Results 31 to 40 of about 1,082,361 (305)

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Cell Death and Disease
Neuroinflammation is a key factor in the pathogenesis of Parkinson’s disease (PD). Activated microglia in the central nervous system (CNS) and infiltration of peripheral immune cells contribute to dopaminergic neuron loss. However, the role of peripheral
Wei Song, Zi-ming Zhou, Le-le Zhang, Hai-feng Shu, Jin-ru Xia, Xia Qin, Rong Hua, Yong-mei Zhang   +7 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Knowledge and Perception Towards Psychotropic Drugs Among the General Population in Saudi Arabia. [PDF]

Psychol Res Behav Manag
Eatedal M Al-Shareef,1 Alaa M Kadah Salim,1 Nada M Al-Farrah,1 Bader M Al-Murad,1 Adnan A Moallem,1 Mohammed A Radwan,1 Salman Hakami,2 Asim M Alshanberi,1,3 Mohammed Shaikhomer,4 Safaa M Alsanosi5 1General Medicine Program, Batterjee Medical College ...
Al-Shareef EM, Kadah Salim AM, Al-Farrah NM, Al-Murad BM, Moallem AA, Radwan MA, Hakami S, Alshanberi AM, Shaikhomer M, Alsanosi SM.   +9 more
europepmc   +2 more sources

TREM-1-dependent macrophage infiltration mediates visceral hypersensitivity via vlPAG GABAergic neuron activation in a mouse model of inflammatory bowel disease

Cellular & Molecular Biology Letters
Background Visceral pain is a common symptom of inflammatory bowel disease (IBD). Although triggering receptor expressed on myeloid cells-1 (TREM-1) has been shown to induce infiltration of peripheral immune cells into the central nervous system, the ...
Zi-ming Zhou, Wei Song, Miao-miao Guo, Yuan-qing Chu, Lu-bin Wang, Peng Cheng, Jing-wen Huang, Ting Su, Xu-Feng Huang, Yong-mei Zhang   +9 more
doaj   +1 more source

Prescribers´ of psychotropic drugs experiences and reflections on use and misuse of alcohol and psychotropic drugs among older people: A qualitative study [PDF]

, 2015
Background: Studies published the past ten years revealed that use and misuse of alcohol and psychotropic drugs is an increasing phenomenon among older people (aged 65 years and above).
Engedal, Knut, Johannessen, Aud, Helvik, Anne-Sofie, Sørlie, Venke, Ulstein, Ingun   +4 more
core   +1 more source

Dreams, Sleep, and Psychotropic Drugs

, 2020
International audienceOver the past 60 years, the impact of psychotropic drugs on dream recall and content has been scarcely explored. A review of the few existing experimental results on the topic leads us to the following conclusions.
Ruby, Perrine, M, Nicolas, Alain
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction

Cellular & Molecular Biology Letters
Background Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu, Chen Chen, Jia-Tao Lin, Xin-Hao Jiao, Wei Dong, Jie Wan, Qiang Liu, Yong-Kang Qiu, Ao Sun, Yi-Qi Liu, Chun-Hui Jin, He Huang, Hui Zheng, Cheng-Hua Zhou, Yu-Qing Wu   +14 more
doaj   +1 more source

The activation of GABAergic neurons in the hypothalamic tuberomammillary nucleus attenuates sevoflurane and propofol-induced anesthesia in mice

Frontiers in Pharmacology, 2023
Background: The histaminergic neurons in the hypothalamic tuberomammillary nucleus (TMN) have been suggested to play a vital role in maintaining a rising state.
Jing Liu, Jing Liu, Jing Liu, Jing Liu, Xiao Liu, Xiao Liu, Xiao Liu, Wen-Yu Zhou, Wen-Yu Zhou, Wen-Yu Zhou, Jun Gan, Jun Gan, Jun Gan, Jie Wang, Jie Wang, Jie Wang, Qi Zhang, Qi Zhang, Qi Zhang, Jun-Liang Li, Jun-Liang Li, Jun-Liang Li, Zhong-Shan Shen, Zhong-Shan Shen, Zhong-Shan Shen, Yue-Ying Zhang, Qiong-Yao Tang, Qiong-Yao Tang, Qiong-Yao Tang, Zhe Zhang, Zhe Zhang, Zhe Zhang   +31 more
doaj   +1 more source