Results 81 to 90 of about 10,405 (213)

Gold Teeth: Making Meaning through Narrative [PDF]

open access: yes, 2017
How do we create meaning in life through the telling of narratives? What do we have to gain by comparing stories from different cultures and times? By looking at two seemingly disparate stories - The Story of Kotikarna and Thomas Pynchon\u27s Inherent ...
Riesenman, Quinn
core   +1 more source

'Loss of control' in alcoholism and drug addiction:A neuroscientific interpretation [PDF]

open access: yes, 2000
Considerable neurological evidence indicates that the prefrontal cortex mediates complex 'executive' functions including behavioral autonomy and self-control.
Lyvers, M.
core   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

open access: yesBritish Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

A Model for Configuration Management of Open Software Systems [PDF]

open access: yes, 2010
The article proposes a model for the configuration management of open systems. The model aims at validation of configurations against given specifications. An extension of decision graphs is proposed to express specifications.
Barbuti, Roberto   +2 more
core  

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli   +8 more
wiley   +1 more source

Creativity and psychoactive substance use: a systematic review [PDF]

open access: yes, 2017
The role of psychoactive substance use in the research of artistic creation and creativity is a long-standing topic. Ever since the discovery of LSD, researchers have examined the relationship between the effects of chemical substances and the artistic ...
Demetrovics, Z, Griffiths, MD, Iszáj, F
core   +1 more source

Discovering the Self: A Grounded Theory of Women's Recovery From Gender‐Based Religious Harm

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim(s) This study defines adverse religious experiences (AREs), describes how these gendered harms affect women and develops a Classical Grounded Theory (CGT) model of women's recovery and inform trauma‐ and gender‐responsive nursing practice.
Beth K. Schwartz, Pamela H. Cone
wiley   +1 more source

Novel treatments of depression: bridging the gap in current therapeutic approaches

open access: yesExploration of Neuroscience
Depression poses a significant global health burden, yet current therapeutic approaches focusing on monoaminergic neurotransmission often fall short of achieving full remission and managing acute episodes effectively.
Amit Jagtiani
doaj   +1 more source

Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice [PDF]

open access: yes, 2018
Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T.
Akinyeke, Tunde   +11 more
core   +2 more sources

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