Results 41 to 50 of about 2,026 (172)

A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics

Biology, 2023
Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders. This review delves into the intricate cellular neurobiology of psychedelics, emphasizing their potential ...
Blerida Banushi, Vince Polito
doaj   +1 more source

Paradoxical pharmacological dissociations result from drugs that enhance delta oscillations but preserve consciousness

Communications Biology, 2023
Low-frequency (
Joel Frohlich, Pedro A. M. Mediano, Francesco Bavato, Alireza Gharabaghi   +3 more
doaj   +1 more source

Neurochemical and Behavioral Profiling in Male and Female Rats of the Psychedelic Agent 25I-NBOMe [PDF]

Frontiers in Pharmacology, 2019
4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe), commonly called "N-Bomb," is a synthetic phenethylamine with psychedelic and entactogenic effects; it was available on the Internet both as a legal alternative to lysergic acid diethylamide (LSD) and as a surrogate of 3,4-methylenedioxy-methamphetamine (MDMA), but now it has been ...
Cristina Miliano, Matteo Marti, Matteo Marti, Matteo Marti, Nicholas Pintori, Maria Paola Castelli, Maria Paola Castelli, Micaela Tirri, Raffaella Arfè, Raffaella Arfè, Maria Antonietta De Luca, Maria Antonietta De Luca   +11 more
openaire   +5 more sources

Psychedelics for depression: from neurobiology to treatment

European Psychiatry, 2023
Decades ago, the classical psychedelics psilocybin and LSD entered the therapeutic setting and already then showed their therapeutic potential in the treatment of psychiatric disorders. For thousands of years another psychedelic, ayahuasca, is being used
K. P. Kuypers
doaj   +1 more source

Experimental Therapeutics in Treatment-Resistant Major Depressive Disorder

Journal of Experimental Pharmacology, 2021
Mandeep Kaur,1 Marsal Sanches2 1Department of Behavioral Medicine, Cone Health, Greensboro, NC, USA; 2UT Health Center of Excellence on Mood Disorders, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX ...
Kaur M, Sanches M
doaj  

In Silico Studies on Psilocybin Drug Derivatives Against SARS-CoV-2 and Cytokine Storm of Human Interleukin-6 Receptor

Frontiers in Immunology, 2022
Various metabolites identified with therapeutic mushrooms have been found from different sources and are known to have antibacterial, antiviral, and anticancer properties.
Faez Iqbal Khan, Fakhrul Hassan, Dakun Lai   +2 more
doaj   +1 more source

Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors

Frontiers in Pharmacology, 2023
Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists.
Prithvi Hemanth, Pallavi Nistala, Vy T. Nguyen, Jose M. Eltit, Richard A. Glennon, Małgorzata Dukat   +5 more
doaj   +1 more source

Understanding Consumption of Illicit Drugs and New Psychoactive Substances in Australia by Triangulating Drug Checking and Wastewater‐Based Epidemiology

Drug Testing and Analysis, EarlyView.
First Australian study combining wastewater‐based epidemiology and drug checking, demonstrating how complementary data sources enhance monitoring of illicit drugs and emerging psychoactive substances during high‐use periods. ABSTRACT Consumption of psychotropic drugs is a major economic and public health challenge in Australia.
Muhammad Usman, Malcolm McLeod, Dhayaalini Nadarajan, Joseph Clokey, Pritesh Prasad, Rory Verhagen, Benjamin Tscharke, Maurizio Quinto, Richard Bade   +8 more
wiley   +1 more source

The psychedelic renaissance: psilocybin, a breakthrough for treatment resistant depression? [PDF]

Exploration of Neuroscience
Treatment resistant depression (TRD) is frequently encountered in clinical practice. The lack of response of the condition to conventional medications and augmentation strategies has spawned the search for novel treatment approaches.
Trevor R. Norman
doaj   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source