Results 61 to 70 of about 100,051 (354)

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

STAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng Xiao   +4 more
doaj  

Challenges and pitfalls of antipsychotic prescribing in people with learning disability [PDF]

, 2017
No abstract ...
Alexander, Regi T., Bhaumik, Sabyasachi, Cooper, Sally A., Hastings, Richard, Kapugama, Chaya L., Roy, Ashok, Shankar, Rohit, Tromans, Samuel J.   +7 more
core   +1 more source

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D4R) Antagonist in vitro Tool compounds

ChemMedChem, EarlyView.
The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi, Sumaiya Nahid, Anish K. Vadukoot, Corey R. Hopkins   +3 more
wiley   +1 more source

Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain–CSF circuit

Frontiers in Neuroscience
IntroductionTo elucidate the cellular composition of the cerebrospinal fluid-contacting nucleus, establish a comprehensive gene expression database for this nucleus, and investigate its potential functional roles.Methodswe used single-cell sequencing ...
Ying Li, Ying Li, Ying Li, Bin Gui, Bin Gui, Bin Gui, Yijun Zhang, Yijun Zhang, Yijun Zhang, Licai Zhang, Licai Zhang, Licai Zhang   +11 more
doaj   +1 more source

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Neurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang   +6 more
doaj  

How did the use of psychotropic drugs change during the Great Recession in Portugal? A follow-up to the National Mental Health Survey

BMC Psychiatry, 2020
Background Research suggests that economic recessions might be associated with a higher use of psychotropic drugs, but literature is scarce and contradictory in identifying the most vulnerable groups. This study aims to assess possible changes in the use
Manuela Silva, Ana Antunes, Sofia Azeredo-Lopes, Graça Cardoso, Miguel Xavier, Benedetto Saraceno, José Miguel Caldas-de-Almeida   +6 more
doaj   +1 more source

Bridging THC Knowledge Gaps for Safer Roads: A Call for Action

Clinical Pharmacology &Therapeutics, EarlyView.
The rising cases of cannabis‐impaired driving present a looming public safety concern that's currently addressed through varying state regulations. However, these regulations are yet validated and lack scientific robustness. One of the roadblocking factors is our insufficient understanding of THC's pharmacokinetics (PK) and pharmacodynamics (PD) due to
Peizhi Li, Guohua An
wiley   +1 more source

Стан злочинності, пов’язаної із незаконним обігом наркотичних засобів, психотропних речовин і прекурсорів [PDF]

, 2016
У статті розглянуто загальний стан злочинності, пов’язаної із незаконним обігом наркотичних засобів, психотропних речовин і прекурсорів на теренах України та в окремих регіонах, виявлено загальні небезпечні тенденції поширення окремих видів наркотичних ...
Косміна, Н. М., Кричковська, Лідія Василівна, Петров, Сергій Олександрович, Петрова, Ірина Анатоліївна   +3 more
core   +1 more source

Antipsychotic Drug Use: Managing Cardiometabolic and Cost Effects [PDF]

, 2018
Across the US, 30%, or approximately one third of people meet the criteria for at least one mental illness.1 Of those with severe mental illness (SMI), namely schizophrenia and bipolar disorder, the mortality rate is more than twofold compared to the ...
Braga, Olivia G
core   +1 more source

A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) [PDF]

, 2016
<p>A 30-year old man was found dead in his home after inhaling fumes of a powder burned on aluminum foil. Blood and urine were taken by the medical examiner during the external body examination and submitted to the laboratory for a comprehensive ...
Blanckaert, Peter, Coopman, Vera, Cordonnier, Jan, Van Calenbergh, Serge, Van Parys, Geert   +4 more
core   +2 more sources