Results 131 to 140 of about 3,094,120 (388)

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi   +7 more
wiley   +1 more source

Transcriptome analysis to explore the mechanism of downregulated TNIK influencing the effect of risperidone

open access: yesFrontiers in Pharmacology
BackgroundRisperidone is one of the most reliable and effective antipsychotics for schizophrenia treatment. However, the mechanism of action of risperidone is not yet fully understood.
Ruixue Yuan   +8 more
doaj   +1 more source

Social and spatial heterogeneity in psychosis proneness in a multilevel case-prodrome-control study [PDF]

open access: yes, 2014
To test whether spatial and social neighbourhood patterning of people at ultra-high risk (UHR) of psychosis differs from first-episode psychosis (FEP) participants or controls and to determine whether exposure to different social environments is evident ...
Aguilar, E   +10 more
core   +1 more source

Is Schizophrenia a Scapegoat? the Role of Childhood Traumas and Theory of Mind on Crime

open access: yesCriminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background Childhood traumas and low theory of mind abilities have been shown to be associated with violence, crime and schizophrenia. Understanding the factors that predispose to violent behaviour by patients with schizophrenia is important for treatment and safety.
Cetin Sahabettin   +3 more
wiley   +1 more source

Delayed Neuropsychiatric Syndrome Due to Unrecognized Carbon Monoxide Toxicity: A Case Report

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Carbon monoxide (CO) is a leading cause of poison‐related deaths in children and frequently results in nonspecific neurological symptoms and imaging findings. Rarely, pediatric patients develop a delayed neuropsychiatric syndrome (DNS) following a lucid interval.
Alexandria Valdrighi   +3 more
wiley   +1 more source

Synthesis of New N,N′‐Diarylureas and Their Theoretical Study as Cannabinoid‐1 Receptor Inhibitors

open access: yesChemPlusChem, EarlyView.
A series of new pyrazolo‐ and triazolo‐based N,N′‐diarylureas is synthesized following the triphosgene protocol in the last step. Density functional theory calculations and molecular docking provide strong evidence that all new compounds bind strongly to the cannabinoid‐1 (CB‐1) receptor, showing comparable results with the known allosteric CB‐1 ...
Eirini Tsemperlidou   +4 more
wiley   +1 more source

A continuum of psychosis, one human gene, and not much else - the case for homogeneity [PDF]

open access: yes, 1995
The contention of this paper is that psychoses are not a collection of separate and unrelated diseases, but a set of diverse expressions of a single underlying entity.
Crow, Prof TJ
core   +1 more source

Potential Benefits of Incorporating Peer-to-Peer Interactions Into Digital Interventions for Psychotic Disorders: A Systematic Review.

open access: yesPsychiatric Services, 2017
OBJECTIVE Peer-to-peer interactions and support groups mitigate experiences of social isolation and loneliness often reported by individuals with psychotic disorders.
B. Biagianti   +2 more
semanticscholar   +1 more source

Self‐Disgust, Body‐Related Attentional Bias and Body Dissatisfaction: A Virtual Reality and Eye‐Tracking Exploration

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examines the relationships between self‐disgust, body dissatisfaction (BD), and attentional biases (AB) toward weight‐related body areas, exploring whether self‐disgust predicts attentional avoidance and moderates the relationship between BD and AB.
Mariarca Ascione   +6 more
wiley   +1 more source

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