Results 21 to 30 of about 100,757 (302)

Post-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases

Frontiers in Pharmacology, 2022
Cav1.2 plays an essential role in learning and memory, drug addiction, and neuronal development. Intracellular calcium homeostasis is disrupted in neurodegenerative diseases because of abnormal Cav1.2 channel activity and modification of downstream Ca2 ...
Yun Li, Hong Yang, Tianhan He, Liang Zhang, Chao Liu   +4 more
doaj   +1 more source

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa, Gallagher, Cathal, Isse, Libin, Mann, Sanpreet   +3 more
core   +2 more sources

Unintentional drowning : Role of medicinal drugs and alcohol [PDF]

, 2017
Background: Alcohol is a well-known risk factor in unintentional drownings. Whereas psychotropic drugs, like alcohol, may cause psychomotor impairment and affect cognition, no detailed studies have focused on their association with drowning.
Lillsunde, Pirjo, Lunetta, Philippe, Pajunen, Tuulia, Smith, Gordon, Vincenzi, Frank F., Vuori, Erkki   +5 more
core   +2 more sources

The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice

Frontiers in Molecular Neuroscience, 2022
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu, Ye Liu, Ye Liu, Fang-Fang Zhang, Fang-Fang Zhang, Fang-Fang Zhang, Ying Song, Ying Song, Ying Song, Ran Wang, Ran Wang, Qi Zhang, Qi Zhang, Qi Zhang, Zhong-Shan Shen, Zhong-Shan Shen, Zhong-Shan Shen, Fei-Fei Zhang, Fei-Fei Zhang, Fei-Fei Zhang, Dan-Ya Zhong, Dan-Ya Zhong, Dan-Ya Zhong, Xiao-Hui Wang, Xiao-Hui Wang, Xiao-Hui Wang, Qing Guo, Qing Guo, Qing Guo, Qiong-Yao Tang, Qiong-Yao Tang, Qiong-Yao Tang, Zhe Zhang, Zhe Zhang, Zhe Zhang   +34 more
doaj   +1 more source

Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle

Frontiers in Neuroscience, 2021
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle.
Weinan Zhao, Weinan Zhao, Weinan Zhao, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Qing Li, Yu Ma, Yu Ma, Yu Ma, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Bingqian Fan, Bingqian Fan, Bingqian Fan, Xiaojing Zhai, Xiaojing Zhai, Xiaojing Zhai, Mengfan Hu, Mengfan Hu, Mengfan Hu, Mengfan Hu, Qing Wang, Qing Wang, Qing Wang, Qing Wang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Moruo Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Yixue Qin, Yixue Qin, Yixue Qin, Yixue Qin, Sha Sha, Sha Sha, Sha Sha, Sha Sha, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Zhonghao Gan, Fan Ye, Yihan Xia, Guangchao Zhang, Guangchao Zhang, Guangchao Zhang, Li Yang, Li Yang, Li Yang, Shiya Zou, Shiya Zou, Shiya Zou, Zheng Xu, Zheng Xu, Zheng Xu, Sunhui Xia, Sunhui Xia, Sunhui Xia, Yumei Yu, Yumei Yu, Yumei Yu, Mannan Abdul, Mannan Abdul, Mannan Abdul, Mannan Abdul, Jun-Xia Yang, Jun-Xia Yang, Jun-Xia Yang, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Jun-Li Cao, Fang Zhou, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang   +83 more
doaj   +1 more source

The PrLGlu→avBNSTGABA circuit rapidly modulates depression-like behaviors in male mice

iScience, 2023
Summary: Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests ...
Jie-ying Chen, Ke Wu, Miao-miao Guo, Wei Song, Si-ting Huang, Yong-mei Zhang   +5 more
doaj   +1 more source

Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study [PDF]

, 2012
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer ...
A J Lee, C Bond, C Burton, C Burton, DR Cox, E Martin-Merino, F Desplenter, F Hansen, G Laekeman, G Rait, J Madden, JC Holland, JL Roffman, K Lefevre, KC Yung, L Hodges, M Miovic, M Sharpe, M Vahdaninia, M Watson, MB First, MJ Massie, NF Khan, P Lockhart, P Murchie, PP Roy-Byrne, R Morris, R Munoz-Arroyo, RA Lewis, S Simoens, S Wein, SB Patten, TL Deshields, V Strong   +33 more
core   +1 more source

Initiation of Psychotropic Medication after Partner Bereavement: A Matched Cohort Study [PDF]

, 2013
Background Recent changes to diagnostic criteria for depression in DSM-5 remove the bereavement exclusion, allowing earlier diagnosis following bereavement.
A Bourke, AL Forte, Christina R. Victor, Derek G. Cook, DM Fick, DS Davydow, E Bui, EL Fosbøl, G Brown, Iain M. Carey, J Glass, J Möller, J Warner, James Coyne, JC Wakefield, JD Lewis, JM Cook, M Stroebe, ME Charlson, R Mojtabai, S Zisook, S Zisook, SM Shah, SM Shah, SM Shah, Stephen DeWilde, Sunil M. Shah, Tess Harris   +27 more
core   +3 more sources

Current Concepts on Drug Abuse and Dependence [PDF]

, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza, Bălălău, Cristian, Ciobanu, Anne-Marie, Cobani, Oana Denisa, Negrei, Carolina, Vlăsceanu, Ana Maria   +5 more
core   +7 more sources

Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp technique

STAR Protocols, 2023
Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng Xiao   +4 more
doaj   +1 more source