Results 71 to 80 of about 113,903 (250)

Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Molecular Brain, 2017
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory.
Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He, Ying Zhou, Weidong Li   +17 more
doaj   +1 more source

Psychotropic medication use among community dwellers with and without Parkinson's disease – A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims We studied the prevalence of psychotropic use and psychotropic polypharmacy in persons with Parkinson's disease (PD) during a 10‐year follow‐up, because longitudinal studies on this topic are scarce although non‐motor symptoms of PD are often treated with psychotropics.
Noora Nieminen, Anna‐Maija Tolppanen, Valtteri Kaasinen, Marjaana Koponen, Sirpa Hartikainen   +4 more
wiley   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations

Frontiers in Synaptic Neuroscience
BackgroundSynaptic pruning is a critical neurodevelopmental process that eliminates redundant or weak synaptic connections to optimize brain circuitry. In schizophrenia, converging evidence from imaging, genetic, and postmortem studies suggests that this
Agnieszka Pawlak, Jakub Stefanowicz, Zofia Kotkowska, Agata Gabryelska, Marcin Sochal, Filip Napieraj, Magdalena Kotlicka-Antczak, Dominik Strzelecki   +7 more
doaj   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Transcriptome analysis to explore the mechanism of downregulated TNIK influencing the effect of risperidone

Frontiers in Pharmacology
BackgroundRisperidone is one of the most reliable and effective antipsychotics for schizophrenia treatment. However, the mechanism of action of risperidone is not yet fully understood.
Ruixue Yuan, Yaojing Li, Xiangyi Li, Yingmei Fu, Ailing Ning, Dongxiang Wang, Ran Zhang, Shunying Yu, Qingqing Xu   +8 more
doaj   +1 more source

Dynamic Functional Connectivity Within the Fronto-Limbic Network Induced by Intermittent Theta-Burst Stimulation: A Pilot Study

Frontiers in Neuroscience, 2019
PurposeThe utility of transcranial magnetic stimulation (TMS) has been growing rapidly in both neurocognitive studies and clinical applications in decades.
Yingying Tang, Yingying Tang, Xiong Jiao, Xiong Jiao, Junjie Wang, Junjie Wang, Tianyuan Zhu, Jie Zhou, Jie Zhou, Zhenying Qian, Tianhong Zhang, Huiru Cui, Hui Li, Xiaochen Tang, Lihua Xu, Ling Zhang, Yanyan Wei, Jianhua Sheng, Liu Liu, Jijun Wang, Jijun Wang, Jijun Wang   +21 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Applying the Rules of Evidence to Expert Testimony About Risk

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Expert opinion about dangerousness or risk is common at sentencing, criminal commitment proceedings and some types of pretrial detention hearings. This article argues that such evidence must be (1) “material” (logically relevant, empirically generalizable, and epistemologically germane), (2) “probative” (a measure of accuracy, which is ...
Christopher Slobogin
wiley   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source