Results 91 to 100 of about 2,026 (172)

Neural signaling mechanisms in depression: bridging classical monoamine hypotheses, animal models, and emerging antidepressant strategies

Frontiers in Cell and Developmental Biology
Major depressive disorder is a highly prevalent psychiatric condition that can affect individuals across the lifespan, yet its pathophysiology remains incompletely understood. Classical hypotheses, informed by preclinical and clinical studies, emphasized
Mizuki Yamamoto, Haruka Hirakata, Koji Toda   +2 more
doaj   +1 more source

Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure

Frontiers in Neurology
IntroductionMany Veterans who experienced blast-related traumatic brain injuries (TBIs) in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD).
Rita De Gasperi, Rita De Gasperi, Georgina Perez Garcia, Georgina Perez Garcia, Miguel A. Gama Sosa, Miguel A. Gama Sosa, Gissel M. Perez, Rania Abutarboush, Rania Abutarboush, Usmah Kawoos, Usmah Kawoos, Patrick R. Hof, Patrick R. Hof, Patrick R. Hof, Carolyn W. Zhu, Carolyn W. Zhu, Carolyn W. Zhu, Stephen T. Ahlers, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder   +21 more
doaj   +1 more source

Effects of MDMA-assisted therapy for PTSD on self-experience.

PLoS ONE
IntroductionThere is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA).
Bessel A van der Kolk, Julie B Wang, Rachel Yehuda, Leah Bedrosian, Allison R Coker, Charlotte Harrison, Michael Mithoefer, Berra Yazar-Klosinki, Amy Emerson, Rick Doblin   +9 more
doaj   +1 more source

THE PROTOTYPICAL PSYCHEDELIC AGENT LSD PRODUCES RAPID ANTIDEPRESSANT EFFECTS VIA 5-HT2B RECEPTOR ACTIVATION

International Journal of Neuropsychopharmacology
Abstract Background Recent clinical trials reveal that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), present a promising potential for treating psychiatric disorders, including treatment-resistant depression.
Bouloufa, Amel, Delcourte, Sarah, Rovera, Renaud, Dkhissi-Benyahya, Ouria, Haddjeri, *Nasser   +4 more
openaire   +1 more source

Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence

Cancer Reports
Background Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism‐based framework for managing cancer‐related depression by exploring its unique pathophysiology ...
Sepideh Hajivalizadeh, Kimia Farahmand, Kimia Kazemzadeh, Ghazaleh Hajivalizadeh, Ahmad Shamabadi   +4 more
doaj   +1 more source

Short-term safety and tolerability profile of 5-methoxy-N,N-dimethyltryptamine in human subjects: a systematic review of clinical trials

Frontiers in Psychiatry
IntroductionPsychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel ...
Aleksander Kwaśny, Alina Wilkowska, Wiesław Jerzy Cubała   +2 more
doaj   +1 more source

Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?

Frontiers in Human Neuroscience
Developmental stuttering (DS) is a neurodevelopmental speech-motor disorder characterized by symptoms such as blocks, repetitions, and prolongations. Persistent DS often has a significant negative impact on quality of life, and interventions for it have ...
Giuseppe Pasculli, Giuseppe Pasculli, Pierpaolo Busan, Eric S. Jackson, Per A. Alm, Per A. Alm, Danilo De Gregorio, Danilo De Gregorio, Gerald A. Maguire, Gerald A. Maguire, Guy M. Goodwin, Gabriella Gobbi, David Erritzoe, Robin L. Carhart-Harris, Robin L. Carhart-Harris   +14 more
doaj   +1 more source

“” A Qualitative Analysis of Patient Perspectives on Psychedelic-Assisted Therapy for Cancer-Related Psychosocial Symptoms

Integrative Cancer Therapies
People living with cancer (PLWC) often face profound existential distress that is insufficiently addressed by conventional psychosocial supports. This qualitative study explored PLWC’s attitudes, beliefs, and experiences regarding psychedelic-assisted ...
Haley D.M. Schuman BSc, Sofia Barkova PhD, Raèf Mina BSc, Julie M. Deleemans PhD, Tina Nguyen BSc, Linda E. Carlson PhD   +5 more
doaj   +1 more source

Novel Serotonergic Psychedelic Agents as 5-HT2A Agonists for Treating Psychosis, Mental Illness, and CNS Disorders

ACS Medicinal Chemistry Letters
Provided herein are novel serotonergic psychedelic agents as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating psychosis, mental illness and central nervous system (CNS) disorders, and processes for preparing such compounds.
openaire   +2 more sources

Novel N-Substituted Indole Derivatives as Serotonergic Psychedelic Agents for Treating Psychosis, Mental Illness, and CNS Disorders

ACS Medicinal Chemistry Letters
Provided herein are novel N-substituted indole derivatives as serotonergic psychedelic agents, pharmaceutical compositions, use of such compounds in treating psychosis, mental illness and central nervous system (CNS) disorders, and processes for preparing such compounds.
openaire   +2 more sources