Results 111 to 120 of about 1,473,533 (284)

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations

Frontiers in Synaptic Neuroscience
BackgroundSynaptic pruning is a critical neurodevelopmental process that eliminates redundant or weak synaptic connections to optimize brain circuitry. In schizophrenia, converging evidence from imaging, genetic, and postmortem studies suggests that this
Agnieszka Pawlak, Jakub Stefanowicz, Zofia Kotkowska, Agata Gabryelska, Marcin Sochal, Filip Napieraj, Magdalena Kotlicka-Antczak, Dominik Strzelecki   +7 more
doaj   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

Drug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum, Shao‐Hsin Hung, Meng‐Tsang Hsieh, Mei‐Chich Hsu, William Chih‐Wei Chang   +4 more
wiley   +1 more source

Transcriptome analysis to explore the mechanism of downregulated TNIK influencing the effect of risperidone

Frontiers in Pharmacology
BackgroundRisperidone is one of the most reliable and effective antipsychotics for schizophrenia treatment. However, the mechanism of action of risperidone is not yet fully understood.
Ruixue Yuan, Yaojing Li, Xiangyi Li, Yingmei Fu, Ailing Ning, Dongxiang Wang, Ran Zhang, Shunying Yu, Qingqing Xu   +8 more
doaj   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Excess Mortality Among Patients With Anorexia Nervosa Treated Involuntarily

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity and increased relative mortality compared to the general population. Involuntary treatment (IT) is implemented after exhausting voluntary treatment options. This study investigates mortality in patients with AN following IT, using IT as an indicator of patient
Line Bager, Katrine Holde, Janne Tidselbak Larsen, Loa Clausen, Zeynep Yilmaz, Benjamin Mac Donald, Liselotte Vogdrup Petersen   +6 more
wiley   +1 more source

Neighborhood Disadvantage and Comorbid Mental Health Conditions in Adolescents and Young Adults With Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anxiety and depression are highly prevalent among adolescents and young adults with eating disorders. A comorbid mental health condition is associated with worsened long‐term eating disorder outcomes. While individual risk factors for comorbid anxiety or depression and eating disorders have been elucidated, the impact of external ...
Anita V. Chaphekar, Qing Duan, Janet Zahner, Andrew F. Beck   +3 more
wiley   +1 more source

Two bipolar disorders or one? In reply to commentary by Malhi and Bell

International Journal of Bipolar Disorders, 2022
Leonardo Tondo, Alessandro Miola, Marco Pinna, Martina Contu, Ross J. Baldessarini   +4 more
doaj   +1 more source

Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: A study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder

, 2018
Electroencephalography (EEG) has been proposed as a neurophysiological biomarker to delineate psychotic disorders. It is known that increased delta and decreased alpha, which are apparent in psychosis, are indicative of inappropriate arousal state, which
Temmingh, H.S, Stein, D.J, Hsieh, J.H, van Dijen, A.V, Baldwin, D.S, Howells, F.M   +5 more
core   +1 more source

Evaluating the Feasibility, Acceptability, and Preliminary Effectiveness of Interprofessional Enhanced Cognitive Behavior Therapy for Anorexia Nervosa and Atypical Anorexia Nervosa: A Pilot Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Enhanced Cognitive Behavior Therapy (CBT‐E) is the leading outpatient treatment for eating disorders but is typically delivered by a single clinician and does not routinely incorporate interprofessional expertise. In broader healthcare settings, Interprofessional collaborative practice (IPCP), characterized by role clarity, shared ...
Megan Bray, Gabriella Heruc, Susan Byrne, Kate Fleming, Olivia R. L. Wright   +4 more
wiley   +1 more source