Results 41 to 50 of about 42,511 (262)

Gut microbes–spinal connection is required for itch sensation

Gut Microbes
The gut microbiota has been linked to a number of neurological disorders. However, it is unclear whether the gut microbiota is involved in the genesis of chronic itch, a refractory condition that afflicts patients both physically and mentally.
Tong Jin, Si-Yuan Li, Hong-Li Zheng, Xiao-Dan Liu, Yue Huang, Gan Ma, Ya-Xuan Zhao, Xiao-Tian Zhao, Li Yang, Qi-Hui Wang, Hong-Jun Wang, Chengyong Gu, Zhiqiang Pan, Fuqing Lin   +13 more
doaj   +1 more source

Distribution of Psychotropic Drugs Into Lipoproteins [PDF]

Therapeutic Drug Monitoring, 2019
Aim: The aim of this pilot study was to investigate whether psychotropic drugs frequently analyzed in a routine therapeutic drug monitoring laboratory bind to low-density lipoproteins/very-low-density lipoproteins (LDL/VLDL) in human serum.
Serkland, Trond T., Schjøtt, Jan, Berg, Jon Andsnes, Herfindal, Lars, Riedel, Bettina, Skrede, Silje   +5 more
openaire   +4 more sources

Genome‐Wide Association Study of Symptom Change Following Cognitive Behavioral Therapy for Common Mental Disorders

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Cognitive behavioral therapy (CBT) is a well‐established, evidence‐based treatment for common mental disorders such as depression, anxiety disorders, and obsessive‐compulsive disorder (OCD). However, treatment outcomes vary widely, and a substantial proportion of patients do not achieve sufficient improvement.
Julia Bäckman, Olly Kravchenko, Matthew Halvorsen, Elles de Schipper, Ekaterina Ivanova, Viktor Kaldo, Nils Hentati Isacsson, Thorstein Olsen Eide, Kira D. Höffler, Manuel Mattheisen, Bjarne Hansen, Gerd Kvale, Kristen Hagen, Jan Haavik, David Mataix‐Cols, James J. Crowley, John Wallert, Christian Rück, Nordic OCD and Related Disorders Consortium (NORDiC), Julia Bäckman, Long‐Long Chen, James J. Crowley, Elles de Schipper, Diana Pascal, Jan Haavik, Kristen Hagen, Matthew W. Halvorsen, Bjarne Hansen, Kira D. Höffler, Fredrik Johansson, Anna K. Kähler, Elinor K. Karlsson, Gerd Kvale, Paul Lichtenstein, Kerstin Lindblad‐Toh, Manuel Mattheisen, David Mataix‐Cols, Kathleen Morrill, Christian Rück, Thorstein Olsen Eide, Nora I. Strom, John Wallert   +41 more
wiley   +1 more source

Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models

Pharmacological Research
Aberrant energy metabolism in the brain is a common pathological feature in the preclinical Alzheimer's Disease (AD). Recent studies have reported the early elevations of glycolysis-involved enzymes in AD brain and cerebrospinal fluid according to a ...
Xiu Yang, Yuan-Hao Chen, Le Liu, Zheng Gu, Yue You, Jing-Ru Hao, Nan Sun, Can Gao   +7 more
doaj   +1 more source

Nontobacco Nicotine Dependence Is Associated With Perioperative Complications and Repeat Surgery After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino, Alexander N. Berk, Logan M. Good, Jeremy M. Adelstein, Robert J. Wetzel, George Ochenjele, Joshua K. Napora   +6 more
wiley   +1 more source

RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease

Acta Neuropathologica Communications
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder among the elderly, with limited effective treatments available in clinical practice.
Miao-Jin Ji, Yun Li, Jiao Yang, Kangjunjie Wang, Shuning Sang, Hong Yang, Chenhao Tian, Xin Tang, Ji-Heng Cai, Tianhan He, Cheng Zhang, Huanyao Tang, Tiantao Cui, Xinran Meng, Xiang Cao, Jiaqi Zhu, Jie Wang, Jun-Li Cao, Daming Gao, Chao Liu   +19 more
doaj   +1 more source

The Effectiveness of Acceptance and Commitment Therapy Group Intervention (Navigator ACT) for Parents of Children With Neurodevelopmental Disabilities: A Randomized Controlled Trial

Autism Research, EarlyView.
ABSTRACT High levels of parental stress and psychological inflexibility are common among caregivers raising children with neurodevelopmental disabilities. Navigator ACT is a group‐based treatment developed to increase psychological flexibility and reduce the impact of stress among parents of children with various disabilities (e.g., autism spectrum ...
T. Holmberg Bergman, P. Lappalainen, A. Ghaderi, T. Hirvikoski   +3 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Cell types and neuronal genetic architecture in the rat CSF-contacting nucleus and the role of 5-HT in this nucleus in mediating morphine addiction through the brain–CSF circuit

Frontiers in Neuroscience
IntroductionTo elucidate the cellular composition of the cerebrospinal fluid-contacting nucleus, establish a comprehensive gene expression database for this nucleus, and investigate its potential functional roles.Methodswe used single-cell sequencing ...
Ying Li, Ying Li, Ying Li, Bin Gui, Bin Gui, Bin Gui, Yijun Zhang, Yijun Zhang, Yijun Zhang, Licai Zhang, Licai Zhang, Licai Zhang   +11 more
doaj   +1 more source