syn-like) symptoms match biologically defined synuclein seeding in PSP-parkinsonism (PSP-P) vs. Parkinson’s disease (PD) remains unexplored. We studied 80 subjects: 20 PSP-P, 20 PSP-Richardson-syndrome(PSP-RS), 20 PD, and 20
Celia Painous, Andrea Martínez, Ana Camara, Manel Fernandez, Maria J. Marti, Esteban Muñoz, Almudena Sánchez-Gómez, Alexandra Pérez-Soriano, Alicia Garrido, Carla Brenlla, Francesc Valldeoriola, Eduard Tolosa, Nuria Caballol, Serge Jaumà, Claustre Pont-Sunyer, Tania Delgado, Albert Lladó, Jesica Pérez-Montesino, Lorena de Mena, Laura Naranjo, Raquel Ruiz-García, Laura Molina-Porcel, Iban Aldecoa, Barcelona PSP Registry Consortium, Joan Santamaria, Yaroslau Compta   +25 more
doaj   +1 more source

Using participatory scenario planning to explore the synergies and trade‐offs from upland treescape expansion

People and Nature, EarlyView.
Abstract The future of land use in the UK uplands is highly debated, with growing interest in increasing tree cover and other land use changes, alongside a desire to maintain traditional land use patterns and practices. Treescape expansion is likely to result in synergies and trade‐offs between different outcomes, so integrating stakeholder preferences
Melissa Minter, Susan Baker, Euan Bowditch, Sheena Carlisle, Natasha Constant, Alix Syder, Tom Finch   +6 more
wiley   +1 more source