Results 101 to 110 of about 1,473,533 (284)

Aberrant functional connectivity between the amygdala and the temporal pole in drug-free generalized anxiety disorder

Frontiers in Human Neuroscience, 2016
The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in emotion dysregulation, which has a profound impact on etiologic research of generalized anxiety disorder (GAD).
Wei Li, Huiru Cui, Zhipei Zhu, Li Kong, Qian Guo, Yikang Zhu, Qiang Hu, Lanlan Zhang, Hui Li, Qingwei Li, Jiangling Jiang, Jordan Meyers, Jianqi Li, Jijun Wang, Jijun Wang, Jijun Wang, Zhi Yang, Chunbo Li, Chunbo Li, Chunbo Li   +19 more
doaj   +1 more source

Neurodevelopmental Mechanisms for Psychotic Disorders

, 2017
The current understanding of the mechanisms underlying psychotic disorders, including schizophrenia, is far from satisfactory and has hampered the establishment of effective treatments, as well as accurate diagnosis and prognosis in patients.
Nao J. Gamo, Akira Sawa, Hanna Jaaro-Peled, Takeshi Sakurai   +3 more
core   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

RBANS change from baseline to follow-up for schizophrenia spectrum disorders vs. other psychotic disorders.

, 2016
RBANS change from baseline to follow-up for schizophrenia spectrum disorders vs. other psychotic disorders.
Liss Anda (3559055), Else-Marie Løberg (3559058), Erik Johnsen (3559043), Hugo Jørgensen (3559046), Kolbjørn S. Brønnick (3559052), Rune A. Kroken (3559049)   +5 more
core   +1 more source

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Copula‐based joint modelling of emergency department visits with time‐varying dependence

Canadian Journal of Statistics, EarlyView.
Abstract Jointly modelling multiple correlated count time series is essential in health services research, where outcomes like emergency visits for mental health and substance use often evolve together. Ignoring these dependencies can obscure meaningful trends and limit the effectiveness of policy evaluation.
Guanjie Lyu, Cindy Feng, Lihui Liu
wiley   +1 more source

Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Molecular Brain, 2017
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory.
Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He, Ying Zhou, Weidong Li   +17 more
doaj   +1 more source

Irregular visits in longitudinal studies: Comparing inverse intensity of visit weighting and imputation in a causal analysis of antidepressant therapeutic treatment

Canadian Journal of Statistics, EarlyView.
Abstract Irregular observation times are common in longitudinal observational studies and can affect causal inferences. We use data from electronic health records of Kaiser Permanente Washington patients in the United States who initiated an antidepressant medication between 2008 and 2018, with a confirming diagnosis of depression. We are interested in
Janie Coulombe, Erica E. M. Moodie, Susan M. Shortreed   +2 more
wiley   +1 more source

Forest plot 12-month prevalence of psychotic disorders.

, 2018
Forest plot 12-month prevalence of psychotic disorders.
Loly Pastor (5095199), Berta Moreno-Küstner (539756), Carlos Martín (5094395)   +2 more
core   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source