Results 61 to 70 of about 114,482 (250)

Stage-dependent patterns of cognitive network connectivity in early psychosis

Nature Communications
Cognitive impairments in early psychosis are common, yet prior studies have focused mainly on domain-specific deficits rather than inter-domain relationships.
XiaoChen Tang, YanYan Wei, JiaoYan Pang, LiHua Xu, HuiRu Cui, MingLiang Ju, HaiChun Liu, Qiang Hu, LingYun Zeng, YingYing Tang, ZhengHui Yi, ChunBo Li, JiJun Wang, TianHong Zhang   +13 more
doaj   +1 more source

Aberrant functional connectivity between the amygdala and the temporal pole in drug-free generalized anxiety disorder

Frontiers in Human Neuroscience, 2016
The amygdala and the dorsolateral prefrontal cortex (DLPFC) play important roles in emotion dysregulation, which has a profound impact on etiologic research of generalized anxiety disorder (GAD).
Wei Li, Huiru Cui, Zhipei Zhu, Li Kong, Qian Guo, Yikang Zhu, Qiang Hu, Lanlan Zhang, Hui Li, Qingwei Li, Jiangling Jiang, Jordan Meyers, Jianqi Li, Jijun Wang, Jijun Wang, Jijun Wang, Zhi Yang, Chunbo Li, Chunbo Li, Chunbo Li   +19 more
doaj   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Near-Infrared Stimulation in Psychiatry Disorders: A Systematic Review of Efficacy and Biological Mechanisms

NeuroSci
Background: Photobiomodulation (PBM), also referred to as low-level light therapy (LLLT), is an emerging non-pharmacological approach. This treatment is considered low-risk, cost-effective, and non-invasive, utilizing near-infrared light (NIR).
Joanna Woźniak, Michał Pazdrak, Ada Domanasiewicz, Jakub Kaźmierski   +3 more
doaj   +1 more source

Relationships among nitrous oxide exposure, neurological injury and biomarkers

British Journal of Clinical Pharmacology, EarlyView.
Aims Recreational nitrous oxide (N2O) misuse is an increasing public health problem associated with functional cobalamin (B12) deficiency and severe neurological complications. Despite growing recognition of its harms, the dose–response relationship and clinical value of biomarkers remain unclear.
Laxna Bhujel, Angela L. Chiew, Bhashita Jagarlamudi, Pramod Chandru, Naren Gunja, Nancy Briggs, Betty S. Chan   +6 more
wiley   +1 more source

A case report of dissociative conversion disorder primarily manifesting as intermittent fainting accompanied by myoclonic seizures

Shanghai Jiaotong Daxue xuebao. Yixue ban
The characteristic features of dissociative conversion disorder entail a partial or complete loss of normal integration in memory, identity awareness, immediate sensation, and motor control.
TANG Peiyuan, WANG Chongze, HONG Wu, FEI Hui, YI Zhenghui, LÜ Qinyu   +5 more
doaj   +1 more source

Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Molecular Brain, 2017
Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory.
Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He, Ying Zhou, Weidong Li   +17 more
doaj   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Differential effects of cognitive training and aerobic exercise on regional gray matter volume and inter-regional covariance in community-dwelling older adults

Scientific Reports
Previous studies have shown that both cognitive training and aerobic exercise benefit cognition and brain structure in healthy older adults, yet direct comparisons are limited. This study aimed to compare the effects of three months of cognitive training
Lijuan Jiang, Xinyi Cao, Ting Li, Kai Wei, Shaohui Lin, Junjie Yang, Nannan Gu, Yang Hu, Chunbo Li   +8 more
doaj   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source