Results 91 to 100 of about 1,403,553 (284)

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Differential effects of cognitive training and aerobic exercise on regional gray matter volume and inter-regional covariance in community-dwelling older adults

Scientific Reports
Previous studies have shown that both cognitive training and aerobic exercise benefit cognition and brain structure in healthy older adults, yet direct comparisons are limited. This study aimed to compare the effects of three months of cognitive training
Lijuan Jiang, Xinyi Cao, Ting Li, Kai Wei, Shaohui Lin, Junjie Yang, Nannan Gu, Yang Hu, Chunbo Li   +8 more
doaj   +1 more source

A case report of dissociative conversion disorder primarily manifesting as intermittent fainting accompanied by myoclonic seizures

Shanghai Jiaotong Daxue xuebao. Yixue ban
The characteristic features of dissociative conversion disorder entail a partial or complete loss of normal integration in memory, identity awareness, immediate sensation, and motor control.
TANG Peiyuan, WANG Chongze, HONG Wu, FEI Hui, YI Zhenghui, LÜ Qinyu   +5 more
doaj   +1 more source

Aberrant functional connectivity between the amygdala and the temporal pole in drug-free generalized anxiety disorder

Frontiers in Human Neuroscience, 2016
The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in emotion dysregulation, which has a profound impact on etiologic research of generalized anxiety disorder (GAD).
Wei Li, Huiru Cui, Zhipei Zhu, Li Kong, Qian Guo, Yikang Zhu, Qiang Hu, Lanlan Zhang, Hui Li, Qingwei Li, Jiangling Jiang, Jordan Meyers, Jianqi Li, Jijun Wang, Jijun Wang, Jijun Wang, Zhi Yang, Chunbo Li, Chunbo Li, Chunbo Li   +19 more
doaj   +1 more source

Comparing the prodrome of schizophrenia-spectrum psychoses and affective disorders with and without psychotic features

, 2012
Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed.
Schultze-Lutter, Frauke, Schimmelmann, Benno G, Klosterkötter, Joachim, Ruhrmann, Stephan   +3 more
core   +1 more source

Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]

, 2002
Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Hummel, B., Amann, B., Forsthoff, A., Matzner, N., Dittmann, Sandra, Grunze, Heinz   +5 more
core   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers

British Journal of Clinical Pharmacology, EarlyView.
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi, Pramod Chandru, Naren Gunja, Nancy Briggs, Betty S. Chan   +6 more
wiley   +1 more source

Differences in visual attention processing: An event-related potential comparative analysis within psychotic disorders

, 2019
>Magister Scientiae - MScINTRODUCTION: Sustained attention is known to be dysfunctional in psychotic disorders. Sustained attention is the ability to remain focused on a specific time-locked stimulus within a task. We aimed to determine whether there are
Williams, Kimberley Clare
core  

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Pathways between childhood victimization and psychosis-like symptoms in the ALSPAC Birth Cohort [PDF]

, 2013
Background: Several large population-based studies have demonstrated associations between adverse childhood experiences and later development of psychotic symptoms.
Lewis, G., Maughan, B., Fisher, H. L., Lewis, Glyn, Fisher, Helen L; id_orcid, Schreier, Andrea, Lewis, Glyn H, Maughan, Barbara, Maughan, Barbara; id_orcid, Munafo, Marcus R., Wolke, D., Wolke, Dieter, Fisher, H., Zammit, Stanley, Munafò, Marcus R, Munafo, M. R., Schreier, A.   +16 more
core   +1 more source