Results 61 to 70 of about 50,737 (331)
eLifeMemory impairment in chronic pain patients is substantial and common, and few therapeutic strategies are available. Chronic pain-related memory impairment has susceptible and unsusceptible features.
Mengqiao Cui +14 more
doaj +1 more source
New method for the study of psychotropic drug effects under simulated clinical conditions [PDF]
arXiv, 2007 The sensory contact model allows forming different psychopathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, hypersensitivity, cognition disturbances, anhedonia, alcoholism etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as
arxiv
Graph Distance Neural Networks for Predicting Multiple Drug Interactions [PDF]
arXiv, 2022 Since multidrug combination is widely applied, the accurate prediction of drug-drug interaction (DDI) is becoming more and more critical. In our method, we use graph to represent drug-drug interaction: nodes represent drug; edges represent drug-drug interactions.
arxiv
In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes
Chemistry – A European Journal, Accepted Article.Advanced clinical trials investigate the Psilocybe magic mushroom natural product psilocybin as a treatment against major depressive disorder. Currently, synthetic material is used to meet the demand for legitimate pharmaceutical purposes. Here, we report an in vitro approach to biocatalytically produce psilocybin on a solid‐phase matrix charged with ...
Tim Schäfer +7 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 449-456, December 2022., 2022 Abstract Aim It is controversial whether psychotic features are a risk factor for relapse in patients with electroconvulsive therapy‐responsive major depressive disorder. A recent study reported that benzodiazepine receptor agonists reduce relapse of psychotic depression.
Akise Umakoshi +7 more
wiley +1 more source
Neurobiology of Stress, 2022 Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji +6 more
doaj
Drug-target affinity prediction method based on consistent expression of heterogeneous data [PDF]
arXiv, 2022 The first step in drug discovery is finding drug molecule moieties with medicinal activity against specific targets. Therefore, it is crucial to investigate the interaction between drug-target proteins and small chemical molecules. However, traditional experimental methods for discovering potential small drug molecules are labor-intensive and time ...
arxiv
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 410-420, December 2022., 2022 Three studies comparing quetiapine with lithium were identified and analyzed; no other antipsychotic‐mood stabilizer combinations were found. Although this study found no differences in the efficacy and safety of quetiapine and lithium for bipolar depression, a comprehensive comparison of antipsychotics and mood stabilizers was not performed.
Masaya Ogasawara +8 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio +6 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022 Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley +1 more source